Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$148K - $164K *

Optimize cloud security operations by monitoring and securing Azure and AWS environments. Collaborate with teams to integrate security into deployment pipelines and ensure compliance with industry sta...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Manage and maintain advanced telecommunications systems, ensuring secure and efficient voice and data communications. Collaborate with teams to provide technical support and training while overseeing...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Join a team that's dedicated to enhancing enterprise software solutions by investigating complex issues, collaborating with engineering, and delivering reliable customer support to drive product impro...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Join a team that's dedicated to delivering innovative structural designs across diverse projects, collaborating closely with project teams to ensure quality and compliance throughout the design and co...

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$81K - $120K *

Empower your career by managing and growing our Syndications platform. Collaborate with internal teams and external partners to structure deals, analyze credit, and enhance portfolio management in a d...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$81K - $120K *

Help us elevate our Syndications platform by managing portfolios, structuring transactions, and collaborating with internal and external partners to drive growth and efficiency in syndicated deals...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $145K *

Unlock potential by leading insights development and storytelling, managing data analysis, and fostering client relationships. Drive project success through collaboration and high-quality deliverables...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$180K - $220K *

Empower our cloud infrastructure by reimagining deployment processes, enhancing security, and driving AI-first development. Collaborate across teams to build robust systems that support our venues and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$95K - $130K *

Join us in leading on-site installation activities for complex projects. As a key liaison, you'll ensure safety, quality, and schedule adherence while coordinating with diverse stakeholders to drive s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$158K - $185K *

Unlock your potential by leading the design and delivery of a transformative Medicaid data platform. Collaborate with stakeholders and guide teams to modernize healthcare systems through innovative cl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $125K *

Lead the charge in diverse control system projects, overseeing tasks and teams while ensuring successful project completion. Collaborate with stakeholders and provide engineering support, driving qual...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Join a dynamic team as a Dynatrace Administrator, optimizing environments and automating incident responses. Leverage your expertise to enhance performance monitoring and ensure seamless integration w...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$128K - $214K *

Empower cross-functional teams to deliver complex technical programs, ensuring alignment with business goals. Lead planning, execution, and stakeholder communication while fostering a collaborative en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Champion a dynamic accounting team, overseeing receivables, payables, and payroll while enhancing internal controls and supporting financial audits. Drive efficiency and accuracy in daily cash managem...

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Drive your career with a pivotal role in strategic sales and account management, focusing on IT cooling solutions. Engage with key customers, develop growth strategies, and lead initiatives that enhan...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$160K - $200K *

Champion innovation as a Senior Software Engineer, driving full-stack solutions and leveraging AI tools to enhance IT lifecycle management. Collaborate with a dynamic team to deliver impactful softwar...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Grow your career in pharmaceutical sales by building relationships in dermatology. This role involves extensive travel to engage with healthcare professionals, promote products, and achieve sales goal...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$122K - $176K *

Lead the charge in evolving a cutting-edge financial assistant, enhancing user experience through innovative features and AI integration while collaborating with cross-functional teams in a dynamic st...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$200K *

Join a team that's dedicated to delivering exceptional eye care solutions while thriving in a dynamic, patient-centered environment. Utilize innovative technology to conduct comprehensive exams and cr...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Lead the charge in executing digital product initiatives for veterinary health. Collaborate across teams to prioritize backlogs, write user stories, and enhance user experiences, ensuring alignment be...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$190K - $238K *

Transform your career by leading the digital strategy for Medical Affairs. Drive innovation, optimize processes, and enhance scientific communications through emerging technologies while collaborating...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$115K - $184K *

Advance HPE's growth in the West by driving strategic initiatives, fostering partner engagement, and enhancing market share within the public sector ecosystem. Collaborate with key stakeholders to cre...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$138K - $200K *

Transform partner success by leading a high-performing team of Channel Managers. Drive growth through innovative strategies, coaching, and collaboration across Microsoft’s ecosystem to achieve measura...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$173K - $234K *

Advance your career by leading a dynamic sales team, driving performance, and fostering relationships with healthcare professionals to enhance patient outcomes through innovative solutions...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$149K - $202K *

Make your mark at the forefront of patient access marketing, leading strategies and initiatives to enhance the Bone portfolio experience. Collaborate cross-functionally to optimize access solutions an...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.