Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $130K *

Lead compliance efforts in marketing by ensuring all materials meet legal standards. Collaborate with cross-functional teams to apply guidelines effectively while maintaining a keen attention to detai...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$64K - $109K *

Elevate research efforts by coordinating clinical assessments and participant care in Alzheimer's studies. Collaborate with multidisciplinary teams to ensure protocol adherence and maintain participan...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$190K - $210K *

Collaborate with cross-functional teams to drive clinical biomarker strategy and execution, translating discovery insights into actionable approaches that enhance patient outcomes in early neuroscienc...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$68K - $123K *

Coordinate care for patients with rare neurologic disorders, fostering relationships and ensuring continuity across multidisciplinary teams. Engage families, manage care plans, and support educational...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Take ownership of payroll operations, ensuring accuracy and compliance while leading a team to deliver timely wage payments and manage tax obligations effectively across the organization...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$116K - $229K *

Drive innovation in Life Sciences by leveraging AI and data analytics to transform commercial operations. Collaborate with high-performing teams to deliver impactful solutions that enhance client enga...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$100K - $187K *

Grow your career with an Associate Engagement Manager role, leading client relationships and driving business development within the Telecom vertical, managing accounts worth $10M-$30M, and ensuring d...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$145K - $180K *

Transform retail operations by serving as the primary SAP POS expert for DoD S/4HANA implementations, ensuring alignment with operational goals and financial reporting while bridging technical teams a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $185K *

Unlock your potential as a Project Director, leading innovative health research initiatives. Drive strategic planning and capture opportunities while managing a dynamic team to tackle complex public h...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$63K - $111K *

Empower mission success by assessing utility vulnerabilities and enhancing infrastructure resilience against diverse threats. Collaborate with a multidisciplinary team to ensure operational continuity...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$155K - $170K *

Join us to lead healthcare data and cloud transformation initiatives, guiding organizations through modernization efforts. Leverage your expertise in cloud architecture and data analytics to drive str...

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $250K *

Transform financial services by leading complex banking operations and technology projects. Collaborate with clients to enhance performance, drive innovation, and shape a new practice within a dynamic...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$137K - $245K *

Shape the future of physical operations by driving AI-powered product innovation. Collaborate across teams to identify customer needs, prototype solutions, and deliver impactful products that enhance...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Shape the future of healthcare by leading complex implementations across provider and payor organizations. Drive project success through collaboration, strategic planning, and innovative solutions whi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$102K - $184K *

Elevate your career by leading market-level financial reporting and performance management in value-based healthcare. Collaborate with stakeholders to drive insights and outcomes, ensuring disciplined...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Champion innovative civil engineering solutions for transmission and substation projects. Collaborate with teams to design, plan, and enhance critical infrastructure, ensuring safety and reliability i...

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Transform customer success strategies to enhance client satisfaction and retention. Lead a dynamic team, driving initiatives that elevate user experience and foster growth within a fast-paced SaaS env...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$110K - $130K *

Unlock potential by joining a dynamic Clinical Oncology Team, where you'll leverage your oncology and genomics expertise to enhance point-of-care products, drive clinical workflows, and support person...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Accelerate progress at a dynamic engineering team, tackling complex technical challenges while delivering high-quality code. Own architectural decisions and enhance integration across services in a co...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$77K - $202K *

Elevate client success by optimizing ERP transformations through analysis, implementation, and training. As a Senior Associate, you'll manage workstreams, mentor junior members, and build strong clien...

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$77K - $202K *

Join as a Senior Associate to optimize ERP transformations, analyze client needs, manage workstreams, and mentor junior team members while delivering value through agile methodologies and technology s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$110K - $130K *

Transform client relationships by leading a dynamic team to achieve financial growth and enhance client experiences across a diverse portfolio. Drive strategic initiatives and foster collaboration to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $180K *

Transform quality management across renewable energy projects by leading initiatives that enhance processes, ensure compliance, and drive continuous improvement. Collaborate with cross-functional team...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$160K - $190K *

Transform security solutions across multiple domains, driving technical direction and collaboration to address high-risk items and enhance Meta's security posture company-wide. Lead cross-functional t...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $100K *

Join our dynamic team as a Technical Delivery Manager, overseeing AI-driven project delivery across diverse digital platforms. Ensure timely, high-quality outputs while leveraging innovative technolog...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.