Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Senior Principal - AI and Data CRL, Infosys Consulting
$210K - $256K *
Transform industry practices by leading large-scale AI and data initiatives, driving business growth and operational excellence within Consumer Products, Retail, and Logistics sectors...
Reposted 1 week ago
$125K - $225K *
Create innovative data solutions by designing scalable pipelines and AI tools. Collaborate with cross-functional teams to enhance data quality and security, driving impactful analytics and machine lea...
1 week ago
Senior Program Manager/Engineering Manager
$125K - $225K *
Lead the charge in multidisciplinary engineering and design management for a large-scale industrial infrastructure project, ensuring compliance with technical standards and client expectations through...
1 week ago
Account Manager - Beverage and Frozen Dessert Ingredients
$90K - $110K *
Transform the beverage and dessert ingredient landscape by driving sales growth, expanding market presence, and fostering strong customer relationships. Collaborate with cross-functional teams to deli...
1 week ago
Senior Food Application Scientist
$95K - $115K *
Optimize product development in the bakery sector by leveraging scientific expertise to solve complex manufacturing challenges, drive innovation, and support commercialization efforts across diverse m...
1 week ago
$95K - $115K *
Drive innovation in flavor product development, leveraging scientific expertise to tackle complex challenges and support commercialization across food and beverage sectors, while collaborating cross-f...
1 week ago
$73K - $110K *
Champion compliance excellence by managing HR programs, ensuring alignment with laws, and enhancing processes. Collaborate across teams to minimize risk and support organizational growth while navigat...
1 week ago
Senior Program Manager I - RCCA Program Manager
$100K - $120K *
Unlock potential by leading complex subrecipient programs, ensuring compliance, and fostering collaboration across teams to drive impactful opioid response initiatives in Illinois. This role demands s...
1 week ago
Specialty (SBA) Credit Underwriter II/Specialty (SBA) Sr. Credit Underwriter
$91K - $150K *
Empower small businesses by underwriting and approving SBA credit requests. Utilize strong credit skills to analyze financial data, ensure compliance, and collaborate with teams to deliver effective c...
1 week ago
$198K - $233K *
Shape AI product strategy by synthesizing trends, customer needs, and tech capabilities. Collaborate with engineering and design to drive innovation, enabling AI solutions that deliver genuine custome...
1 week ago
$80K - $95K *
Build relationships with personal injury attorneys to drive referrals for settlement planning and wealth management. Leverage your expertise to develop sales strategies and enhance brand awareness whi...
1 week ago
$79K - $127K *
Unlock insights into medical cost trends by leveraging data analytics. Collaborate with cross-functional teams to develop strategic recommendations, track program outcomes, and present findings clearl...
1 week ago
Cyber Risk and Compliance Specialist
$95K - $115K *
Unlock potential by leading IT SOX compliance and enhancing global security culture. Balance technical auditing with advocacy, ensuring financial integrity and regulatory adherence while fostering a r...
Reposted 1 week ago
$183K - $220K *
Lead strategic initiatives for Integrated Delivery Networks and health systems, optimizing patient access and formulary adoption. Build executive relationships and drive clinical integration to enhanc...
1 week ago
Claim Representative III - Property
$77K - $129K *
Lead your career with a pivotal role in technical claim-handling, overseeing investigations and negotiations for complex property claims. Mentor team members and support audits while ensuring complian...
1 week ago
$150K - $180K *
Drive your career as a Compliance Architect, guiding clients through CMMC compliance journeys. Collaborate with stakeholders to assess risks, develop strategic roadmaps, and ensure alignment with regu...
Reposted 1 week ago
$149K - $224K *
Drive analytics excellence by leading a team to deliver impactful insights, enhance reporting capabilities, and support strategic decision-making across diverse business functions. Foster collaboratio...
1 week ago
$135K - $160K *
Join a team that's redefining CRM platforms by architecting innovative, AI-driven solutions. This high-impact role requires visionary leadership to optimize data processing and enhance user experience...
1 week ago
Project Management Director - Energy Advisory | 1898 & Co
$135K - $160K *
Lead the Energy Advisory project management team, driving strategic initiatives and enhancing project delivery across complex engagements while fostering a culture of collaboration and continuous impr...
1 week ago
$162K - $243K *
Lead a dynamic team in managing complex clinical research trials, ensuring project execution aligns with strategic objectives. Drive process improvements and maintain client relationships while overse...
1 week ago
$120K - $145K *
Optimize your skills in developing and maintaining SAS programs within a Mainframe environment. Take charge of code migration to cloud technologies and engage with stakeholders to create analytical so...
Reposted 1 week ago
Director of Revenue Accounting & Assurance
$150K - $180K *
Advance your career by owning revenue accounting and assurance in a dynamic environment. Lead the development of policies, controls, and analytics while ensuring compliance with ASC 606 and preparing...
1 week ago
$150K - $180K *
Join a team that's shaping the future of AI by designing and implementing enterprise-grade solutions on Google Cloud and Azure, focusing on data migration, pipeline development, and robust cloud infra...
1 week ago
Vice President, Brand and Public Relations
$160K - $200K *
Elevate the public relations function by unifying strategy, enhancing agency management, and crafting a compelling enterprise narrative that resonates across regions while delivering measurable busine...
1 week ago
$95K - $115K *
Join a team that's redefining power systems engineering by leading advanced studies in T&D, enhancing software tools, and fostering collaboration across projects to drive innovation and efficiency in...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.