Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$88K - $110K *

Join a team that's dedicated to enhancing healthcare professional engagements through effective coordination and support. This role involves managing peer-to-peer education programs and ensuring compl...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Champion women's health by providing expert midwifery care in a collaborative, supportive environment. Enjoy a balanced work-life with a four-day week and mentorship opportunities while delivering at...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$107K - $178K *

Champion compliance excellence by ensuring adherence to NERC standards, guiding operational risk management, and supporting audit preparations. Collaborate with teams to enhance compliance programs an...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Energy & Utilities

$122K - $292K *

Empower your career by leading advanced analytics to transform data into actionable insights. Collaborate with cross-functional teams to drive strategic decisions and enhance brand and consumer initia...

Today

  •   8 - 10 years exp.  •   Business Services

$80K - $120K *

Contribute to customer success by developing technical expertise across platforms, integrations, and operational processes. Collaborate with teams to resolve issues and enhance solutions, while gainin...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $140K *

Lead the charge in transforming legacy data into streamlined, AI-driven migrations. Own end-to-end processes, automate validation, and enhance efficiency while ensuring data integrity and accuracy for...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Join a dynamic team to design and optimize data pipelines, ensuring quality and security for analytics and AI capabilities. Collaborate with cross-functional teams to deliver innovative data solutions...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Engage in comprehensive program management for data center operations, ensuring seamless transitions from construction to live operations. Shape maintainability, drive incident improvements, and enhan...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$149K - $166K *

Lead the charge in advancing cutting-edge mechanical engineering solutions for high-performance electronics in space systems. Collaborate with cross-functional teams to deliver innovative designs that...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Aerospace & Defense

$95K - $115K *

Transform patient care by delivering advanced palliative services in home settings. Collaborate with an interdisciplinary team to enhance quality of life for patients facing complex medical challenges...

Today

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Empower patients by delivering advanced palliative care in their homes, collaborating with an interdisciplinary team to enhance quality of life while managing complex medical needs and guiding familie...

Today

  •   Less than 5 years exp.  •   Healthcare

$85K - $105K *

Unlock potential by leading clinical care as a BCBA, developing RBTs, and partnering with families to deliver impactful ABA services. Join a supportive team focused on quality and continuous improveme...

Today

  •   Less than 5 years exp.  •   Healthcare

$85K - $105K *

Champion clinical excellence as a BCBA, leading care for clients, mentoring RBTs, and collaborating with families. Drive impactful change while advancing your career in a supportive environment focuse...

Today

  •   Less than 5 years exp.  •   Healthcare

$85K - $105K *

Empower clinical excellence by leading ABA services, developing RBTs, and collaborating with families. Drive impactful treatment plans and foster a culture of quality care within a supportive team env...

Today

  •   Less than 5 years exp.  •   Healthcare

$85K - $105K *

Join our dynamic clinical team as a BCBA, leading client care, developing RBTs, and collaborating with families to make a meaningful impact in the lives of children with autism. Grow your career in a...

Today

  •   Less than 5 years exp.  •   Healthcare

$85K - $105K *

Elevate your career with a Board Certified Behavior Analyst role, leading clinical care, developing RBTs, and partnering with families to make a meaningful impact in the lives of children with autism...

Today

  •   Less than 5 years exp.  •   Healthcare

$85K - $105K *

Grow your career with us as you lead clinical care, develop RBTs, and partner with families to make a meaningful impact in the lives of children with autism. Join a supportive team focused on clinical...

Today

  •   Less than 5 years exp.  •   Healthcare

$92K - $120K *

Join a team that's driving sales growth by engaging partners and employers in the employee benefits sector. This role focuses on developing relationships, presenting solutions, and achieving performan...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Drive revenue growth by selling mission-critical call handling solutions to public safety organizations. Build relationships, understand needs, and modernize 9-1-1 environments through consultative sa...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$175K - $210K *

Lead the North American high-tech sales strategy, driving revenue growth and team performance while building executive relationships and executing complex enterprise sales in a dynamic market...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Consumer Technology

$86K - $138K *

Empower cloud infrastructure management by optimizing AWS environments, automating tasks, and ensuring security compliance. Collaborate with cross-functional teams to enhance operational efficiency an...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

$104K - $166K *

Shape the future of cybersecurity by leading vulnerability management initiatives, enhancing security posture, and driving remediation efforts across diverse environments. Collaborate with teams to en...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Aerospace & Defense

$104K - $166K *

Take ownership of cybersecurity initiatives by managing complex projects, ensuring compliance with federal regulations, and leading a team of experts to enhance incident response and information assur...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Aerospace & Defense

$146K - $234K *

Lead the charge in shaping federal IT programs by leveraging your DOJ or DEA experience. Collaborate with a team of experts to drive proposal development and manage complex projects in a dynamic envir...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Aerospace & Defense

$92K - $115K *

Drive successful client implementations by managing projects from inception to deployment. Collaborate cross-functionally to ensure timely, on-budget delivery while interfacing with stakeholders and v...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.