Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Senior / Staff Product Manager - IoT Connected Devices
$180K - $248K *
Shape the future of connected devices as the product leader for in-field asset monitoring. Own the hardware roadmap, drive product introductions, and ensure reliability, directly influencing a key gro...
Reposted yesterday
$80K *
Empower clients by managing complex care needs through remote case management, ensuring access to high-quality treatment and support. Collaborate with multidisciplinary teams to enhance client engagem...
Reposted yesterday
$80K - $95K *
Join a team that's dedicated to transforming data into actionable insights. As a Senior Analyst, you'll tackle complex challenges, support strategic initiatives, and collaborate with experts to enhanc...
Yesterday
State Product Associate - Remote
$110K - $147K *
Analyze and contribute to local market strategies by researching regulatory conditions and trends. Collaborate across teams to ensure product compliance and support implementation, while effectively c...
Yesterday
$50K - $114K *
Transform financial operations by driving budgeting, forecasting, and reporting processes. Collaborate with stakeholders to ensure accuracy and alignment in workforce planning, while supporting leader...
Reposted yesterday
$120K - $145K *
Shape the future of healthcare technology by developing scalable AI solutions. Collaborate with experts to create impactful systems, enhancing user experiences and driving innovation in clinical data...
Yesterday
$105K - $141K *
Execute integrated marketing strategies that drive measurable growth by translating business priorities into actionable programs. Collaborate cross-functionally to enhance pipeline performance and lev...
Yesterday
Cornerstone Technical Consultant
$86K - $170K *
Unlock potential by driving Cornerstone technical implementations, enhancing HR and Learning practices. Collaborate with clients to gather requirements, design solutions, and ensure successful deploym...
Reposted yesterday
West Coast Business Development Director, Advanced Therapies (Cell and Gene Therapy)
$134K - $201K *
Inspire growth within the cell and gene therapy landscape by driving complex CDMO deal lifecycle, leveraging your expertise in CGT and forging senior relationships to accelerate innovative partnership...
Reposted yesterday
Cornerstone Technical Consultant
$86K - $170K *
Drive technical implementation of Cornerstone solutions, enhancing HR practices through agile methodologies. Collaborate with clients to gather requirements, design configurations, and ensure successf...
Reposted yesterday
$110K - $130K *
Empower product excellence by connecting teams and building systems that ensure reliability and efficiency. Drive customer insights, streamline operations, and enhance product launches in a hands-on...
Yesterday
$125K - $150K *
Lead the design and governance of compensation strategies, ensuring market competitiveness and compliance. Oversee a team to deliver innovative solutions that align with business objectives and enhanc...
Yesterday
Sales Pursuits and Activation Manager, Global Consulting Services
$110K - $130K *
Elevate sales excellence by guiding pursuit teams through lifecycle stages, enhancing strategies, and leveraging global resources to drive impactful market campaigns and client narratives...
Yesterday
Sales Pursuits and Activation Manager, Global Consulting Services
$110K - $130K *
Drive sales excellence by guiding pursuit teams through the lifecycle of complex deals, enhancing strategies, and leveraging global resources to create compelling narratives and market campaigns that...
Yesterday
Senior Website Manager, about.gitlab.com
$104K - $176K *
Lead the strategy and optimization for a high-traffic B2B website, aligning partners and driving performance through experimentation and content governance. Collaborate with cross-functional teams to...
Yesterday
$166K - $200K *
Help us deliver exceptional primary care services to Veterans by providing comprehensive clinical practice, consultation, and management within a collaborative healthcare team, ensuring quality and ti...
Yesterday
$80K - $95K *
Manage the preparation and review of diverse tax returns while mentoring a team. Embrace challenges in a fast-paced environment, ensuring accuracy and compliance with tax codes. Foster client relation...
Yesterday
$150K - $180K *
Unlock potential by leading multidisciplinary engineering teams to design and deploy complex power generation systems. Drive strategic initiatives, ensure technical excellence, and foster collaboratio...
Yesterday
Lead/Principal Product Manager, Tax Agents
$150K - $180K *
Drive the development of cutting-edge AI tax agents, collaborating with engineers and clients to enhance efficiency and transform tax practices across the industry. Shape product strategy and deliver...
Yesterday
$100K - $120K *
Empower our growth by driving transportation sales, managing key accounts, and executing strategic initiatives to enhance our bundled service offerings while collaborating with cross-functional teams...
Yesterday
$132K - $193K *
Unlock potential by architecting complex analytics solutions, mentoring analysts, and collaborating with senior stakeholders to deliver impactful insights across multiple domains, ensuring high standa...
Yesterday
Team8 Stealth Cyber Startup- Sales Development Representative
$85K - $110K *
Explore your potential in a dynamic role driving outbound outreach and building relationships. You'll engage with security leaders, turning interest into qualified meetings while collaborating closely...
Yesterday
Higher Education Growth Leader
$160K - $170K *
Transform the Higher Education landscape by driving growth and business development. Lead a dedicated team, build strategic relationships, and shape impactful solutions while collaborating with senior...
Yesterday
Executive Director of Special Services, 2027-28
$95K - $115K *
Help us lead and innovate special services for PreK-12 students, ensuring compliance and effective support for diverse educational needs while fostering collaboration and growth across the district...
Yesterday
Enterprise Customer Success Manager
$150K - $160K *
Empower enterprise customers by managing onboarding, adoption, and expansion strategies. Collaborate with sales and technical teams to ensure successful implementations and drive measurable outcomes f...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.