Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$90K - $110K *

Collaborate with cross-functional teams to manage the full contract lifecycle, ensuring compliance and risk mitigation while negotiating agreements that align with business objectives and protect comp...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Join a dynamic team as you drive revenue growth through virtual Finance & Insurance sales. Lead the full sales process, enhance customer experiences, and achieve performance targets in a fast-paced, r...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$108K - $130K *

Transform enterprise web application security by engineering and managing F5 WAF policies. Collaborate with cybersecurity teams to enhance protection, tune policies, and respond to incidents, ensuring...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Transform patient access to specialty medications by leading implementation projects, optimizing workflows, and collaborating with clinical teams to enhance pharmacy experiences and resolve issues eff...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$126K - $188K *

Unlock the potential of cybersecurity by leading risk management initiatives, enhancing security operations, and driving impactful projects. Collaborate globally to develop automation and metrics that...

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$106K - $284K *

Lead the charge in designing and delivering secure, scalable microservices that enhance healthcare data exchange. Collaborate with cross-functional teams to ensure compliance and operational excellenc...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Grow your career with a dynamic role overseeing construction projects, ensuring compliance with specifications and budgets. Lead inspections, manage contracts, and coordinate teams on diverse projects...

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$54K - $145K *

Unlock potential by collaborating with cross-functional teams to deliver impactful analysis and requirements for Medicare and Medicaid enrollment solutions within an Agile framework, ensuring seamless...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$183K - $200K *

Shape the future of offensive security by leading advanced penetration testing, red-team engagements, and AI-assisted workflows. Collaborate with cross-functional teams to enhance security measures an...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Consumer Technology

$80K - $95K *

Take ownership of external financial reporting by preparing and consolidating quarterly statements, ensuring GAAP compliance, and enhancing reporting initiatives. Collaborate with leadership to delive...

Yesterday

  •   Less than 5 years exp.  •   Transportation

$80K - $95K *

Transform building performance by conducting assessments and energy audits for diverse properties. Analyze systems, develop recommendations, and prepare reports to enhance efficiency and sustainabilit...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$145K - $175K *

Empower organizations to transform workflows with AI by architecting solutions that integrate Grok Build and Grok Bot. Collaborate with engineering teams and executives to drive adoption and optimize...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Join a team that's dedicated to enhancing ERP solutions for colleges and universities. As a consultant, you'll collaborate on Ellucian Banner implementations, ensuring client needs are met within scop...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Lead the Production Support Operations team by ensuring reliable IT systems, managing cloud technologies, and driving continuous improvement while overseeing staff and coordinating with stakeholders f...

Yesterday

  •   5 - 7 years exp.  •   Transportation

$95K - $115K *

Transform your career by leading IT operations, ensuring system reliability, and driving continuous improvement. Oversee a dedicated team while managing cloud technologies and infrastructure to suppor...

Yesterday

  •   5 - 7 years exp.  •   Transportation

$110K - $130K *

Lead the charge in enhancing regulatory compliance across satellite operations, ensuring adherence to export controls, international trade laws, and corporate obligations while collaborating with cros...

Yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$124K - $271K *

Drive transformative AI implementations by collaborating cross-functionally to deploy production-ready agents within 90 days, enhancing product scalability and accelerating revenue growth through hand...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Information Technology

$73K - $182K *

Empower the future of AI learning by developing impactful technical content that enhances workforce skills. Collaborate with experts to create engaging courses and assessments, ensuring learners can a...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$180K - $200K *

Drive innovative marketing strategies to enhance access to healthcare products by collaborating with cross-functional teams and executing impactful initiatives that improve payer and provider engageme...

RemoteRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $200K *

Grow your career with a strategic leadership role driving sales growth, shaping market strategies, and leading cross-functional teams to enhance customer value and expand market share in a dynamic env...

RemoteRemote

Yesterday

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$90K - $140K *

Lead the charge in designing and implementing cutting-edge SASE solutions, enhancing networking and cloud security for distributed environments. Collaborate with cross-functional teams to advance secu...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Lead maintenance operations to ensure optimal equipment and facility performance. Oversee a skilled team, manage budgets, and ensure compliance with safety standards while enhancing operational effici...

Yesterday

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$200K - $210K *

Drive operational excellence by leading a diverse team to enhance maintenance strategies, ensuring quality control and financial performance across a large portfolio while fostering a safety-first cul...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$79K - $112K *

Transform client relationships by leading participant communications strategies for large and not-for-profit markets. Drive engagement through multi-channel campaigns, ensuring client satisfaction and...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$231K - $250K *

Transform your career by leading complex commercial transactions and providing strategic legal counsel. Collaborate with cross-functional teams to mitigate risks and enhance compliance while managing...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.