Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Senior Software Engineer Microsoft Development Platform (DoD Programs)
$120K - $145K *
Pioneer innovative software solutions for defense programs by leveraging your expertise in C#, .NET, and SQL Server. Collaborate with cross-functional teams to ensure secure, compliant, and high-quali...
1 week ago
Senior SAS/Python Model Validation and Modernization Developer
$85K - $95K *
Elevate your career by validating and modernizing statistical models using SAS and Python. Collaborate with analysts and stakeholders to enhance analytical systems and ensure accuracy in mission-criti...
1 week ago
Account Manager, Minerals and Nutrients
$130K - $150K *
Accelerate growth by managing sales strategies across CA and parts of the Midwest. Lead market development efforts, achieve sales goals, and collaborate with cross-functional teams to enhance customer...
1 week ago
ERP Module Lead - General Ledger
$80K - $100K *
Elevate your career by leading the charge in General Ledger and financial accounting for a cloud ERP implementation. Collaborate across campuses to ensure seamless integration and alignment of financi...
1 week ago
Full Stack eCommerce Developer (.NET/C#)
$95K - $115K *
Transform enterprise eCommerce solutions by leveraging .NET/C# and Optimizely. Collaborate with cross-functional teams to deliver scalable, high-performing B2B and B2C commerce applications that enhan...
1 week ago
$125K - $200K *
Unlock your potential by driving new business growth in a dynamic sales role. Engage with customers, build relationships, and develop strategic plans to expand market presence across North and South C...
1 week ago
$68K - $92K *
Join a team that's dedicated to delivering exceptional culinary experiences. Oversee the culinary department, create innovative menus, and ensure top-notch service while managing food preparation and...
1 week ago
$125K - $150K *
Elevate your career by leading civil site projects in the energy sector. Collaborate with a dynamic team to design, coordinate, and manage impactful utility projects while ensuring compliance with loc...
1 week ago
Project Leadership - Biotech (clinical trials) -Dermatology - Home Based
$110K - $130K *
Drive excellence in global clinical study leadership across various therapeutic areas. Collaborate with teams to deliver projects on time and within budget while exceeding client expectations...
Reposted 1 week ago
Principal Product Manager, Buyer Products
$150K - $180K *
Join a team that's redefining the buyer experience in B2B software. As a Principal Product Manager, you'll lead strategy, drive product delivery, and enhance buyer trust across multiple platforms, ens...
1 week ago
Sr. Medical Science Liaison- Appalachia Region
$166K - $205K *
Elevate your career as a Senior Medical Science Liaison, driving scientific exchange and collaboration with healthcare providers in oncology. Build relationships, support clinical initiatives, and con...
1 week ago
Director, Care Delivery Learning & Development
$161K - $202K *
Unlock potential by leading a dynamic Learning & Development team to enhance clinical and non-clinical training programs, ensuring high-quality patient care through innovative strategies and scalable...
1 week ago
SMB Account Executive - Sales, New Logo
$85K - $90K *
Engage with SMB accounts to build pipeline and close value-driven deals. Own your territory, manage sales cycles, and leverage data to drive results. Collaborate across teams to connect solutions with...
1 week ago
$80K - $95K *
Empower growth by developing strategic relationships with biotech and pharma clients. Drive market awareness and increase RFPs through collaboration with the business development team, leveraging your...
1 week ago
Procurement Manager, Process & Policy
$93K - $159K *
Advance your career by developing and standardizing Procurement processes that enhance compliance and efficiency. Collaborate with cross-functional teams to create clear documentation and governance p...
1 week ago
$110K - $130K *
Elevate your career by implementing and supporting AWS cloud solutions in a dynamic environment. Collaborate with experts to optimize performance and ensure secure, scalable infrastructure for federal...
1 week ago
Application Packaging Engineer
$116K - $122K *
Deliver reliable application packaging solutions for a large federal IT environment. Collaborate with stakeholders to gather requirements and ensure seamless deployment across thousands of endpoints...
1 week ago
Senior Water/Wastewater Seller-Doer
$110K - $130K *
Drive growth in water/wastewater markets by building client relationships and leading project teams. Leverage technical expertise to enhance project delivery and client satisfaction while expanding ma...
1 week ago
Senior Service Delivery Manager
$96K - $145K *
Transform service delivery for complex accounts by ensuring SLAs and KPIs are met. Lead governance, performance management, and continuous improvement initiatives while building trusted relationships...
1 week ago
Insights Manager - Health & Life Sciences (Remote, US-based only)
$75K - $90K *
Unlock potential by leading data analysis and storytelling efforts, ensuring insights meet client needs. Collaborate with teams to deliver actionable reports and maintain high-quality standards throug...
1 week ago
$80K - $95K *
Drive your career forward by cultivating client relationships and exceeding sales goals. As a key player, you'll develop marketing strategies, engage decision-makers, and provide tailored solutions to...
1 week ago
$225K - $250K *
Transform operations by leading a diverse team to enhance profitability and efficiency across multiple sites, while building strategic relationships with clients and driving growth initiatives in the...
1 week ago
$90K - $108K *
Drive successful project execution by managing customer projects from quotation to completion. Collaborate with teams and stakeholders to ensure timely delivery, quality standards, and customer satisf...
1 week ago
$195K - $215K *
Lead the charge in brand strategy, inspiring teams and fostering innovative solutions in a dynamic healthcare advertising environment, focused on advancing compelling communications and effective clie...
Reposted 1 week ago
$95K - $115K *
Transform security protocols by designing, implementing, and managing comprehensive systems to safeguard data integrity, conduct risk assessments, and enhance incident response capabilities while ensu...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.