Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$90K - $110K *
Collaborate with cross-functional teams to manage the full contract lifecycle, ensuring compliance and risk mitigation while negotiating agreements that align with business objectives and protect comp...
Yesterday
Remote Finance & Insurance Manager
$80K - $95K *
Join a dynamic team as you drive revenue growth through virtual Finance & Insurance sales. Lead the full sales process, enhance customer experiences, and achieve performance targets in a fast-paced, r...
Yesterday
F5 Advanced Web Application Firewall Engineer
$108K - $130K *
Transform enterprise web application security by engineering and managing F5 WAF policies. Collaborate with cybersecurity teams to enhance protection, tune policies, and respond to incidents, ensuring...
Yesterday
Shared Services Project Manager
$80K - $95K *
Transform patient access to specialty medications by leading implementation projects, optimizing workflows, and collaborating with clinical teams to enhance pharmacy experiences and resolve issues eff...
Yesterday
Principal Incident Response Engineer
$126K - $188K *
Unlock the potential of cybersecurity by leading risk management initiatives, enhancing security operations, and driving impactful projects. Collaborate globally to develop automation and metrics that...
Yesterday
Staff Software Development Engineer
$106K - $284K *
Lead the charge in designing and delivering secure, scalable microservices that enhance healthcare data exchange. Collaborate with cross-functional teams to ensure compliance and operational excellenc...
Yesterday
$80K - $95K *
Grow your career with a dynamic role overseeing construction projects, ensuring compliance with specifications and budgets. Lead inspections, manage contracts, and coordinate teams on diverse projects...
Yesterday
Pharmacy Eligibility/Claims Business Analyst
$54K - $145K *
Unlock potential by collaborating with cross-functional teams to deliver impactful analysis and requirements for Medicare and Medicaid enrollment solutions within an Agile framework, ensuring seamless...
Reposted yesterday
Principal Offensive Security Engineer
$183K - $200K *
Shape the future of offensive security by leading advanced penetration testing, red-team engagements, and AI-assisted workflows. Collaborate with cross-functional teams to enhance security measures an...
Yesterday
Senior External Reporting Accountant
$80K - $95K *
Take ownership of external financial reporting by preparing and consolidating quarterly statements, ensuring GAAP compliance, and enhancing reporting initiatives. Collaborate with leadership to delive...
Yesterday
Lead Project Assessor - Energy
$80K - $95K *
Transform building performance by conducting assessments and energy audits for diverse properties. Analyze systems, develop recommendations, and prepare reports to enhance efficiency and sustainabilit...
Yesterday
$145K - $175K *
Empower organizations to transform workflows with AI by architecting solutions that integrate Grok Build and Grok Bot. Collaborate with engineering teams and executives to drive adoption and optimize...
Yesterday
$95K - $115K *
Join a team that's dedicated to enhancing ERP solutions for colleges and universities. As a consultant, you'll collaborate on Ellucian Banner implementations, ensuring client needs are met within scop...
Reposted yesterday
Supervisory Information Technology Specialist (Operating Systems)
$95K - $115K *
Lead the Production Support Operations team by ensuring reliable IT systems, managing cloud technologies, and driving continuous improvement while overseeing staff and coordinating with stakeholders f...
Yesterday
Supervisory Information Technology Specialist (Operating Systems)
$95K - $115K *
Transform your career by leading IT operations, ensuring system reliability, and driving continuous improvement. Oversee a dedicated team while managing cloud technologies and infrastructure to suppor...
Yesterday
Senior Legal Compliance Manager
$110K - $130K *
Lead the charge in enhancing regulatory compliance across satellite operations, ensuring adherence to export controls, international trade laws, and corporate obligations while collaborating with cros...
Yesterday
$124K - $271K *
Drive transformative AI implementations by collaborating cross-functionally to deploy production-ready agents within 90 days, enhancing product scalability and accelerating revenue growth through hand...
Reposted yesterday
Technical Content Developer Associate Manager, AI POD
$73K - $182K *
Empower the future of AI learning by developing impactful technical content that enhances workforce skills. Collaborate with experts to create engaging courses and assessments, ensuring learners can a...
Yesterday
Senior Manager, Access Marketing
$180K - $200K *
Drive innovative marketing strategies to enhance access to healthcare products by collaborating with cross-functional teams and executing impactful initiatives that improve payer and provider engageme...
Reposted yesterday
$170K - $200K *
Grow your career with a strategic leadership role driving sales growth, shaping market strategies, and leading cross-functional teams to enhance customer value and expand market share in a dynamic env...
Yesterday
$90K - $140K *
Lead the charge in designing and implementing cutting-edge SASE solutions, enhancing networking and cloud security for distributed environments. Collaborate with cross-functional teams to advance secu...
Reposted yesterday
Senior Facilities & Maintenance Manager
$80K - $95K *
Lead maintenance operations to ensure optimal equipment and facility performance. Oversee a skilled team, manage budgets, and ensure compliance with safety standards while enhancing operational effici...
Yesterday
$200K - $210K *
Drive operational excellence by leading a diverse team to enhance maintenance strategies, ensuring quality control and financial performance across a large portfolio while fostering a safety-first cul...
Yesterday
Strategist Participant Communication
$79K - $112K *
Transform client relationships by leading participant communications strategies for large and not-for-profit markets. Drive engagement through multi-channel campaigns, ensuring client satisfaction and...
Yesterday
Associate General Counsel - Commercial
$231K - $250K *
Transform your career by leading complex commercial transactions and providing strategic legal counsel. Collaborate with cross-functional teams to mitigate risks and enhance compliance while managing...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.