Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Sales Enablement Program Manager
$110K - $150K *
Lead the charge in enhancing sales performance through targeted enablement initiatives. You'll work closely with diverse sales teams to coach, train, and build effective tools, ensuring impactful and...
Reposted 1 week ago
Manager, Firewall Infrastructure Engineering
$102K - $190K *
Lead the charge in managing firewall infrastructure engineering, ensuring operational excellence, scalability, and security. Drive team performance, oversee lifecycle management, and enhance capabilit...
1 week ago
Territory Sales Representative, Implants MIS
$82K - $150K *
Accelerate growth by driving new customer acquisition and expanding market share in the dental implant sector. Leverage a hunter mentality to convert competitive accounts and position value-oriented s...
Reposted 1 week ago
$150K - $220K *
Oversee a specialized team to ensure AI safety in biological research, addressing dual-use risks and providing expert guidance on complex cases while mentoring junior specialists and advising clients...
1 week ago
Digital and Automation Project Engineer
$82K - $114K *
Join a team that's driving innovation in digital and automation projects, ensuring compliance and standardization across capital initiatives in manufacturing environments. Collaborate with stakeholder...
1 week ago
Director of Administration AD041126
$90K - $105K *
Elevate your career by leading administrative functions and strategic initiatives. Collaborate with senior management to enhance operations, oversee diverse teams, and drive impactful policies within...
1 week ago
$117K - $150K *
Champion your actuarial expertise to drive financial reporting and reserve setting for annuities. Collaborate on high-impact projects, adapt to evolving needs, and enhance reporting models in a dynami...
1 week ago
$110K - $130K *
Lead strategic initiatives by managing complex projects from inception to launch. Collaborate across teams to implement new markets and contracts, ensuring compliance and operational readiness in a dy...
1 week ago
VP Business Development - Auto - Heavy Equipment Solutions
$150K - $180K *
Advance business growth by building strategic relationships and identifying client needs. Drive sales initiatives and ensure seamless implementation of client programs while meeting profit margins and...
1 week ago
Enterprise Applications Manager
$110K - $130K *
Manage and enhance enterprise applications, leading a team to ensure optimal performance, support, and user satisfaction while collaborating with IT and vendors to drive improvements and maintain docu...
1 week ago
Enterprise Applications Manager
$100K - $120K *
Manage and enhance enterprise applications, leading a team to ensure optimal performance, support, and user satisfaction while collaborating with IT and vendors to drive improvements and maintain docu...
1 week ago
Director of SiteWorks-Project Management
$110K - $130K *
Lead the charge in project management excellence, overseeing a dynamic team to ensure financial performance and client satisfaction across a diverse portfolio of construction projects. Drive continuou...
1 week ago
$135K - $160K *
Optimize backend systems for a financial platform, integrating AI features and ensuring reliability across multiple regions. Collaborate with global teams to enhance product capabilities and maintain...
1 week ago
$95K - $115K *
Shape the future of materials management by leading a cohesive team. Ensure material availability, optimize inventory, and drive supplier performance to meet production needs. Engage in continuous imp...
Reposted 1 week ago
$80K - $95K *
Engineer and develop functional tests for embedded firmware in advanced metering infrastructure. Collaborate with a team to ensure quality and compliance in electronic systems, contributing to innovat...
Reposted 1 week ago
Automation Manager - Centralia, MO
$95K - $115K *
Reimagine automated systems by leading a talented team of technicians to enhance equipment reliability, safety, and productivity through effective maintenance, troubleshooting, and continuous improvem...
Reposted 1 week ago
Senior Forward Deployed UX Designer (Asheville, NC or Nashville, TN)
$140K - $223K *
Unlock potential by leading human-centered design efforts in clinical settings, translating user insights into AI-enabled solutions that enhance patient care and clinician efficiency within a collabor...
1 week ago
$110K - $150K *
Engage as a key Contract Manager, overseeing procurement agreements and providing strategic guidance across teams. Collaborate on complex projects, ensuring compliance and effective negotiation while...
1 week ago
$100K - $160K *
Lead critical evaluations of biological risks, mentor junior specialists, and ensure high-quality labeling for AI safety classifiers in a dynamic life-sciences environment focused on biodefense and bi...
1 week ago
$160K - $229K *
Transform client experiences by leading SAP CX solutions, ensuring seamless integration and delivery from discovery to go-live while collaborating with cross-functional teams to drive business success...
1 week ago
Operations Support & Strategy Manager
$109K - $144K *
Join a dynamic team to drive operational excellence and process improvements in healthcare. Lead complex initiatives, influence strategy, and enhance care delivery while collaborating across multiple...
1 week ago
$133K - $173K *
Unlock potential by leading the commissioning of hyperscale data centers. Manage project lifecycles, coordinate teams, and ensure compliance with client requirements while fostering strong stakeholder...
1 week ago
Executive Director Surgical Service
$150K - $180K *
Manage and coordinate patient scheduling and inventory control while enhancing operational efficiency. Collaborate across departments to develop business strategies, oversee budgets, and maintain comp...
Reposted 1 week ago
Account Manager, Client Development & Renewals (Chicago / Midwest)
$123K - $135K *
Engage with existing customer accounts to drive renewal retention and expansion revenue. Collaborate with cross-functional teams to identify growth opportunities and ensure customer satisfaction while...
1 week ago
Chief Editorial and Insights Officer
$200K - $210K *
Champion innovative content strategies to transform editorial operations, enhance audience engagement, and establish a trusted resource for leaders in government and education. Drive organizational ch...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.