Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $130K *

Engage with enterprise clients to drive sales growth through strategic prospecting, relationship building, and consultative solutions. Collaborate with brokers and leverage marketing strategies to exc...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$154K - $221K *

Lead the charge in shaping the sales engineering team for core solutions, driving revenue growth through strategic partnerships and innovative problem-solving in a dynamic environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by leading Agile delivery teams and managing product backlogs. Collaborate with stakeholders to translate business needs into actionable user stories, ensuring alignment with strategi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Lead personnel security programs by directing operations, overseeing adjudications, and managing staff to ensure compliance with federal standards while enhancing the integrity of the Federal workforc...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$70K - $109K *

Champion divisional operations by ensuring adherence to policies, overseeing staff, and enhancing patient services. Collaborate on strategic planning and financial oversight to drive efficiency and qu...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Transform sales performance by collaborating with distributors to enhance market presence and drive growth in the assigned territory. Leverage your expertise in DSD sales to develop local chains and e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$95K - $115K *

Unlock potential by leading a distributor network to drive sales growth, ensuring effective execution of business plans and fostering strong relationships within the marketplace. This role requires st...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$150K - $180K *

Develop and manage scalable AI infrastructure solutions, ensuring secure access to foundation models. Collaborate with cross-functional teams to enhance platform capabilities and drive AI adoption whi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$111K - $207K *

Empower growth by shaping executive talent strategies that drive success. Partner with senior leaders to enhance recruitment processes, develop talent pipelines, and advise on market trends, while ens...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$85K - $90K *

Elevate the future of U.S. Coast Guard acquisitions by managing configuration processes for the Waterways Commerce Cutter. Collaborate with teams to ensure compliance and accuracy in documentation and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$128K - $191K *

Elevate your career by managing utility revenue requirements projects, preparing regulatory filings, and providing expert testimony. Collaborate with clients across North America while leading teams a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$95K - $115K *

Champion IT audit initiatives by leading comprehensive audits, enhancing compliance, and fostering collaboration across departments to mitigate risks and improve operational efficiency...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Join us as a key legal advisor, shaping strategy and guiding executive leadership through complex regulatory and contractual matters while balancing legal risk with business objectives...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$87K - $100K *

Champion the finance operations for Taft-Hartley benefit funds, overseeing reporting, audits, and team development. Drive process improvements and ensure accuracy in financial reporting while liaising...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$94K - $293K *

Drive cybersecurity transformation within Utilities, managing complex engagements, developing tailored strategies, and enhancing operational resilience to safeguard critical infrastructure and meet re...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$108K *

The Registered Nurse (RN) position involves providing direct and indirect patient care in a specialty hospital setting, focusing on chronic, critically ill, and medically complex patients. The role in...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$128K - $213K *

Drive innovative technical solutions in power stability and electrical systems, engaging with customers and collaborating with sales teams to deliver tailored proposals that meet complex requirements...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$100K - $161K *

Advance your career by coordinating clinical trial budgets and coverage analyses. Collaborate with stakeholders to ensure compliance and cost efficiency while mentoring junior staff and enhancing admi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Grow your career with a pivotal role in configuration management, ensuring system stability and compliance. Collaborate across teams to track changes, maintain documentation, and support deployments i...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $96K *

Champion the safety of families by providing tailored home security solutions. Engage directly with customers, guiding them through personalized installations and earning uncapped commissions in a sup...

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$131K - $219K *

Join a team that's redefining cybersecurity in the energy sector. You'll lead complex projects, develop standards, and automate processes to enhance efficiency and security across global Grid Automati...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$155K - $210K *

Drive success by championing patient needs and executing strategic account plans. Leverage clinical expertise and business acumen to exceed sales goals while fostering relationships with key stakehold...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$142K - $237K *

Shape the global quality strategy for Power Sensing and Regulation, ensuring high standards across product lifecycles. Collaborate with cross-functional teams to drive continuous improvement and enhan...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$127K - $212K *

Champion secure architecture by conducting reviews and assessments for cloud and on-premise systems. Leverage your cybersecurity expertise to design solutions that align with security best practices a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$108K - $181K *

Create impactful technical solutions in military electrification projects. Collaborate with defense clients and provide expertise throughout the proposal process, ensuring compliance and mission effec...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.