Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$150K - $180K *

Lead the charge in driving sales growth and market leadership for Digital Plant solutions. Collaborate with teams to develop strategies, manage key accounts, and ensure high-quality project delivery w...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$90K - $110K *

Transform digital plant projects through effective management, ensuring successful delivery while overseeing scope, budget, and client satisfaction. Collaborate with teams to drive project success and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$95K - $115K *

Lead the successful delivery of automation projects by managing scope, budget, and client expectations. Collaborate with teams to ensure project profitability and client satisfaction while maintaining...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$150K - $180K *

Join a team that's redefining customer success by leveraging AI to enhance the post-sale journey. Lead and scale a dynamic team while driving retention and expansion for enterprise clients in a fast-p...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$123K - $207K *

Champion the design and ownership of a robust People Data Access & Governance framework, ensuring responsible data access while partnering with cross-functional teams to navigate compliance and ethica...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$88K - $105K *

Manage the end-to-end onboarding of healthcare clients, leading cross-functional teams to ensure smooth transitions into coding and billing services while driving operational improvements and maintain...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $195K *

Drive the development and execution of strategic projects for radioisotope production facilities. You will lead cross-functional teams to ensure operational readiness, regulatory compliance, and succe...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Partner with us to design and implement cloud-native data solutions, ensuring secure and reliable data exchange across platforms. Collaborate with teams to enhance data accessibility and support advan...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to advanced support for industrial control systems. As a key escalation point, you'll tackle complex issues, drive system stability, and mentor junior staff in a dynamic 2...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$240K - $300K *

Empower strategic partnerships across the Eastern U.S. to drive revenue growth. Build and manage a partner-sourced pipeline, enhance customer engagement, and accelerate deal closures through collabora...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$98K - $153K *

Grow your career with a leadership role focused on wholesaler management, driving sales and market share through team development and strategic planning. Collaborate with national accounts to achieve...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$160K - $195K *

Innovate with us to develop and deploy cutting-edge AI solutions that enhance advertising measurement products. Collaborate across teams to drive impactful data-driven decisions and expand our capabil...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$83K - $87K *

Elevate your career by ensuring the reliability of industrial electrical systems. Utilize your expertise to troubleshoot, maintain, and enhance electrical infrastructure while adhering to safety stand...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Lead the charge in driving trailer sales and leasing operations, overseeing team performance, managing P&L, and cultivating customer relationships to achieve strategic growth and operational excellenc...

1 week ago

  •   11 - 15 years exp.  •   Food & Beverages

$120K - $145K *

Empower your career by leading data architecture initiatives across Oracle Cloud applications. Drive data governance, migration, and integration strategies to enhance business processes and ensure dat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$150K - $180K *

Drive brand engagement and innovation through strategic partnerships, workshops, and marketing campaigns, leveraging HP digital print technology to inspire growth and creativity in collaboration with...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$180K - $215K *

Transform your career by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster strong cus...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Inspire growth by leading regional launch strategies and building high-performing sales teams. Drive market success through strong customer relationships and cross-functional collaboration in a fast-p...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Transform project delivery by leading multidisciplinary design coordination for complex industrial projects, ensuring seamless integration between clients, engineering teams, and external partners thr...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$80K - $95K *

Unlock your potential by managing sourcing and procurement for electrical projects. Collaborate with teams to ensure timely delivery of materials while mitigating risks and maintaining quality standar...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$155K - $185K *

Champion growth and customer marketing by leading a dynamic team to drive full-funnel strategies, optimize campaigns, and leverage AI tools for enhanced performance and insights. Shape the future of m...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$200K - $225K *

Elevate customer operations by leading Loan Fulfillment, Customer Experience, and Collections teams. Drive efficiency, enhance applicant experiences, and manage vendor relationships to ensure a seamle...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$180K - $220K *

Join a team that's dedicated to enhancing primary care for Veterans. Lead clinical initiatives, supervise staff, and engage in quality improvement projects while providing comprehensive patient care i...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$145K - $165K *

Drive your career by owning the end-to-end data platform, designing and maintaining scalable pipelines and infrastructure. Collaborate with analytics teams to ensure data quality and governance while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$98K - $172K *

Inspire patient care excellence by providing pharmaceutical services, counseling, and immunizations. Engage with the community and ensure compliance while leading pharmacy staff in delivering top-notc...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.