Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$180K - $248K *

Shape the future of connected devices as the product leader for in-field asset monitoring. Own the hardware roadmap, drive product introductions, and ensure reliability, directly influencing a key gro...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$80K *

Empower clients by managing complex care needs through remote case management, ensuring access to high-quality treatment and support. Collaborate with multidisciplinary teams to enhance client engagem...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to transforming data into actionable insights. As a Senior Analyst, you'll tackle complex challenges, support strategic initiatives, and collaborate with experts to enhanc...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $147K *

Analyze and contribute to local market strategies by researching regulatory conditions and trends. Collaborate across teams to ensure product compliance and support implementation, while effectively c...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$50K - $114K *

Transform financial operations by driving budgeting, forecasting, and reporting processes. Collaborate with stakeholders to ensure accuracy and alignment in workforce planning, while supporting leader...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Shape the future of healthcare technology by developing scalable AI solutions. Collaborate with experts to create impactful systems, enhancing user experiences and driving innovation in clinical data...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$105K - $141K *

Execute integrated marketing strategies that drive measurable growth by translating business priorities into actionable programs. Collaborate cross-functionally to enhance pipeline performance and lev...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$86K - $170K *

Unlock potential by driving Cornerstone technical implementations, enhancing HR and Learning practices. Collaborate with clients to gather requirements, design solutions, and ensure successful deploym...

Reposted yesterday

  •   Less than 5 years exp.  •   Business Services

$134K - $201K *

Inspire growth within the cell and gene therapy landscape by driving complex CDMO deal lifecycle, leveraging your expertise in CGT and forging senior relationships to accelerate innovative partnership...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$86K - $170K *

Drive technical implementation of Cornerstone solutions, enhancing HR practices through agile methodologies. Collaborate with clients to gather requirements, design configurations, and ensure successf...

Reposted yesterday

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Empower product excellence by connecting teams and building systems that ensure reliability and efficiency. Drive customer insights, streamline operations, and enhance product launches in a hands-on...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Lead the design and governance of compensation strategies, ensuring market competitiveness and compliance. Oversee a team to deliver innovative solutions that align with business objectives and enhanc...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Elevate sales excellence by guiding pursuit teams through lifecycle stages, enhancing strategies, and leveraging global resources to drive impactful market campaigns and client narratives...

Yesterday

  •   8 - 10 years exp.  •   Business Services

$110K - $130K *

Drive sales excellence by guiding pursuit teams through the lifecycle of complex deals, enhancing strategies, and leveraging global resources to create compelling narratives and market campaigns that...

Yesterday

  •   8 - 10 years exp.  •   Business Services

$104K - $176K *

Lead the strategy and optimization for a high-traffic B2B website, aligning partners and driving performance through experimentation and content governance. Collaborate with cross-functional teams to...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$166K - $200K *

Help us deliver exceptional primary care services to Veterans by providing comprehensive clinical practice, consultation, and management within a collaborative healthcare team, ensuring quality and ti...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Manage the preparation and review of diverse tax returns while mentoring a team. Embrace challenges in a fast-paced environment, ensuring accuracy and compliance with tax codes. Foster client relation...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Legal & Accounting

$150K - $180K *

Unlock potential by leading multidisciplinary engineering teams to design and deploy complex power generation systems. Drive strategic initiatives, ensure technical excellence, and foster collaboratio...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Energy & Utilities

$150K - $180K *

Drive the development of cutting-edge AI tax agents, collaborating with engineers and clients to enhance efficiency and transform tax practices across the industry. Shape product strategy and deliver...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Empower our growth by driving transportation sales, managing key accounts, and executing strategic initiatives to enhance our bundled service offerings while collaborating with cross-functional teams...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$132K - $193K *

Unlock potential by architecting complex analytics solutions, mentoring analysts, and collaborating with senior stakeholders to deliver impactful insights across multiple domains, ensuring high standa...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$85K - $110K *

Explore your potential in a dynamic role driving outbound outreach and building relationships. You'll engage with security leaders, turning interest into qualified meetings while collaborating closely...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$160K - $170K *

Transform the Higher Education landscape by driving growth and business development. Lead a dedicated team, build strategic relationships, and shape impactful solutions while collaborating with senior...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Help us lead and innovate special services for PreK-12 students, ensuring compliance and effective support for diverse educational needs while fostering collaboration and growth across the district...

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$150K - $160K *

Empower enterprise customers by managing onboarding, adoption, and expansion strategies. Collaborate with sales and technical teams to ensure successful implementations and drive measurable outcomes f...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.