Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$136K - $182K *

Redefine commercial pricing strategies by leveraging advanced actuarial analysis, supporting portfolio-level assessments, and mentoring junior colleagues within a dynamic, remote team of professionals...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$64K - $99K *

Lead the charge in overseeing complex clinical research studies, providing mentorship and direction to multidisciplinary teams while ensuring ethical standards and research integrity are upheld throug...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $218K *

Unlock your potential by delivering data-driven solutions for upstream oil and gas operations. Collaborate with experts to enhance analytics and AI capabilities, driving informed decisions across expl...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$110K - $218K *

Help us advance upstream oil and gas operations by building data-driven AI solutions. Collaborate with experts to enhance decision-making through innovative data engineering and analytics, contributin...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$95K - $115K *

Lead strategic portfolio development and profitable growth in construction casualty underwriting, leveraging industry expertise to manage complex risks and build strong broker relationships across the...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$88K - $105K *

Drive aerodynamic testing initiatives by planning, executing, and analyzing complex wind tunnel tests. Collaborate with multidisciplinary teams to ensure data integrity and safety while developing inn...

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$75K - $135K *

Unlock the potential of secure application access by providing engineering support, troubleshooting connectivity issues, and collaborating with teams to enhance service reliability and customer experi...

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1 week ago

  •   Less than 5 years exp.  •   Healthcare

$215K - $408K *

Join a dynamic team to lead medical management and quality improvement initiatives, ensuring optimal care delivery and cost-effectiveness while collaborating with clinical teams and providers to enhan...

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1 week ago

  •   Less than 5 years exp.  •   Healthcare

$200K - $225K *

Lead the charge in optimizing property tax strategies across North America, ensuring compliance and minimizing liabilities. Collaborate cross-functionally to drive impactful decisions and enhance tax...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a team that's shaping the future of aftermarket solutions by driving growth through strategic customer engagement and innovative lifecycle management. Collaborate cross-functionally to enhance pr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$73K - $100K *

Elevate workforce planning by transforming data into impactful insights. Partner with leaders to build strategic forecasting tools and measure performance metrics, contributing to operational efficien...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $110K *

Champion growth by developing strategic partnerships in international airfreight. Drive profitable expansion through client engagement, leveraging expertise in logistics solutions to enhance market pr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$79K - $83K *

Help us advance hearing solutions by providing clinical and sales support across North and Central Virginia. Join a dedicated team and develop expertise in cochlear implants while building strong cust...

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1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Elevate your career with a dynamic team focused on innovative accounting solutions. Lead financial processes, ensure compliance, and drive efficiency in a fast-paced environment while collaborating cr...

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1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Elevate your career by managing a dynamic team, ensuring exceptional service delivery, and fostering employee development while driving customer satisfaction across diverse sectors...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$108K - $250K *

Join a dynamic team to enhance patient care by promoting innovative oncology solutions, educating healthcare providers, and driving strategic account management to elevate brand presence and improve p...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$176K - $294K *

Engage with healthcare professionals to deliver medical expertise and insights in oncology. Drive strategic initiatives, foster collaboration, and enhance patient-centric communications across diverse...

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Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$124K - $207K *

Advance laboratory design and space planning by translating R&D needs into innovative, flexible environments. Collaborate with stakeholders to optimize safety, efficiency, and sustainability across gl...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$76K - $199K *

Empower your career by driving sales and building relationships in the healthcare sector. Engage with customers through innovative strategies, leveraging your expertise to promote breakthrough therapi...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$108K - $250K *

Champion the promotion of innovative oncology solutions, enhancing patient care through strategic partnerships with healthcare providers and key opinion leaders, while driving brand growth and deliver...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$230K - $384K *

Shape the future of oncology by leading medical strategy and engagement across diverse customer segments. Collaborate with internal teams to deliver impactful medical insights and support clinical ini...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$131K - $200K *

Join a team that's shaping the future of data platforms by developing scalable solutions for analytics and AI workloads. Collaborate on impactful projects using cutting-edge tools to enhance data reli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$73K - $115K *

Grow your career with a dynamic team focused on optimizing provider operations. Lead credentialing initiatives, implement AI solutions, and enhance workflows while ensuring compliance and operational...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $115K *

Help us drive operational excellence in provider data management, ensuring accuracy and efficiency throughout the lifecycle. Collaborate with teams to enhance processes, leverage insights, and impleme...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$58K - $105K *

Unlock your potential by managing the full contracting lifecycle, supporting critical agreements for Medicare Advantage and Commercial operations, while collaborating with diverse teams to enhance com...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.