Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $95K *

Engage customers through impactful marketing initiatives that drive retention and growth. Collaborate with Customer Success Managers to create compelling stories, manage events, and amplify the voice...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$104K - $243K *

Join a team that's dedicated to managing commercial banking relationships, focusing on Mortgage Servicing Rights and Warehouse Lending. Drive revenue growth while ensuring compliance and fostering str...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$171K - $383K *

Empower your career by leading innovative data solutions in Life Sciences. Drive customer MDM, data governance, and AI strategies to enhance commercial operations and deliver impactful insights for cl...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$171K - $383K *

Explore innovative solutions in Life Sciences by leading AI-driven customer data strategies. Drive impactful engagements, develop high-performing teams, and shape the future of commercial operations w...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$134K - $265K *

Elevate your career by leading innovative Customer MDM and Data Governance initiatives in Life Sciences. Drive commercial transformation with AI-powered solutions, ensuring accurate data foundations f...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$100K - $145K *

Join a dynamic team to ensure seamless network connectivity for dock deployments. Collaborate with IT teams, troubleshoot connectivity issues, and enhance customer confidence through effective communi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$134K - $265K *

Join a dynamic team to lead innovative Customer MDM and Data Governance solutions in Life Sciences, driving commercial transformation through AI-powered insights and trusted data management for enhanc...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$168K - $285K *

Elevate the future of software planning by leading a team that integrates human and AI collaboration. Shape product direction, connect work to business priorities, and drive strategic decisions in a d...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Join a team that's redefining cloud reliability by enhancing observability, automation, and operational excellence. Collaborate across departments to ensure seamless deployment and management of SaaS...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Join a dynamic team to enhance the reliability and performance of enterprise AI and Sitecore platforms on VMware Cloud. Collaborate with cross-functional teams to deliver secure, scalable solutions th...

1 week ago

  •   15+ years exp.  •   Information Technology

$110K - $130K *

Lead financial operations and strategic insights to enhance scalability and integrity. Oversee accounting functions, reporting, and compliance while partnering with leadership to drive growth and opti...

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$120K - $155K *

Contribute to Oracle database modernization by assessing, planning, and executing migration strategies. Collaborate with technical teams to optimize performance and ensure successful data migration in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Drive data-driven decision-making by transforming complex data into actionable insights. Collaborate with cross-functional teams to enhance reporting and analytics using advanced SQL and AI tools, ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$174K - $215K *

Lead a dynamic team to drive business performance in hematology/oncology, focusing on metastatic breast cancer. Develop strategies for patient access and treatment, ensuring compliance and collaborati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $245K *

Empower the oncology portfolio strategy by driving regional marketing initiatives, fostering KOL relationships, and executing launch tactics to optimize product adoption and customer engagement across...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $160K *

Drive the development of critical enterprise applications for DoD personnel, enhancing program and financial management capabilities. Collaborate within a product team to modernize technology and deli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$162K - $194K *

Drive growth as a Senior Product Marketing Manager, shaping messaging and campaigns for Observability products. Collaborate with cross-functional teams to enhance customer engagement and retention thr...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$122K - $183K *

Transform the aerospace certification landscape by leading process development, ensuring compliance with DO-178C standards, and collaborating with cross-functional teams to deliver high-quality softwa...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Accelerate your career by driving operational excellence and strategic improvements. Collaborate with leadership and cross-functional teams to enhance customer experiences and optimize processes in a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Elevate your career by leading strategic sourcing initiatives, managing vendor relationships, and driving procurement excellence in a dynamic environment focused on innovation and efficiency...

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$75K - $109K *

Advance the future of Building Information Modeling by leading BIM strategies, ensuring model quality, and mentoring teams. Drive innovation through technology initiatives and enhance project delivery...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$85K - $100K *

Champion life underwriting transformation initiatives by analyzing requirements, facilitating project lifecycles, and collaborating with cross-functional teams to enhance operational excellence and im...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Join a dynamic team to design and support advanced Active Network Management Systems, leading their lifecycle from development to commissioning while ensuring integration with external systems and del...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$80K - $100K *

Unlock potential by driving sales growth in a dynamic territory, cultivating relationships with diverse clients, and leveraging technical expertise to deliver effective packaging solutions that surpas...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$210K - $256K *

Transform industry practices by leading large-scale AI and data initiatives, driving business growth and operational excellence within Consumer Products, Retail, and Logistics sectors...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.