Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$79K - $137K *

Join a team that's shaping the future of reactor physics through innovative computational methods and thermal-hydraulic modeling. Contribute to technical development, regulatory compliance, and custom...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$91K - $152K *

Join a team that's dedicated to managing customer relationships and driving project success in the power generation sector. You'll oversee operations, ensure customer satisfaction, and contribute to s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$92K - $154K *

Join a team that's redefining customer engagement in the energy sector. You'll manage key accounts, develop relationships, and drive sales strategies while collaborating with cross-functional teams to...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$98K - $188K *

Join a team that's shaping the future of reactor physics and technology. Contribute to computational methods development, numerical analysis, and thermal-hydraulic modeling while supporting software d...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$100K - $166K *

Champion project execution and risk management in complex energy infrastructure, driving operational efficiency and digital innovation while collaborating with cross-functional teams to enhance projec...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Champion growth by driving strategic business development in the South-Central Division, focusing on client relationships and sales performance to achieve ambitious revenue targets and enhance market...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$80K - $95K *

Join a team that's dedicated to building strong relationships with personal injury attorneys. Leverage your expertise in settlement planning and wealth management to drive business growth and support...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$72K - $100K *

Engage with independent insurance agencies to drive growth and strengthen relationships. As a key field representative, you'll collaborate with underwriting teams and promote products while managing a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $110K *

Lead a dynamic design team to enhance field installation processes, mentor talent, and implement innovative technologies, ensuring high-quality, efficient delivery of stainless-steel piping systems ac...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Lead the design and development of complex software systems, ensuring architectural consistency and best practices. Collaborate with teams to deliver scalable solutions while mentoring engineers and d...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Join a team that's dedicated to advancing clinical research through statistical expertise. Collaborate with medical professionals to design, analyze, and report on clinical studies, ensuring complianc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$174K - $215K *

Optimize business performance across a hematology/oncology portfolio, focusing on metastatic breast cancer. Develop and execute territory strategies, enhance customer access, and drive results in comm...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$255K - $310K *

Lead a high-performing team to execute market access strategies, optimize payer engagement, and enhance product positioning. Drive collaboration across stakeholders to ensure effective reimbursement a...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$75K - $112K *

Unlock potential by managing complex billing processes and leading a team to ensure accurate invoicing and exceptional customer service. Collaborate across departments to drive efficiency and implemen...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$140K - $160K *

Join a dynamic team as you architect secure CI/CD pipelines, manage Kubernetes clusters, and implement security automation in AWS. Collaborate across teams to enhance operational efficiency while embe...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$320K - $488K *

Partner with us to lead developer relations in quantum computing, driving adoption of innovative SDKs. Collaborate across federal programs as a strategic bridge to elevate scientific research and tech...

RemoteRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$180K - $220K *

Transform global marketing strategies to enhance brand presence and drive demand. Collaborate with cross-functional leaders to align marketing with business goals, fostering growth across diverse mark...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$80K - $95K *

Transform your career by leading comprehensive project estimates and proposals. Leverage your expertise in construction management to evaluate bid specifications, manage subcontractor relationships, a...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Empower project success by leading multi-discipline teams in planning, designing, and managing water and wastewater systems, ensuring quality delivery on time and within budget while fostering strong...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$200K - $500K *

Deliver exceptional user experiences by blending research, design, and collaboration. Drive UX/UI initiatives for web and mobile platforms, ensuring usability and accessibility while aligning with bus...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Optimize site selection and entitlement strategies for data center projects, evaluating land opportunities and coordinating with utilities. Drive feasibility assessments and maintain project schedules...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead the charge in enhancing organizational effectiveness by partnering with leaders to develop talent management strategies, drive change initiatives, and strengthen workforce capabilities across mul...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Partner with us to lead transformative HR initiatives in a dynamic professional services environment. Shape talent strategies, drive AI integration, and build a robust People Services practice that su...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Business Services

$250K - $275K *

Join us to lead clinical operations for a multi-state virtual care team, ensuring high-quality, timely care. This role combines direct patient care, administrative leadership, and strategic oversight...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$88K - $117K *

Join a team that's building robust data infrastructure to transform raw data into actionable insights. This role is vital for developing scalable data models and pipelines, enhancing decision-making a...

1 week ago

  •   Less than 5 years exp.  •   Transportation

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.