Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$120K - $145K *

Join a team that's transforming medicine by engaging with KOLs and healthcare professionals. Leverage your clinical expertise to communicate product benefits, support education, and drive strategic in...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a dynamic legal team to manage contracts, compliance, and governance. Collaborate with leadership to enhance legal processes and mitigate risks in a fast-paced environment, making a significant i...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$86K - $138K *

Champion the seamless member experience in healthcare access by defining product strategy and overseeing execution. Drive innovation in finding and scheduling care, ensuring accuracy and satisfaction...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $180K *

Transform digital services by collaborating on Azure cloud engineering, CI/CD, and observability. Support mission-aligned platform capabilities while ensuring secure, reliable, and maintainable soluti...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$88K - $105K *

Tackle the challenges of electronics development and remanufacturing by leading assessments and engineering analysis for diverse electronic devices, enhancing product viability and quality while colla...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$140K - $180K *

Unlock potential by leading digital transformation initiatives, leveraging open source and cloud technologies. Collaborate with cross-functional teams to enhance public sector solutions, ensuring clar...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$107K - $209K *

Drive profitable growth by managing territory relationships, underwriting, and operational initiatives. Collaborate with teams to enhance sales strategies and customer service standards while ensuring...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Develop and enhance core infrastructure platforms, ensuring operational excellence and security. Collaborate with cross-functional teams to maintain reliable services, support disaster recovery, and d...

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$80K - $95K *

Join a dynamic team to enhance and secure core infrastructure platforms, focusing on virtualization, cloud services, and disaster recovery. Collaborate with cross-functional teams to ensure operationa...

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$85K - $120K *

Drive excellence in network operations by providing 24/7 support, designing solutions, and ensuring compliance with security best practices. Collaborate with teams to enhance customer connectivity and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$122K - $317K *

Drive large-scale tech transformations by advising senior executives on infrastructure strategies, leading engineering programs, and shaping modern, resilient infrastructure across diverse environment...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Business Services

$190K - $267K *

Shape the future of app advertising by enhancing backend systems for conversion signals. Drive MMP integrations, SKAN processing, and App CAPI to ensure reliable app installs and in-app events for adv...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$194K - $228K *

Lead the charge in sustainability as a senior executive, driving growth and innovation in occupier facilities management. Mentor teams, enhance client relationships, and spearhead strategic initiative...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$160K - $192K *

Drive commercial success by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and enhance patient access to innovative th...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$88K - $154K *

Optimize and integrate the manufacturing process for hazardous materials, taking ownership from design through commissioning. Collaborate with multidisciplinary teams to ensure safety and efficiency i...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$160K - $187K *

Transform the Time & Attendance engineering team by leading technical delivery, fostering collaboration, and driving platform modernization to enhance healthcare workforce solutions and ensure data ac...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$124K - $158K *

Drive the charge in transforming patient care by leading pharmacy operations, ensuring safe dispensing, and fostering a culture of excellence while supporting team development and patient health outco...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$98K - $163K *

Champion transformative financial management solutions by optimizing processes, enhancing efficiency, and implementing intelligent automation. Collaborate with clients and teams to drive impactful cha...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$119K - $190K *

Drive your career forward by leading market expansion for our Grid Automation portfolio. Engage utility customers and partners, develop innovative solutions, and influence industry standards to propel...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Transform the Tool Room operations by leading design, fabrication, and maintenance of stamping dies. Oversee a skilled team, drive process optimization, and ensure adherence to quality standards while...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$115K - $201K *

Join a dynamic team as you oversee client relationships and manage workflows in Private Markets. Lead a talented staff while ensuring compliance and delivering accurate financial reporting for diverse...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Unlock potential by delivering impactful leadership and soft skills training for pharmaceutical and life sciences professionals. Engage diverse audiences, foster collaboration, and drive behavior chan...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Transform enterprise applications as a key contributor in Java and Angular development, driving agile innovations in property and casualty insurance solutions for optimized performance and stakeholder...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Join a team that's dedicated to leading and enhancing Casualty claims operations. Oversee daily activities, provide coaching, and ensure compliance while fostering a culture of excellence in customer...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.