Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$134K - $201K *

Engage with key biopharma accounts to drive growth and enhance relationships. You will craft strategic account plans, navigate negotiations, and ensure customer satisfaction while leveraging our advan...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $137K *

Unlock potential by leading strategic client relationships to drive revenue growth and retention. This high-impact role requires expertise in digital media and AI tools, fostering executive partnershi...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Technical Services

$100K - $120K *

Elevate patient care by assessing and managing medication therapy in a collaborative environment. Contribute to a dedicated pharmacy team, ensuring optimal drug use and safety while supervising suppor...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$150K - $188K *

Accelerate progress at achieving sales goals in oncology by driving product demand and executing launch plans. Collaborate with healthcare providers and internal teams to enhance patient care and ensu...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $169K *

Drive impactful demand generation strategies for the Public Sector, collaborating cross-functionally to execute integrated marketing campaigns that enhance pipeline growth and revenue. Leverage data-d...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Transform the corporate internal audit landscape by shaping product strategy and developing AI-driven solutions that enhance efficiency and quality throughout the audit lifecycle, while collaborating...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$107K - $199K *

Architect strategic initiatives to enhance operational efficiency through collaboration, process improvement, and organizational change management. Lead large-scale projects impacting diverse stakehol...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$107K - $199K *

Elevate your career by leading strategic initiatives that enhance operational efficiency. Collaborate across functions to drive impactful change, optimize processes, and mentor associates while delive...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$175K - $250K *

Lead the architectural strategy for Operational Technology, ensuring integration with enterprise objectives. Strategically influence technical decisions and guide multi-disciplinary teams in deliverin...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$136K - $220K *

Unlock project management excellence in Global Regulatory Affairs, driving timelines and compliance for drug submissions. Collaborate cross-functionally to ensure accurate documentation and effective...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$72K - $108K *

Unlock potential by developing strategic sales plans and fostering relationships to achieve quarterly goals. Drive impactful presentations and enhance product awareness while ensuring compliance with...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$177K - $221K *

Lead the charge in optimizing pricing contract operations, ensuring compliance and strategic insights for government and provider contracts. Collaborate cross-functionally to enhance business outcomes...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Drive strategic partnerships and revenue growth by fostering relationships with partners and sales teams. Lead joint marketing initiatives and advocate for partner success to enhance collaboration and...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Transform the future of businesses by leading operational strategies, enhancing efficiency, and driving growth. Collaborate with executive teams to create value, monitor performance, and ensure resour...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$94K - $148K *

Transform membership data quality by leading a team of analysts to enhance processes, ensure accuracy, and align with pharma partners. Drive performance metrics and implement improvements to meet evol...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$280K - $310K *

Join a dynamic team as you drive new business growth through consultative sales. Leverage your technical expertise to nurture relationships and close deals, while managing forecasts and customer data...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$88K - $110K *

Join a team that's dedicated to enhancing healthcare professional engagements through effective coordination and support. This role involves managing peer-to-peer education programs and ensuring compl...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Champion women's health by providing expert midwifery care in a collaborative, supportive environment. Enjoy a balanced work-life with a four-day week and mentorship opportunities while delivering at...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$107K - $178K *

Champion compliance excellence by ensuring adherence to NERC standards, guiding operational risk management, and supporting audit preparations. Collaborate with teams to enhance compliance programs an...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$122K - $292K *

Empower your career by leading advanced analytics to transform data into actionable insights. Collaborate with cross-functional teams to drive strategic decisions and enhance brand and consumer initia...

Yesterday

  •   8 - 10 years exp.  •   Business Services

$80K - $120K *

Contribute to customer success by developing technical expertise across platforms, integrations, and operational processes. Collaborate with teams to resolve issues and enhance solutions, while gainin...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Join a dynamic team to design and optimize data pipelines, ensuring quality and security for analytics and AI capabilities. Collaborate with cross-functional teams to deliver innovative data solutions...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Engage in comprehensive program management for data center operations, ensuring seamless transitions from construction to live operations. Shape maintainability, drive incident improvements, and enhan...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$149K - $166K *

Lead the charge in advancing cutting-edge mechanical engineering solutions for high-performance electronics in space systems. Collaborate with cross-functional teams to deliver innovative designs that...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$95K - $115K *

Transform patient care by delivering advanced palliative services in home settings. Collaborate with an interdisciplinary team to enhance quality of life for patients facing complex medical challenges...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.