Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$125K - $135K *

Lead the strategic planning and execution of complex programs across multiple teams, ensuring alignment with business priorities and effective risk management. Drive delivery improvements and maintain...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$88K - $105K *

Join our team to oversee project management, ensuring quality, budget adherence, and timely delivery. You'll lead subcontractors, manage estimates, and maintain client relationships while driving proj...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$200K - $250K *

Accelerate your career by driving sales growth in capital equipment and medical instruments. Build relationships with key stakeholders, manage sales funnels, and provide technical support to enhance c...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Shape employee relations and compliance strategies while leading investigations, managing performance improvement, and ensuring adherence to labor laws across multiple locations...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Unlock potential by leading strategic sales initiatives to drive revenue growth, enhance client relationships, and expand market share in the hospitality sector. Collaborate with teams to optimize per...

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$80K - $95K *

Drive growth by managing client relationships and selling innovative solutions in the commercial real estate sector. Leverage your expertise throughout the sales cycle to exceed targets and enhance cl...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Transform revenue operations by owning the bottoms-up revenue model, partnering with leadership to drive strategic planning and analysis, and ensuring alignment with growth targets in a dynamic, high...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$160K - $192K *

Join us to drive commercial performance by engaging healthcare providers, building relationships, and supporting product launches. Collaborate with cross-functional teams to ensure patient access to i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Transform go-to-market strategies by executing industry-focused marketing initiatives, driving collaboration across teams to enhance growth initiatives with tailored messaging and customer insights, f...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$148K - $263K *

Architect high-performance OneStream solutions by translating complex requirements into scalable designs. Lead a team of consultants, ensuring technical quality and optimizing integrations while excee...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Accelerate progress at the forefront of project management by leading complex programs, performing programmatic analysis, facilitating funding coordination, and ensuring execution excellence in collab...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$102K - $140K *

Shape the future of customer success by leading implementation strategies, fostering cross-functional partnerships, and driving scalable processes for new customer rollouts in a dynamic B2B SaaS envir...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock potential by leading a high-performing broker network to optimize revenue growth and enhance conversion success through strategic data analytics and collaboration...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$126K - $150K *

Champion growth strategies for net-new business, driving critical sales across cyber threat intelligence. Influence Fortune 1000 leaders in high-stakes environments while navigating complex sales cycl...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Engage with cross-functional teams to drive clinical trial success across regions. Leverage your expertise in project management and mentoring to ensure compliance, quality, and timely execution of st...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Unlock your potential as a Senior Full Stack Software Engineer, leading impactful projects and shaping technology solutions. Collaborate across web applications, backend services, and cloud infrastruc...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Lead the charge in AI innovation within our Insurance portfolio, overseeing the full lifecycle of solutions from ideation to production. Shape strategy, manage multidisciplinary teams, and build new c...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$79K - $139K *

Join a team that's dedicated to driving excellence in clinical trial contracts. As a Senior Site Contracts Manager, you'll negotiate and manage site budgets and agreements, collaborating with key stak...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Advance your career by leading medical writing projects in a regulatory environment. Collaborate with cross-functional teams to produce high-quality documents, ensuring compliance with industry standa...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Partner with us to drive transformative healthcare solutions by managing key accounts, fostering relationships, and ensuring measurable outcomes. Your expertise will enhance provider partnerships and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$200K - $250K *

Empower patient care by joining a dedicated dental team focused on providing quality services to adults and children. Enjoy a supportive environment with flexible hours and competitive compensation, f...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive Beam's growth by securing partnerships and expanding market presence. Lead the sales cycle for Beam Notes, engaging key sectors and refining strategies to enhance product-market fit in the US. Y...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$97K - $113K *

Join a team that's dedicated to maintaining and enhancing rail facilities, overseeing maintenance operations, and ensuring safety standards while managing a diverse workforce and supporting capital pr...

1 week ago

  •   Less than 5 years exp.  •   Transportation

$160K - $200K *

Transform security architecture by defining standards, leading reviews, and managing risks. Collaborate with teams to ensure secure, efficient integration of applications and AI, while maintaining cle...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$76K - $93K *

Unlock potential by leading prospect research and development efforts to enhance fundraising strategies. Collaborate across teams to optimize pipelines, improve data practices, and drive revenue growt...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.