Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $150K *

Lead the charge in enhancing sales performance through targeted enablement initiatives. You'll work closely with diverse sales teams to coach, train, and build effective tools, ensuring impactful and...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$102K - $190K *

Lead the charge in managing firewall infrastructure engineering, ensuring operational excellence, scalability, and security. Drive team performance, oversee lifecycle management, and enhance capabilit...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$82K - $150K *

Accelerate growth by driving new customer acquisition and expanding market share in the dental implant sector. Leverage a hunter mentality to convert competitive accounts and position value-oriented s...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $220K *

Oversee a specialized team to ensure AI safety in biological research, addressing dual-use risks and providing expert guidance on complex cases while mentoring junior specialists and advising clients...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$82K - $114K *

Join a team that's driving innovation in digital and automation projects, ensuring compliance and standardization across capital initiatives in manufacturing environments. Collaborate with stakeholder...

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$90K - $105K *

Elevate your career by leading administrative functions and strategic initiatives. Collaborate with senior management to enhance operations, oversee diverse teams, and drive impactful policies within...

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$117K - $150K *

Champion your actuarial expertise to drive financial reporting and reserve setting for annuities. Collaborate on high-impact projects, adapt to evolving needs, and enhance reporting models in a dynami...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Lead strategic initiatives by managing complex projects from inception to launch. Collaborate across teams to implement new markets and contracts, ensuring compliance and operational readiness in a dy...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Advance business growth by building strategic relationships and identifying client needs. Drive sales initiatives and ensure seamless implementation of client programs while meeting profit margins and...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Manage and enhance enterprise applications, leading a team to ensure optimal performance, support, and user satisfaction while collaborating with IT and vendors to drive improvements and maintain docu...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$100K - $120K *

Manage and enhance enterprise applications, leading a team to ensure optimal performance, support, and user satisfaction while collaborating with IT and vendors to drive improvements and maintain docu...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Lead the charge in project management excellence, overseeing a dynamic team to ensure financial performance and client satisfaction across a diverse portfolio of construction projects. Drive continuou...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Optimize backend systems for a financial platform, integrating AI features and ensuring reliability across multiple regions. Collaborate with global teams to enhance product capabilities and maintain...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Shape the future of materials management by leading a cohesive team. Ensure material availability, optimize inventory, and drive supplier performance to meet production needs. Engage in continuous imp...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Engineer and develop functional tests for embedded firmware in advanced metering infrastructure. Collaborate with a team to ensure quality and compliance in electronic systems, contributing to innovat...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Reimagine automated systems by leading a talented team of technicians to enhance equipment reliability, safety, and productivity through effective maintenance, troubleshooting, and continuous improvem...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$140K - $223K *

Unlock potential by leading human-centered design efforts in clinical settings, translating user insights into AI-enabled solutions that enhance patient care and clinician efficiency within a collabor...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $150K *

Engage as a key Contract Manager, overseeing procurement agreements and providing strategic guidance across teams. Collaborate on complex projects, ensuring compliance and effective negotiation while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$100K - $160K *

Lead critical evaluations of biological risks, mentor junior specialists, and ensure high-quality labeling for AI safety classifiers in a dynamic life-sciences environment focused on biodefense and bi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$160K - $229K *

Transform client experiences by leading SAP CX solutions, ensuring seamless integration and delivery from discovery to go-live while collaborating with cross-functional teams to drive business success...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$109K - $144K *

Join a dynamic team to drive operational excellence and process improvements in healthcare. Lead complex initiatives, influence strategy, and enhance care delivery while collaborating across multiple...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$133K - $173K *

Unlock potential by leading the commissioning of hyperscale data centers. Manage project lifecycles, coordinate teams, and ensure compliance with client requirements while fostering strong stakeholder...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$150K - $180K *

Manage and coordinate patient scheduling and inventory control while enhancing operational efficiency. Collaborate across departments to develop business strategies, oversee budgets, and maintain comp...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$123K - $135K *

Engage with existing customer accounts to drive renewal retention and expansion revenue. Collaborate with cross-functional teams to identify growth opportunities and ensure customer satisfaction while...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$200K - $210K *

Champion innovative content strategies to transform editorial operations, enhance audience engagement, and establish a trusted resource for leaders in government and education. Drive organizational ch...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.