Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$130K - $170K *

Execute end-to-end digital onboarding of complex AI data center infrastructure, managing cross-functional teams to ensure timely delivery, stability, and optimization of high-performance systems for p...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Innovate solutions in power systems engineering by leading consulting initiatives, enhancing client relationships, and driving strategic growth in protection and control services while ensuring high-q...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$100K - $120K *

Lead the charge in managing clinical operations for dialysis services, ensuring quality patient care, compliance, and operational efficiency across multiple facilities while fostering strong relations...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $150K *

Lead the operations of a Special Investigations Unit, managing a team of investigators to enhance fraud detection and prevention. Drive compliance, collaborate with stakeholders, and shape strategies...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Empower client relationships and drive profitable growth through effective business development and strategic collaboration. Utilize your extensive banking expertise to enhance financial solutions for...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$94K - $126K *

Join a team that's driving growth in military and government sectors by developing strategic sales capabilities and fostering strong customer relationships to maximize territory potential and ensure l...

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$70K - $95K *

Join a dynamic team to empower associates and enhance member experiences. Drive strategic initiatives, foster collaboration, and embrace digital transformation while delivering exceptional results in...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Unlock insights by leading advanced data analytics for federal programs. Collaborate with cross-functional teams to ensure compliance and data integrity while mentoring junior analysts and presenting...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $120K *

Lead EHS initiatives across multiple facilities, ensuring compliance and fostering a safety culture. Drive strategic planning, conduct inspections, and collaborate with teams to enhance environmental...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$200K - $240K *

Advance expertise in energy markets by managing complex client engagements, developing strategic recommendations, and fostering client relationships. Utilize analytical skills to drive impactful solut...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$103K - $181K *

Optimize document control processes by leading the Information Branch, ensuring accurate and accessible records management for a major industrial program while coordinating with various stakeholders a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$88K - $154K *

Optimize document management processes for a large-scale industrial project, ensuring accurate, secure, and accessible records throughout all project phases. Collaborate with multidisciplinary teams t...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Unlock potential by leading a global accounting team, driving process improvements, and integrating AI solutions to enhance financial operations and reporting accuracy in a dynamic SaaS environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Lead the charge in optimizing financial systems, enhancing automation, and improving reporting. Collaborate with Finance and IT to support core processes and drive continuous improvement within establ...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $200K *

Grow your career with a leading RIA by transitioning your client base to a sophisticated platform. Leverage a collaborative team model to deliver comprehensive wealth management solutions for high-net...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $115K *

Lead the charge in implementing the Deacom ERP platform, driving customer success through expert consultation, project management, and tailored solutions. Collaborate with clients to enhance business...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Join a dynamic team as a Senior Sensory Scientist, driving sensory science initiatives across Human Nutrition & Health. Lead studies, train teams, and collaborate with partners to enhance product qual...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$78K - $92K *

Engage in impactful virtual counseling for patients with acute mental health conditions. Develop treatment plans, exercise clinical judgment, and collaborate with multidisciplinary teams to enhance be...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$120K - $130K *

Shape the future of mental health care by providing virtual counseling and developing treatment plans for patients with acute conditions. Collaborate with medical professionals while ensuring adherenc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$125K - $140K *

Drive impactful energy projects by managing schedules, coordinating teams, and analyzing risks. Leverage your expertise in project planning to ensure timely delivery and optimize performance across di...

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$75K - $100K *

Join a dynamic team to drive project success from concept to completion. Collaborate with customers and internal teams to deliver tailored solutions, manage costs, and enhance processes in a fast-pace...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $140K *

Lead the charge in seamless M&A integrations, collaborating across teams to ensure operational continuity, regulatory compliance, and successful transitions while driving strategic initiatives and per...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Transform the accounting function by overseeing monthly closes, ensuring compliance, and managing tax processes. Collaborate with finance leadership to drive accurate reporting and support strategic p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$95K - $100K *

Transform virtual learning by leading strategy and development of innovative programs. Collaborate across teams to enhance educational experiences, ensuring quality and scalability while meeting diver...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$121K - $145K *

Strategize financial operations and enhance reporting accuracy while leading the finance team. Collaborate with senior leadership to drive financial sustainability and operational efficiency across bu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.