Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $116,335
Senior Specialist, Physical Security Systems & Services - Remote
$95K - $115K *
Optimize physical security applications and operations. Lead system management, support incident response, and enhance security measures across the enterprise. Collaborate with stakeholders to ensure...
1 week ago
$110K - $130K *
Take ownership of a high-performing team in Client Operations, driving service quality and continuous improvement. Collaborate across functions to enhance client experience and operational efficiency...
1 week ago
Principal Researcher, Benchmarks, Evaluation, and Standards
$133K - $197K *
Drive impactful research by leading technical evaluations and benchmarks in AI. Collaborate with diverse stakeholders to ensure principled guidance that integrates social and technical considerations...
1 week ago
$80K - $95K *
Join a dynamic Infrastructure team to design, implement, and manage secure, reliable networks. Enhance connectivity and performance across local and wide area networks while troubleshooting and optimi...
1 week ago
Contract Salesforce Developer/Admin
$85K - $109K *
Join us to lead a Salesforce centralization initiative, merging environments and enhancing workflows. Collaborate with stakeholders to create scalable solutions, ensuring a secure and maintainable Sal...
1 week ago
$80K - $95K *
Elevate your marketing career by leading integrated organic campaigns that drive engagement and revenue growth. Collaborate cross-functionally to optimize strategies across social media, email, and ac...
1 week ago
Remote Breast Radiologist - RP Eagle
$250K - $300K *
Partner with us to provide expert breast imaging interpretation in a fully remote setting. Enjoy flexible scheduling and a supportive team environment while contributing to exceptional patient care ac...
1 week ago
$70K - $122K *
Advance your career by managing a functional team, overseeing daily operations, and resolving technical issues. Lead client projects, implement best practices, and foster staff development while ensur...
1 week ago
AI Infrastructure Consulting Engineer - Converged Compute & Storage
$77K - $108K *
Join a dynamic team to design and implement high-performance AI infrastructure solutions, ensuring client satisfaction through expert delivery and support of complex compute and storage systems for en...
1 week ago
$120K - $135K *
Lead the charge in full-funnel paid social strategy, execution, and optimization for high-growth clients. Collaborate with teams to deliver integrated marketing solutions and drive measurable business...
Reposted 1 week ago
Staff Software Engineer - 340B Check
$170K - $200K *
Lead technical direction for a healthcare data team, driving architectural decisions and cross-team initiatives to enhance compliance and operational efficiency. Elevate team performance while solving...
1 week ago
Senior Data Scientist II, Core & Agentic Automation
$183K - $216K *
Unlock your potential by leading data science initiatives that drive impactful decision-making and enhance analytical frameworks across teams, ensuring rigorous performance standards and scalable self...
1 week ago
$155K - $170K *
Lead the charge in architecting scalable Salesforce solutions, driving platform strategy, and ensuring high-quality integrations across KIPP's national ecosystem. Collaborate with stakeholders to deli...
1 week ago
Spend Management Account Executive
$85K - $113K *
Engage with finance leaders to drive growth in our client base, leveraging your FinTech expertise. Collaborate with a dynamic sales team to refine strategies and exceed sales quotas while promoting in...
1 week ago
Business Development Manager- Data Centers Midwest
$80K - $100K *
Lead the charge in developing high-performance building specifications for Data Center projects. Engage with key influencers and coordinate with sales teams to drive growth and enhance product selecti...
1 week ago
Technical Solutions Manager - Life Sciences
$135K - $160K *
Lead the charge in delivering innovative DCS solutions for Life Sciences. Serve as the technical expert, driving automation strategies and ensuring compliance with regulations to support growth and ex...
Reposted 1 week ago
Portfolio Manager-Asset Based Lending
$148K - $174K *
Advance customer relationships and drive business growth by managing a diverse portfolio of ABL credit accounts. Collaborate across teams to monitor risk, ensure compliance, and execute credit needs w...
Reposted 1 week ago
Technical Success Manager- Central
$100K - $120K *
Elevate customer success by leveraging technical expertise and advocacy to drive adoption of cybersecurity solutions, ensuring measurable outcomes and risk reduction through strategic partnerships wit...
1 week ago
Technical Support Manager, Billing - Remote US, ET or CT
$75K - $100K *
Manage day-to-day billing operations and client support in the energy sector. Lead client interactions, troubleshoot technical issues, and collaborate with internal teams to enhance service delivery a...
1 week ago
$90K - $150K *
Join a team that's dedicated to excellence in automotive repair and maintenance. Leverage your expertise to build customer loyalty through effective diagnostics and repairs while enjoying a supportive...
1 week ago
Procurement and Expediting Manager - Lake City Microgrid and CHP
$95K - $115K *
Optimize procurement processes and vendor management for industrial projects. Collaborate with teams to ensure timely delivery of equipment and materials, while maintaining compliance with safety and...
1 week ago
Design and Submittal Manager - Lake City Microgrid and CHP
$100K - $120K *
Lead multidisciplinary design management for industrial power projects. Own submittal processes, coordinate reviews, and ensure compliance with design interfaces and approvals to drive project success...
1 week ago
$69K - $101K *
Champion the reliability of automated systems by providing expert technical support, troubleshooting complex issues, and collaborating cross-functionally to ensure operational excellence and seamless...
1 week ago
Contracts and Change Manager - Lake City Microgrid and CHP
$95K - $115K *
Drive project success by managing contracts and changes for federal construction, ensuring compliance and timely documentation while collaborating with stakeholders to maintain project integrity and e...
1 week ago
Deputy Project Manager and EPC Interface Manager - Lake City Microgrid and CHP
$100K - $120K *
Join us in managing complex EPC interfaces and project execution for a critical microgrid initiative. Collaborate across teams to ensure timely delivery and adherence to safety standards while standin...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.