Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Staff Data Scientist - Ads Marketplace
$190K - $283K *
Drive impactful data analyses and innovative experiment design to enhance product strategies and optimize Ads Marketplace performance, collaborating with cross-functional teams in a flexible, hybrid w...
Reposted yesterday
Finance Manager, Adaptive Planning
$110K - $130K *
Lead the charge in optimizing our Adaptive Planning platform, ensuring accurate data management and seamless integrations. Collaborate with cross-functional teams to enhance reporting and streamline f...
Yesterday
Senior Account Manager, Paid Media (Omnichannel)
$75K - $95K *
Elevate mobile app acquisition strategies by managing omni-channel paid media campaigns. Collaborate with clients to optimize performance, drive growth, and ensure seamless execution across platforms...
Yesterday
$90K - $92K *
Join a dynamic team as you support project execution and management for USACE maintenance tasks. Collaborate with stakeholders, track performance metrics, and guide project teams to ensure successful...
Yesterday
Vice President, Deputy General Counsel, Product, Regulatory & Litigation
$370K - $415K *
Unlock potential by leading Affirm's global legal strategy across Product, Regulatory, and Litigation teams. Collaborate with executives to drive innovation while managing complex legal risks in the c...
Yesterday
$83K - $140K *
Innovate financial strategies by partnering with R&D leaders to optimize costs, enhance reporting frameworks, and drive accurate forecasting in a dynamic environment. Your analytical skills will shape...
Yesterday
Senior Medical Science Liaison - Bone Health - MO, AR, KS
$172K - $233K *
Engage with healthcare leaders to advance scientific communication in bone health. This role involves collaboration, mentorship, and strategic support to enhance patient care and drive research initia...
Yesterday
$95K - $115K *
Shape the future of our organic social media presence by managing channels, coordinating campaigns, and leveraging analytics to enhance engagement and community growth across multiple platforms...
Yesterday
$85K - $118K *
Empower patient care by delivering dialysis treatments and collaborating with a dedicated team. Utilize your critical thinking skills in a fast-paced environment to ensure the safety and wellbeing of...
Yesterday
Altium Designer Trainer and Content Creator
$118K - $141K *
Deliver engaging training and develop content for Altium Designer, leveraging your PCB design expertise. Collaborate with teams to enhance training quality and support customer adoption through effect...
Yesterday
Senior Software Engineer, Operations Tools & Al Enablement
$120K - $145K *
Join a dynamic team to enhance Robotics Operations through innovative software solutions. Collaborate with cross-functional teams to identify needs, deliver impactful improvements, and maintain reliab...
Yesterday
$125K - $145K *
Lead and optimize transportation operations, driving excellence through team development, P&L management, and strategic partnerships. Foster a safety-first culture while exceeding customer expectation...
Yesterday
Commercial Project Manager, Pharmaceuticals
$80K - $95K *
Shape customer success by managing project timelines and expectations, fostering relationships, and ensuring accurate forecasting and billing. Drive operational excellence and continuous improvement t...
Reposted yesterday
$110K - $130K *
Champion employment law compliance and support HR initiatives in a dynamic startup. Collaborate with management and People Operations to address legal matters, streamline processes, and ensure best pr...
Yesterday
$74K - $93K *
Join a dedicated team as a Residential Nurse, providing compassionate care and support to residents in a transitional program. Collaborate with interdisciplinary teams to foster a safe and nurturing e...
Yesterday
$80K - $100K *
Engage customers by providing exceptional service and guidance in vehicle selection. Drive sales growth through relationship building and product knowledge while ensuring a positive dealership experie...
Yesterday
$65K - $181K *
Drive success by providing high-level executive support in a dynamic environment. Collaborate with cross-functional teams, manage complex schedules, and enhance organizational efficiency while maintai...
Yesterday
Director, Merchandising Operations
$145K - $180K *
Champion operational excellence by leading a dynamic team to enhance processes, drive complex projects, and ensure seamless collaboration across departments, all while improving patient outcomes in th...
Yesterday
Senior Proposal Strategist - Water (Kansas City, MO)
$95K - $115K *
Explore your career potential by leading proposal strategies that enhance competitive positioning. Collaborate with teams to develop compelling narratives and visuals, ensuring successful project subm...
Yesterday
Partnerships Operations Manager
$92K - $128K *
Transform partnership operations by managing billing, benefit administration, and cross-functional projects. Leverage your organizational skills to enhance member experiences and streamline processes...
Yesterday
$120K - $145K *
Join a team that's dedicated to enhancing client operations and driving revenue cycle success. Lead initiatives, foster relationships, and ensure performance excellence while collaborating with stakeh...
Yesterday
$250K - $289K *
Transform AI/ML engineering by leading innovative platform design and implementation, ensuring reliability and scalability to meet growing needs while collaborating across teams to drive business impa...
Reposted yesterday
Lead Consultant - Cybersecurity Commissioning, Verification & Validation
$110K - $130K *
Shape the future of cybersecurity by leading verification and validation efforts across industrial environments. Drive technical assessments, develop procedures, and ensure compliance with cybersecuri...
Yesterday
$110K - $130K *
Join us to take technical ownership of our global WordPress platform, enhancing performance and scalability. Collaborate with cross-functional teams to develop custom solutions and ensure a seamless u...
Reposted yesterday
$69K - $94K *
Manage procurement activities to ensure timely, cost-effective sourcing of goods and services. Collaborate with suppliers, optimize supply chain execution, and support contract negotiations to meet cu...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.