Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $116,335
Director II Capture & Proposal Public Sector (SLED)
$163K - $218K *
Empower your career by leading SLED capture and proposal strategies. Drive growth and engage diverse teams in this pivotal role, shaping public sector outcomes through innovative procurement and partn...
Reposted 1 week ago
$122K - $261K *
Elevate employee experiences by leading digital transformation initiatives, providing strategic guidance, and implementing scalable solutions across enterprise environments to enhance productivity and...
1 week ago
Senior People Business Partner
$106K - $185K *
Partner with us to drive strategic talent management initiatives, enhance employee engagement, and foster a culture of collaboration within the Go-To-Market and Sales functions, ensuring alignment wit...
1 week ago
$80K - $95K *
Elevate financial integrity by leading accounting operations, ensuring compliance, and driving efficiency across departments. Collaborate with teams to deliver accurate financial reporting and support...
1 week ago
Solutions Engineer - Agents & Automation
$150K - $200K *
Unlock potential by driving enterprise agent solutions with Microsoft technologies. Collaborate on agent governance, lifecycle management, and secure operations, while translating designs into product...
1 week ago
$110K - $130K *
Empower business leaders by building financial models and analyses that drive strategic decisions. Collaborate across teams to evaluate opportunities, support fundraising, and present insights to seni...
1 week ago
$160K - $200K *
Shape the future of Investor Relations by developing and executing impactful strategies to enhance communication with the investment community, drive corporate strategy alignment, and maximize shareho...
Reposted 1 week ago
Marketing & Communications Manager
$80K - $95K *
Reimagine the Caribbean brand narrative by leading strategic marketing initiatives, driving impactful campaigns, and fostering partnerships to enhance guest experiences and elevate brand presence acro...
1 week ago
Manager, Manufacturing Support Engineering
$110K - $130K *
Empower the Manufacturing Support Engineering team to ensure 24/7 equipment readiness through effective maintenance, troubleshooting, and collaboration, while upholding safety and compliance standards...
1 week ago
Pharmaceutical Development Scientist II
$95K - $115K *
Join a team that's dedicated to advancing pharmaceutical development. This role focuses on formulation and process design for oral solid dosage forms, ensuring compliance and quality in clinical trial...
1 week ago
$150K - $180K *
Lead the technology vision and strategy, driving innovation and operational excellence across infrastructure, applications, and cybersecurity while fostering a culture of service and continuous improv...
1 week ago
Principal Developer (MES/Ignition)
$120K - $145K *
Innovate cutting-edge software solutions by leveraging advanced programming skills, designing intuitive user interfaces, and ensuring project success through Agile methodologies and technical oversigh...
1 week ago
GRC Engineer (Governance Risk and Compliance)
$115K - $140K *
Drive GRC initiatives by building and testing security controls, assessing risks, and automating evidence collection. Collaborate with teams to enhance compliance and support audits while ensuring eff...
1 week ago
$118K - $157K *
Transform manufacturing operations by leading teams to enhance safety, productivity, and cost-effectiveness while driving continuous improvement and compliance with regulations. Join a team that's com...
1 week ago
$86K - $209K *
Drive the design, implementation, and maintenance of advanced grid technology systems, ensuring real-time operational support for electric distribution. Collaborate with teams to enhance system functi...
1 week ago
Senior Talent Acquisition Partner | Executive Search
$150K - $180K *
Join a dynamic team to lead executive searches across multiple functions, driving the full-cycle recruitment process for senior leadership roles. Collaborate with executives to refine strategies and e...
Reposted 1 week ago
Cardiovascular Specialist, Health and Science Professional - Columbia, MO
$76K - $199K *
Elevate sales and customer relationships by engaging effectively with healthcare providers. Utilize analytical skills and digital tools to drive strategic business development and promote breakthrough...
1 week ago
Sr Regional Oncology Business Manager, Nashville
$130K - $160K *
Unlock potential by driving sales and education in oncology medical devices. Collaborate with healthcare professionals to enhance treatment options for liver and pancreatic cancer while achieving regi...
1 week ago
$200K - $225K *
Transform the future of cloud commerce by leading the design and evolution of scalable, resilient systems that enhance platform reliability and drive innovation across teams and products...
1 week ago
Sr. Manager Aetna Account Management
$82K - $182K *
Drive customer success by managing relationships and articulating Aetna's technology value across diverse markets. Collaborate with teams to enhance client engagement and satisfaction through innovati...
Reposted 1 week ago
District Support Pharmacist Full Time
$124K - $157K *
Lead the charge in transforming health care by supporting pharmacy teams, ensuring safe dispensing, and enhancing patient experiences. Collaborate across districts to deliver exceptional care and upho...
Reposted 1 week ago
Senior Data Engineer (Analytics & Applied AI)
$113K - $188K *
Lead the charge in building robust data platforms that transform complex datasets into actionable insights. This senior role demands expertise in software and data engineering, with a focus on quality...
1 week ago
National Account Manager- The Home Depot
$118K - $140K *
Shape strategic account management and drive revenue growth through effective collaboration and negotiation. Leverage data analytics to enhance customer relationships and ensure operational excellence...
1 week ago
$159K - $188K *
Pioneer innovative strategies in wealth management, enhancing client relationships over $10MM net worth. Collaborate with specialists to address comprehensive wealth planning, estate needs, and busine...
Reposted 1 week ago
Senior Enterprise Account Executive
$119K - $140K *
Drive strategic outbound sales efforts to secure new enterprise accounts, leveraging your expertise in solution selling and relationship building with C-suite executives to expand market presence and...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.