Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$85K - $105K *

Grow your career with us as you lead clinical care, develop RBTs, and partner with families to make a meaningful impact in the lives of children with autism. Join a supportive team focused on clinical...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$92K - $120K *

Join a team that's driving sales growth by engaging partners and employers in the employee benefits sector. This role focuses on developing relationships, presenting solutions, and achieving performan...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Drive revenue growth by selling mission-critical call handling solutions to public safety organizations. Build relationships, understand needs, and modernize 9-1-1 environments through consultative sa...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$175K - $210K *

Lead the North American high-tech sales strategy, driving revenue growth and team performance while building executive relationships and executing complex enterprise sales in a dynamic market...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Consumer Technology

$86K - $138K *

Empower cloud infrastructure management by optimizing AWS environments, automating tasks, and ensuring security compliance. Collaborate with cross-functional teams to enhance operational efficiency an...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$104K - $166K *

Shape the future of cybersecurity by leading vulnerability management initiatives, enhancing security posture, and driving remediation efforts across diverse environments. Collaborate with teams to en...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Aerospace & Defense

$104K - $166K *

Take ownership of cybersecurity initiatives by managing complex projects, ensuring compliance with federal regulations, and leading a team of experts to enhance incident response and information assur...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Aerospace & Defense

$146K - $234K *

Lead the charge in shaping federal IT programs by leveraging your DOJ or DEA experience. Collaborate with a team of experts to drive proposal development and manage complex projects in a dynamic envir...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Aerospace & Defense

$92K - $115K *

Drive successful client implementations by managing projects from inception to deployment. Collaborate cross-functionally to ensure timely, on-budget delivery while interfacing with stakeholders and v...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$142K - $177K *

Lead the charge in establishing strategic partnerships with pharmaceutical manufacturers, driving contract negotiations for rebates and discounts while enhancing client relationships and supporting fo...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Bring your expertise to a dynamic role as a Clinical Account Executive, where you'll lead specialty medication management, collaborate with healthcare professionals, and drive formulary development to...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$88K - $115K *

Empower organizational change by analyzing stakeholder needs and implementing effective strategies. Collaborate with leadership and teams to enhance processes, ensuring smooth transitions and measurab...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Business Services

$90K - $100K *

Unlock potential by managing and optimizing learning management systems for federal healthcare training. Collaborate with diverse teams to ensure effective course delivery, learner access, and accurat...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$102K - $111K *

Join a team that's dedicated to enhancing digital learning resources by managing SharePoint training sites, ensuring content accuracy, and supporting effective training experiences for federal healthc...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$31K - $130K *

Empower clients on their debt relief journey by providing compassionate consultations. Utilize your expertise to navigate sensitive conversations, ensuring clients regain financial confidence while ac...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$180K - $210K *

Lead a dynamic team to support shipyard operations, ensuring project success through strategic direction, effective communication, and performance management while fostering relationships and driving...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Business Services

$92K - $158K *

Drive innovative RFID solutions by leading design, customer engagement, and technical validation. Collaborate with teams to deliver reliable identification and tracking systems, ensuring alignment wit...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$122K - $211K *

Champion the development of a secure, user-centric application for managing mission data and digital assets, ensuring seamless integration and collaboration while leading a team of developers in a dyn...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$92K - $158K *

Empower cross-functional collaboration and operational efficiency in hardware development. Support project execution and coordination, ensuring alignment across teams while managing multiple prioritie...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$112K - $192K *

Join a dynamic team to develop and refine cost estimates for critical federal programs, ensuring effective budgetary decisions and enhancing national security through advanced technology solutions...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$140K - $200K *

Empower innovation by leading the design of secure, scalable Atlassian Cloud environments. This senior role involves architecture, migration strategy, and technical leadership to support modernization...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Champion complex LTC Professional Liability claims, managing them from inception to resolution. Collaborate with experts and leadership to shape strategies, ensuring effective outcomes in a high-stake...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$104K - $156K *

Lead the design, development, and integration of AI applications that enhance business operations. Collaborate with cross-functional teams to deliver technical solutions while maintaining security, re...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$89K - $109K *

Drive project accounting excellence by leading a team, ensuring accurate billing, and collaborating with project managers. Oversee financial reporting and client relations while mentoring junior staff...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$60K - $115K *

Transform your career by managing financial processes and compliance, analyzing project health, and training teams. Collaborate with stakeholders to ensure effective financial deliverables and reporti...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.