Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$114K - $167K *

Lead the charge in optimizing ERP solutions by analyzing complex business processes, designing customizations, and implementing integration workflows to enhance performance and compliance across vario...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$106K - $167K *

Join a team that's redefining ERP solutions by analyzing complex business processes, developing custom architectures, and leading data migrations to optimize performance and compliance across diverse...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$107K - $144K *

Lead and execute comprehensive quality assurance for Workday implementations, ensuring alignment with business needs and high-quality outcomes. Oversee testing strategies, manage defect lifecycles, an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$80K - $105K *

Engage in frontline cyber investigations to safeguard AI systems from malicious threats. Analyze flagged telemetry, evaluate cyber prompts, and enhance automated safety classifiers while collaborating...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$78K - $120K *

Drive the optimization of our Salesforce platform, ensuring user support and seamless configuration management. Collaborate to implement solutions and enhance security protocols while staying current...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Bring your expertise to drive revenue growth in healthcare through consultative sales and strategic partnerships. Own the full sales cycle, collaborate cross-functionally, and mentor future hires in a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $165K *

Empower clients by leveraging technical expertise to demonstrate product value, cultivate relationships, and drive sales success through effective communication and strategic engagement with stakehold...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Engineer robust integrations between diverse DMP platforms, enhancing productivity through API development, coding best practices, and debugging across multiple programming languages while ensuring ti...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$71K - $106K *

Shape the future of emergency care as a Charge Nurse, leading a team in patient throughput coordination. Engage in high-impact clinical support while upholding patient safety and quality standards in...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Drive the strategic vision for Technical Support, enhancing service delivery and operational efficiency while championing AI transformation and innovation to elevate customer experience and achieve bu...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$120K - $150K *

Lead the strategic alignment of R&D and IT, ensuring compliance and scalability of Veeva systems. Drive technology roadmaps, manage vendor relationships, and mentor junior partners while enhancing reg...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$77K - $102K *

Lead the charge in delivering innovative civil engineering solutions for large-scale data center projects. Collaborate with multidisciplinary teams while developing your skills and expertise in a supp...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$200K - $275K *

Lead the development of off-board AI evaluation frameworks to optimize safety and performance for autonomous vehicles. Collaborate with cross-functional teams to design scalable systems and enhance di...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Transportation

$110K - $130K *

Unlock your potential by driving sales of innovative pulmonary solutions. Collaborate with diverse stakeholders to enhance patient care and achieve sales targets in a dynamic healthcare environment. J...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Analyze complex model development and validation projects, leveraging your statistical expertise to drive performance management. Collaborate with senior managers and progress to a subject matter expe...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Champion complex model development and validation across diverse projects. Leverage your statistical expertise to enhance performance management while collaborating with senior leaders and progressing...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$229K - $310K *

Drive project management and business development to enhance operational efficiency in life sciences R&D, while leading diverse teams and ensuring profitability through strategic customer engagement a...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Transform enterprise learning by leading a team to design impactful solutions. Drive employee development, align training with business goals, and optimize learning technologies for enhanced performan...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Unlock the potential of technology in rural development by leading strategic IT initiatives, ensuring compliance with security standards, and fostering collaboration across divisions to enhance enterp...

1 week ago

  •   5 - 7 years exp.  •   Transportation

$110K - $130K *

Drive strategic leadership in IT security and application development, overseeing risk management and ensuring compliance with policies. Collaborate with executives to enhance technology systems and f...

1 week ago

  •   5 - 7 years exp.  •   Transportation

$100K - $115K *

Empower our sales and marketing initiatives across multiple states, driving occupancy and revenue goals through strategic planning, data analysis, and collaboration with agency teams to enhance patien...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Unlock potential by leading strategic initiatives in supply chain management for submarine production, focusing on risk identification, supplier engagement, and innovative solutions to enhance industr...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Business Services

$210K - $250K *

Join a team that's redefining patient care with innovative hybrid shifts. Your role will integrate daytime and nighttime responsibilities within a supportive environment, ensuring work-life balance wh...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$320K - $400K *

Join a team that's dedicated to advanced cardiac and thoracic surgery, offering diverse cases and collaborative practice within a supportive, academic community that values excellence and patient care...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Transform your career by leading nursing teams in delivering exceptional ambulatory care. Oversee clinical practices, ensure quality standards, and foster collaboration to enhance patient outcomes and...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.