Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$190K - $283K *

Drive impactful data analyses and innovative experiment design to enhance product strategies and optimize Ads Marketplace performance, collaborating with cross-functional teams in a flexible, hybrid w...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Lead the charge in optimizing our Adaptive Planning platform, ensuring accurate data management and seamless integrations. Collaborate with cross-functional teams to enhance reporting and streamline f...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$75K - $95K *

Elevate mobile app acquisition strategies by managing omni-channel paid media campaigns. Collaborate with clients to optimize performance, drive growth, and ensure seamless execution across platforms...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Media

$90K - $92K *

Join a dynamic team as you support project execution and management for USACE maintenance tasks. Collaborate with stakeholders, track performance metrics, and guide project teams to ensure successful...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$370K - $415K *

Unlock potential by leading Affirm's global legal strategy across Product, Regulatory, and Litigation teams. Collaborate with executives to drive innovation while managing complex legal risks in the c...

United StatesRemote

Yesterday

  •   15+ years exp.  •   Finance & Insurance

$83K - $140K *

Innovate financial strategies by partnering with R&D leaders to optimize costs, enhance reporting frameworks, and drive accurate forecasting in a dynamic environment. Your analytical skills will shape...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$172K - $233K *

Engage with healthcare leaders to advance scientific communication in bone health. This role involves collaboration, mentorship, and strategic support to enhance patient care and drive research initia...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Shape the future of our organic social media presence by managing channels, coordinating campaigns, and leveraging analytics to enhance engagement and community growth across multiple platforms...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$85K - $118K *

Empower patient care by delivering dialysis treatments and collaborating with a dedicated team. Utilize your critical thinking skills in a fast-paced environment to ensure the safety and wellbeing of...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$118K - $141K *

Deliver engaging training and develop content for Altium Designer, leveraging your PCB design expertise. Collaborate with teams to enhance training quality and support customer adoption through effect...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Join a dynamic team to enhance Robotics Operations through innovative software solutions. Collaborate with cross-functional teams to identify needs, deliver impactful improvements, and maintain reliab...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Transportation

$125K - $145K *

Lead and optimize transportation operations, driving excellence through team development, P&L management, and strategic partnerships. Foster a safety-first culture while exceeding customer expectation...

Yesterday

  •   5 - 7 years exp.  •   Transportation

$80K - $95K *

Shape customer success by managing project timelines and expectations, fostering relationships, and ensuring accurate forecasting and billing. Drive operational excellence and continuous improvement t...

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion employment law compliance and support HR initiatives in a dynamic startup. Collaborate with management and People Operations to address legal matters, streamline processes, and ensure best pr...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Food & Beverages

$74K - $93K *

Join a dedicated team as a Residential Nurse, providing compassionate care and support to residents in a transitional program. Collaborate with interdisciplinary teams to foster a safe and nurturing e...

Yesterday

  •   Less than 5 years exp.  •   Staffing

$80K - $100K *

Engage customers by providing exceptional service and guidance in vehicle selection. Drive sales growth through relationship building and product knowledge while ensuring a positive dealership experie...

Yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$65K - $181K *

Drive success by providing high-level executive support in a dynamic environment. Collaborate with cross-functional teams, manage complex schedules, and enhance organizational efficiency while maintai...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$145K - $180K *

Champion operational excellence by leading a dynamic team to enhance processes, drive complex projects, and ensure seamless collaboration across departments, all while improving patient outcomes in th...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Explore your career potential by leading proposal strategies that enhance competitive positioning. Collaborate with teams to develop compelling narratives and visuals, ensuring successful project subm...

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$92K - $128K *

Transform partnership operations by managing billing, benefit administration, and cross-functional projects. Leverage your organizational skills to enhance member experiences and streamline processes...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Join a team that's dedicated to enhancing client operations and driving revenue cycle success. Lead initiatives, foster relationships, and ensure performance excellence while collaborating with stakeh...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$250K - $289K *

Transform AI/ML engineering by leading innovative platform design and implementation, ensuring reliability and scalability to meet growing needs while collaborating across teams to drive business impa...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Finance & Insurance

$110K - $130K *

Shape the future of cybersecurity by leading verification and validation efforts across industrial environments. Drive technical assessments, develop procedures, and ensure compliance with cybersecuri...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$110K - $130K *

Join us to take technical ownership of our global WordPress platform, enhancing performance and scalability. Collaborate with cross-functional teams to develop custom solutions and ensure a seamless u...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$69K - $94K *

Manage procurement activities to ensure timely, cost-effective sourcing of goods and services. Collaborate with suppliers, optimize supply chain execution, and support contract negotiations to meet cu...

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.