Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$77K - $202K *

Drive clinical operations modernization for healthcare providers, enhancing efficiency and service delivery. Analyze complex challenges, mentor junior staff, and foster client relationships while navi...

Yesterday

  •   Less than 5 years exp.  •   Legal & Accounting

$124K - $280K *

Drive clinical modernization initiatives in healthcare, leading multidisciplinary teams to enhance operations, technology workflows, and patient access while advising on transformation strategies and...

Yesterday

  •   8 - 10 years exp.  •   Legal & Accounting

$95K - $115K *

Drive regional compliance initiatives and operational readiness by leading enforcement strategies, coordinating multi-agency operations, and enhancing training programs to ensure safety in hazardous m...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Energy & Utilities

$150K - $180K *

Lead and innovate compliance strategies to ensure adherence to ERISA, DOL, and IRS regulations. Drive technology-enabled solutions, manage risk, and enhance operational excellence while coaching compl...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $180K *

Transform the future of cloud infrastructure by leading DevOps initiatives, enhancing systems integration, and driving innovative solutions for federal clients. Collaborate with stakeholders to optimi...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Shape the future of pet care by driving brand growth and innovation in a dynamic role. Manage day-to-day operations, collaborate cross-functionally, and execute strategic initiatives to enhance the Sm...

Yesterday

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$69K - $125K *

Drive strategic development by assessing opportunities and creating reports. Collaborate with cross-functional teams to enhance governance and achieve organizational goals in a dynamic, remote environ...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$92K - $110K *

Unlock potential by delivering advanced nursing care to oncology patients, coordinating comprehensive treatment plans, and enhancing clinical outcomes through collaboration and education in a supporti...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$75K - $180K *

Join a team that's shaping the future of marketing technology strategy. Drive enterprise-level initiatives across CDP, CRM, and analytics, translating business goals into actionable plans while collab...

Reposted yesterday

  •   5 - 7 years exp.  •   Media

$105K - $177K *

Join a dynamic team as a Senior Price-to-Win Analyst, leveraging your analytical skills to drive strategic pricing recommendations and enhance competitive positioning in high-stakes federal pursuits...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$150K - $230K *

Unlock potential by leading evidence generation strategies and methodologies. Drive scientific excellence and team development while collaborating across functions to address healthcare needs and enha...

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$79K - $115K *

Engage with high-growth tech companies as you drive sales cycles, build relationships, and close cloud contracts. This fast-paced role requires a hunter mentality and the ability to connect with both...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$155K - $170K *

Advance your career by leading compliance and risk initiatives in healthcare software. Drive SOC2 and HIPAA standards, engage with customers, and shape the future of compliance in a tech-forward envir...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$134K - $201K *

Engage with key biopharma accounts to drive growth and enhance relationships. You will craft strategic account plans, navigate negotiations, and ensure customer satisfaction while leveraging our advan...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $137K *

Unlock potential by leading strategic client relationships to drive revenue growth and retention. This high-impact role requires expertise in digital media and AI tools, fostering executive partnershi...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Technical Services

$100K - $120K *

Elevate patient care by assessing and managing medication therapy in a collaborative environment. Contribute to a dedicated pharmacy team, ensuring optimal drug use and safety while supervising suppor...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$150K - $188K *

Accelerate progress at achieving sales goals in oncology by driving product demand and executing launch plans. Collaborate with healthcare providers and internal teams to enhance patient care and ensu...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $169K *

Drive impactful demand generation strategies for the Public Sector, collaborating cross-functionally to execute integrated marketing campaigns that enhance pipeline growth and revenue. Leverage data-d...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Transform the corporate internal audit landscape by shaping product strategy and developing AI-driven solutions that enhance efficiency and quality throughout the audit lifecycle, while collaborating...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$107K - $199K *

Architect strategic initiatives to enhance operational efficiency through collaboration, process improvement, and organizational change management. Lead large-scale projects impacting diverse stakehol...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$107K - $199K *

Elevate your career by leading strategic initiatives that enhance operational efficiency. Collaborate across functions to drive impactful change, optimize processes, and mentor associates while delive...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$175K - $250K *

Lead the architectural strategy for Operational Technology, ensuring integration with enterprise objectives. Strategically influence technical decisions and guide multi-disciplinary teams in deliverin...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$136K - $220K *

Unlock project management excellence in Global Regulatory Affairs, driving timelines and compliance for drug submissions. Collaborate cross-functionally to ensure accurate documentation and effective...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$72K - $108K *

Unlock potential by developing strategic sales plans and fostering relationships to achieve quarterly goals. Drive impactful presentations and enhance product awareness while ensuring compliance with...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$177K - $221K *

Lead the charge in optimizing pricing contract operations, ensuring compliance and strategic insights for government and provider contracts. Collaborate cross-functionally to enhance business outcomes...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.