Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $116,335
Biotech Project Leadership - Clinical Trials - Home- Based
$110K - $130K *
Lead global clinical studies across diverse therapeutic areas, ensuring operational excellence and client satisfaction through effective project management and team leadership...
1 week ago
Environmental Consulting Project Director
$202K - $289K *
Champion growth in environmental services by leading business development, managing complex projects, and fostering client relationships in the power industry. Leverage your expertise to navigate regu...
1 week ago
Senior Transmission Line Engineer 1 - Grid
$84K - $129K *
Drive the design and development of high-voltage transmission lines, overseeing project teams and ensuring compliance with engineering standards while collaborating with clients and vendors to deliver...
1 week ago
Lead Transmission Line Engineer 1 - Grid
$118K - $180K *
Join a dynamic team to design high-voltage transmission lines, mentor peers, and ensure compliance with engineering standards. Leverage your expertise to deliver innovative solutions and enhance clien...
1 week ago
Dedicated Flight Coordinator - South Florida
$50K - $500K *
Grow your career with a dynamic team as you coordinate aircraft scheduling, ensuring seamless communication and logistics for clients and flight crews while adhering to safety regulations and operatio...
1 week ago
Senior Contact Center Engineer
$93K - $150K *
Support and optimize cloud-based contact center platforms, ensuring service availability and excellent customer experience. Collaborate with teams to troubleshoot complex issues and enhance operationa...
1 week ago
Enterprise Strategist – Chief Architect - AI
$168K - $240K *
Champion AI strategy and governance by leading advisory consulting services, guiding clients from interest to practical adoption. Collaborate with technical teams to deliver integrated solutions and e...
1 week ago
Principal Consultant, Environmental FERC Project Manager
$110K - $130K *
Drive strategic leadership for complex energy projects, ensuring compliance and stakeholder engagement while managing multi-site environmental permitting and regulatory processes across the U.S. Lead...
1 week ago
Senior Director, Pricing Analytics
$150K - $180K *
Drive revenue performance by leading pricing strategy and analytics across brands and properties. Collaborate with cross-functional teams to modernize forecasting and reporting capabilities, leveragin...
1 week ago
Revenue Assurance Senior Analyst
$75K - $88K *
Analyze financial compliance and revenue accuracy across franchise operations, ensuring adherence to standards through audits and validations. Serve as a key subject matter expert, guiding franchisees...
1 week ago
Staff Software Engineer, Consumer 360
$154K - $227K *
Join a dynamic team as a technical leader, driving scalable software solutions and mentoring engineers. Collaborate across teams to enhance engineering practices and deliver innovative AI-driven appli...
1 week ago
Executive Assistant - Bellevue
$93K - $109K *
Innovate alongside executives by providing strategic support to drive organizational success, manage high-stakes priorities, and enhance workflow efficiency. You'll serve as a vital liaison and truste...
Reposted 1 week ago
Enterprise Customer Success Manager (United States - Remote)
$110K - $130K *
Unlock customer potential by driving engagement and satisfaction throughout their journey. Manage accounts, foster relationships, and ensure value realization to support retention and growth in a dyna...
1 week ago
Senior Product Software Engineer - AI
$92K - $161K *
Engineer innovative AI solutions by collaborating with cross-functional teams to develop customer-centric features that enhance accounting workflows. Drive technical leadership and agile practices in...
1 week ago
Retail Media Manager - Remote in US, Canada or UK
$90K - $110K *
Lead the charge in driving Amazon advertising strategy to enhance revenue and brand presence. Collaborate across teams to optimize campaigns, manage budgets, and leverage data insights for impactful m...
1 week ago
Director, Marketing AI & GTM Automation
$180K - $270K *
Transform marketing strategies by leading AI and automation initiatives across go-to-market operations. Drive innovation, governance, and team development while ensuring measurable impact on revenue a...
1 week ago
$99K - $138K *
Champion innovative solutions as you drive partner adoption of our lending platform. Collaborate across teams to analyze deal economics and translate insights into actionable strategies that enhance p...
1 week ago
$145K - $150K *
Lead the charge in developing web-based dissemination tools for external users, collaborating with developers to enhance data visualization and streamline CI/CD processes using modern frameworks and b...
1 week ago
$75K - $158K *
Unlock potential by serving as a key Business Analyst/Product Manager in a Scaled Agile environment, translating business objectives into actionable features and capabilities, while collaborating acro...
1 week ago
Director, Social and Influencer
$45K - $165K *
Engage as a strategic leader in social and influencer marketing, driving brand presence across channels. Oversee a dynamic team, blending creativity with measurable impact while navigating trends and...
1 week ago
$110K - $130K *
Advance client relationships and team performance as a strategic leader, overseeing captive insurance operations, driving excellence, and enhancing service delivery while managing complex engagements...
1 week ago
Associate Demand Generation Manager
$110K - $130K *
Elevate our demand generation efforts by orchestrating targeted marketing strategies that engage key accounts in the Corporate Tech sector. Collaborate with leadership to drive pipeline growth and enh...
1 week ago
District Pharmacy Supervisor - Relocation Available
$100K - $120K *
Oversee retail pharmacy operations across assigned districts, ensuring compliance, quality patient care, and profitability. Drive performance improvement, manage talent development, and maintain high...
1 week ago
Principal Client Account Lead - Atlanta
$125K - $150K *
Drive growth at a large strategic account by delivering AI & Data solutions. Engage closely with executives, align teams, and ensure client satisfaction while leading impactful programs in Retail, CPG...
Reposted 1 week ago
Americas Sales Business Partner Manager
$116K - $171K *
Unlock potential by driving sales strategy and operational excellence across teams. Collaborate with senior leaders to translate business goals into actionable plans, ensuring alignment and measurable...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.