Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$227K - $335K *

Empower growth through strategic marketing leadership, leveraging data insights to drive customer engagement and revenue. Build and mentor a high-performing team to transform analytics into actionable...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Transportation

$155K - $259K *

Transform healthcare performance by leading integrated optimization programs that enhance clinical, operational, and financial outcomes for hospitals and health systems. Drive measurable results throu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$135K - $160K *

Optimize our IT operations and GRC framework, ensuring seamless integration while managing compliance and security practices. Lead teams, drive audit readiness, and build a resilient infrastructure to...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Shape the future of product design by transforming concepts into high-fidelity experiences. Collaborate with cross-functional teams to enhance user interactions through innovative prototyping and AI-a...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Join a team that's driving growth in the biopharmaceutical sector by developing strategic business relationships, prospecting new clients, and leading sales initiatives to achieve organizational objec...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$88K - $105K *

Grow your career with a dynamic role focused on strategic marketing initiatives, client engagement, and brand management within the Federal sector. Lead multi-channel programs and drive measurable res...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$80K - $95K *

Unlock potential by leading strategic sourcing initiatives that optimize supply chains, reduce costs, and enhance sustainability. Drive vendor relationships and compliance while leveraging analytical...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Unlock potential by providing vital support for US cotton trading operations. Manage CCC loan processes, coordinate transactions, and ensure compliance while enhancing trading strategies to maximize i...

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$80K - $95K *

Optimize trading support operations by managing cotton transactions, ensuring compliance, and enhancing inventory strategies to maximize commercial performance and operational efficiency...

Chesterfield, MORemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$95K - $110K *

Empower businesses by providing tailored HR solutions, leveraging your consultative sales skills to build lasting relationships and drive growth in a supportive, dynamic environment focused on client...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$135K - $145K *

Partner with us to elevate healthcare communications by crafting compelling copy for HCP campaigns. Lead creative initiatives, collaborate with cross-functional teams, and ensure brand consistency acr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$163K - $203K *

Shape the future of defense infrastructure by leading technical engagements and ensuring successful project execution. Collaborate with stakeholders to deliver innovative solutions that meet mission-c...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$80K - $95K *

Grow your career with a dynamic team focused on promoting healthcare products. Engage with healthcare providers, execute strategic plans, and leverage data to drive sales performance while building la...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$84K - $124K *

Join us to lead the acquisition and management of right of way agreements for fiber optic projects across North America, collaborating with stakeholders to ensure compliance and successful negotiation...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$110K - $130K *

Lead the charge in driving revenue growth by cultivating federal civilian sales opportunities. Collaborate cross-functionally to execute strategic initiatives and establish key relationships, ensuring...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$93K - $191K *

Manage strategic federal contract administration activities, advising on contract strategy and execution. Lead negotiations and coordinate with stakeholders to ensure compliance and optimize performan...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$93K - $191K *

Transform federal contract management by leading strategic initiatives, ensuring compliance, and driving negotiations across complex engagements to enhance revenue retention and operational success...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$100K - $120K *

Lead procurement initiatives by providing expert acquisition support to enhance operational efficiency and compliance within federal programs, ensuring successful project execution and stakeholder col...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$102K - $190K *

Pioneer the future of endpoint security by leading a dynamic engineering team, ensuring operational excellence, and driving innovative capabilities to protect enterprise assets while aligning with bus...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $160K *

Join a team that's redefining data solutions by leading technical sales efforts, collaborating with Account Managers, and driving customer success through innovative data architecture and tailored dem...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$126K - $164K *

Pioneer innovative solar designs for utility-scale projects, leading teams to optimize high-level concepts into actionable plans. Engage with clients and ensure quality standards while contributing to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$90K - $150K *

Join us in enhancing employee skills and knowledge through innovative training strategies. Lead a dedicated team to drive operational efficiency and foster a culture of continuous learning that attrac...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$184K - $230K *

Lead the charge in transforming business readiness and deployment excellence across the Americas, ensuring seamless Oracle E-Business Suite upgrades while aligning regional priorities with global stra...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$111K - $167K *

Transform financial operations by driving monthly close processes, managing forecasts, and leveraging AI for process improvements while serving as a key business partner to leadership to enhance strat...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $190K *

Transform your career with a pivotal role in supply chain management, overseeing procurement and execution of critical systems for global data center projects, ensuring quality and timely delivery whi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.