Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $115K *

Join a team that's dedicated to enhancing ERP solutions for colleges and universities. As a consultant, you'll collaborate on Ellucian Banner implementations, ensuring client needs are met within scop...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Lead the Production Support Operations team by ensuring reliable IT systems, managing cloud technologies, and driving continuous improvement while overseeing staff and coordinating with stakeholders f...

Yesterday

  •   5 - 7 years exp.  •   Transportation

$95K - $115K *

Transform your career by leading IT operations, ensuring system reliability, and driving continuous improvement. Oversee a dedicated team while managing cloud technologies and infrastructure to suppor...

Yesterday

  •   5 - 7 years exp.  •   Transportation

$110K - $130K *

Lead the charge in enhancing regulatory compliance across satellite operations, ensuring adherence to export controls, international trade laws, and corporate obligations while collaborating with cros...

Yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$124K - $271K *

Drive transformative AI implementations by collaborating cross-functionally to deploy production-ready agents within 90 days, enhancing product scalability and accelerating revenue growth through hand...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Information Technology

$73K - $182K *

Empower the future of AI learning by developing impactful technical content that enhances workforce skills. Collaborate with experts to create engaging courses and assessments, ensuring learners can a...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$180K - $200K *

Drive innovative marketing strategies to enhance access to healthcare products by collaborating with cross-functional teams and executing impactful initiatives that improve payer and provider engageme...

RemoteRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $200K *

Grow your career with a strategic leadership role driving sales growth, shaping market strategies, and leading cross-functional teams to enhance customer value and expand market share in a dynamic env...

RemoteRemote

Yesterday

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$90K - $140K *

Lead the charge in designing and implementing cutting-edge SASE solutions, enhancing networking and cloud security for distributed environments. Collaborate with cross-functional teams to advance secu...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Lead maintenance operations to ensure optimal equipment and facility performance. Oversee a skilled team, manage budgets, and ensure compliance with safety standards while enhancing operational effici...

Yesterday

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$200K - $210K *

Drive operational excellence by leading a diverse team to enhance maintenance strategies, ensuring quality control and financial performance across a large portfolio while fostering a safety-first cul...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$79K - $112K *

Transform client relationships by leading participant communications strategies for large and not-for-profit markets. Drive engagement through multi-channel campaigns, ensuring client satisfaction and...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$231K - $250K *

Transform your career by leading complex commercial transactions and providing strategic legal counsel. Collaborate with cross-functional teams to mitigate risks and enhance compliance while managing...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Business Services

$90K - $110K *

Build and support AI tools and workflows, collaborating with stakeholders to create scalable solutions that integrate with enterprise platforms, ensuring reliability and security throughout the soluti...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$190K - $237K *

Lead the charge in developing strategic portfolio initiatives for oncology, driving cross-functional collaboration to enhance late-stage clinical development and market positioning through actionable...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join a team that's driving growth by managing strategic accounts and expanding relationships. You'll execute long-term sales strategies, engage stakeholders, and lead negotiations to enhance our marke...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Finance & Insurance

$110K - $130K *

Empower your career by leading technical service management initiatives, enhancing processes, and fostering customer relationships. Drive operational excellence and governance while ensuring team prod...

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$89K - $118K *

Manage critical product documentation and engineering changes, ensuring accuracy and efficiency in BOM configurations. Collaborate across teams to support product development and timely launches in th...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$56K - $125K *

Lead the charge in managing store operations, enhancing customer experiences, and driving sales growth. Oversee team performance, inventory management, and compliance while fostering a positive work e...

Yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$56K - $125K *

Lead the charge in managing store operations, enhancing customer experiences, and driving sales growth through effective team leadership and strategic planning. Ensure compliance with regulations whil...

Yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$125K - $150K *

Join a team that's dedicated to transforming healthcare marketing. Lead cross-functional initiatives, provide strategic insights, and boost client success through innovative, data-driven campaigns in...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $220K *

Unlock potential by joining a dynamic security team to enhance cloud and application security, ensuring compliance and fostering a secure culture across all functions while leveraging cutting-edge tec...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$85K - $102K *

Optimize national licensing and bonding programs for public warehouses, ensuring compliance and operational efficiency. Lead policy development, manage stakeholder relations, and advise senior managem...

Yesterday

  •   Less than 5 years exp.  •   Food & Beverages

$119K - $186K *

Shape the future of CMC regulatory leadership by driving strategic initiatives, managing client projects, and mentoring teams to ensure excellence in delivery and business growth across complex health...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $140K *

Lead the charge in architecting and building intelligent systems for autonomous GRC workflows, leveraging C#/.NET and Blazor to create scalable, high-performance solutions that drive innovation and ef...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.