Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
21GRAMS- Director, Product Design
$140K - $155K *
Empower teams to elevate product design through strategic vision, fostering collaboration across disciplines to create impactful digital experiences that meet user needs and business goals while ensur...
1 week ago
$123K - $158K *
Unlock your potential by driving enterprise sales growth across the Americas. Collaborate with cross-functional teams to manage the full sales cycle, from prospecting to closing, while building strong...
1 week ago
Mid-Market Account Executive, Networks
$142K - $215K *
Elevate your career by driving new business growth in a dynamic sales environment. Own the full sales cycle, collaborate with teams, and exceed revenue goals while engaging with key stakeholders in a...
1 week ago
$68K - $102K *
Join a team that's dedicated to delivering exceptional field service solutions. Collaborate with customers and partners to perform assembly, diagnostics, and maintenance on critical power equipment in...
1 week ago
Customer Success Manager (US Remote)
$100K - $120K *
Join a team that champions customer success by driving strategic relationships, ensuring retention, and enhancing business value for clients through proactive engagement and effective program manageme...
Reposted 1 week ago
Strategic Account Executive - AI, San Francisco
$124K - $186K *
Empower enterprise growth by driving strategic account management for AI-native companies, guiding complex transformations, and fostering long-term partnerships through innovative DevSecOps solutions...
1 week ago
Group Product Management Manager
$236K - $296K *
Lead innovative product initiatives by owning vision, strategy, and execution. Collaborate with cross-functional teams to transform ideas into scalable solutions, driving impactful outcomes for the co...
1 week ago
$85K - $130K *
Empower customer success by leveraging technical expertise and business acumen. Build relationships, optimize implementations, and enhance support experiences while collaborating with internal teams t...
1 week ago
Technical Product Owner – Data Products
$110K - $130K *
Join a dynamic team to bridge product strategy and engineering delivery, transforming data into actionable insights for innovative financial solutions. Collaborate with cross-functional teams to drive...
Reposted 1 week ago
$80K - $95K *
Accelerate progress at the forefront of scientific sales by driving growth across diverse markets. Leverage your expertise to build relationships and solve complex challenges while managing the full s...
1 week ago
$173K - $198K *
Lead the evolution of data architecture, driving real-time capabilities and AI integration. Collaborate with executives and teams to enhance data quality, governance, and scalability while mentoring a...
1 week ago
$120K - $140K *
Lead the charge in implementing and maintaining ISO 27001:2022 compliance, driving cross-functional initiatives, and enhancing the Information Security Management System while collaborating with diver...
1 week ago
Data Center Operations System Engineer - Plano, TX
$100K - $120K *
Collaborate with cross-functional teams to ensure optimal data center operations, managing infrastructure setup, troubleshooting, and documentation while maintaining high standards for deployment and...
1 week ago
$122K - $176K *
Drive impactful threat intelligence by synthesizing complex data into actionable insights. Collaborate across teams to create tailored intelligence products that enhance security understanding and sup...
1 week ago
$128K - $250K *
Champion the development of winning strategies for complex public sector opportunities, engaging directly with customers and stakeholders to shape solutions and lead major pursuits from identification...
1 week ago
$118K - $174K *
Drive successful project outcomes by leading cross-functional teams and managing large-scale ERP and SAP projects. Collaborate with stakeholders to align on objectives and implement effective change s...
Reposted 1 week ago
$80K - $95K *
Transform the Funding Department by leading a dedicated team, ensuring compliance with policies, optimizing processes, and fostering professional development to achieve high-quality funding approvals...
1 week ago
$100K - $120K *
Empower healthcare organizations by driving sales of innovative Nurse Call solutions. Own the full sales cycle, engage with senior leaders, and leverage your expertise to navigate complex deals in a d...
1 week ago
Platform Engineer (ServiceNow)
$110K - $130K *
Pioneer the administration and development of core business systems, focusing on ServiceNow. Collaborate with cross-functional teams to create scalable solutions that enhance operations, service, and...
Reposted 1 week ago
$95K - $115K *
Accelerate progress at the intersection of marketing and data analytics. As a key player, you'll build reporting functions, define KPIs, and drive insights that empower teams across the organization t...
1 week ago
Global Scientific Evidence Manager, Restorative Procedures
$143K - $196K *
Lead global evidence strategy and drive scientific engagement while collaborating cross-functionally to identify evidence gaps and shape priorities in clinical, R&D, and marketing teams. Make a signif...
1 week ago
$95K - $115K *
Join a team that's dedicated to delivering innovative design-build projects, managing all phases from conception to closeout, and ensuring successful execution of multimillion-dollar initiatives acros...
1 week ago
$100K - $120K *
Transform the marketing landscape by leading growth initiatives, building campaigns, and leveraging data to drive qualified pipeline. Collaborate with cross-functional teams to activate strategies and...
1 week ago
Director, Commercial CMC Programs
$150K - $180K *
Empower the execution of CMC strategies by collaborating across teams to enhance production, streamline operations, and drive commercial success for innovative therapeutics and diagnostics, ensuring a...
Reposted 1 week ago
$150K - $200K *
Unlock potential by defining and guiding enterprise architecture, integrating cloud, infrastructure, and security to support business priorities. Lead modernization efforts and influence cross-functio...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.