Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Healthcare Customer Success Executive, Sr.
$110K - $130K *
Drive customer success by fostering executive relationships and ensuring retention and growth across a defined portfolio. Leverage strategic insights to translate customer outcomes into measurable bus...
1 week ago
Communications Specialist, Education Systems & Policy
$96K - $102K *
Join a dynamic team to develop and implement strategic communications initiatives that translate complex research into engaging content for diverse audiences, enhancing visibility and impact across ed...
1 week ago
Account Manager, Molecular Diagnostics, QIAstat (Midwest)
$100K - $120K *
Advance healthcare solutions by driving sales of innovative diagnostic instruments. Engage with key stakeholders to promote QIAstat-Dx systems, ensuring successful adoption and customer satisfaction t...
1 week ago
HCP Personal Marketing Lead - Epilepsy
$190K - $214K *
Lead HCP personal promotion strategy, developing and optimizing initiatives that engage healthcare professionals. Collaborate cross-functionally to ensure compliance and effectiveness in promotional t...
1 week ago
Manufacturing Process and Packaging Engineer - Joplin, MO (Blue Buffalo)
$71K - $107K *
Drive operational excellence as a Manufacturing Process and Packaging Engineer, enhancing system performance and product quality. Collaborate with teams to troubleshoot, optimize processes, and implem...
1 week ago
Sr. Staff Applied AI Engineer, GTM
$180K - $225K *
Lead the charge in transforming AI strategies into impactful solutions for revenue teams, collaborating closely with GTM leaders to drive innovation and measurable outcomes while enhancing engineering...
1 week ago
21GRAMS- Associate Creative Director, Art
$160K - $180K *
Elevate healthcare creativity by leading innovative campaigns that transform client brands. Collaborate with teams to deliver impactful experiences across digital channels, leveraging insights and eme...
1 week ago
Azure Application Engineering Lead
$125K - $150K *
Join a team that's redefining cloud solutions by architecting and delivering complex Azure engagements. Lead migrations, mentor engineers, and drive innovation while ensuring robust security and gover...
1 week ago
Branch Real Estate Legal Advisory Lead
$120K - $145K *
Play a key role in shaping strategic real estate decisions by guiding complex leasing and portfolio transactions, balancing legal insights with business objectives to drive growth and innovation acros...
Reposted 1 week ago
Manager, Customer Engagement (Remote)
$100K - $112K *
Join a team that's transforming customer engagement through innovative product launches. You'll lead cross-functional collaboration, develop training materials, and ensure readiness for market, all wh...
1 week ago
$101K - $152K *
Champion operational excellence by managing production scheduling and supply chain activities. Collaborate with cross-functional teams to drive continuous improvement and ensure optimal plant performa...
1 week ago
$120K - $145K *
Join the forefront of quality assurance in government logistics. Lead the development and enhancement of a robust Quality Management System across multiple sites, ensuring compliance and operational e...
1 week ago
$76K - $124K *
Engage in foundational sales support, collaborating with Client Account Executives to develop skills in territory strategy, deal mechanics, and enterprise sales, while preparing for a quota-carrying r...
1 week ago
$100K - $120K *
Shape the future of automotive sales by leading a dynamic team, developing strategic initiatives, and engaging directly with clients to enhance their repair processes while achieving ambitious sales t...
1 week ago
Senior Analyst, AML Investigations
$97K - $115K *
Unlock insights into financial crime by investigating complex AML cases, driving compliance initiatives, and collaborating with stakeholders to enhance detection models and operational efficiency in a...
1 week ago
$150K - $200K *
Bring your expertise to lead sales strategies and customer development across NCC and VIS product lines, driving profitable growth and enhancing commercial processes while fostering collaboration with...
Reposted 1 week ago
Supervisory Criminal Investigator (Special Agent in Charge) Temp NTE 1 Year, MBE 2 years, MBMP
$100K - $120K *
Lead strategic planning and execution of investigative programs, ensuring alignment with organizational goals. Oversee multiple teams, manage resources, and provide expert guidance on law enforcement...
1 week ago
$79K - $109K *
Transform financial operations by owning monthly close processes, ensuring accurate COGS and accruals. Collaborate with leadership to drive data-driven decisions in a dynamic, growth-stage tech enviro...
1 week ago
Account Executive, Enterprise Suite - Financial Services
$124K - $171K *
Accelerate sales growth by managing and qualifying strategic Enterprise Intelligence opportunities. Collaborate with cross-functional teams, ensuring comprehensive engagement and communication to opti...
Reposted 1 week ago
$100K - $120K *
Join a team that's committed to operational excellence, overseeing technical operations and maintenance for a federal courthouse. Lead a skilled team to ensure safety, reliability, and compliance whil...
1 week ago
Supervisory Criminal Investigator (Special Agent in Charge) Temp NTE 1 Year, MBE 2 years, MBMP
$100K - $120K *
Lead strategic planning and execution of criminal investigations, ensuring compliance with IRS objectives. Oversee subordinate units, manage resources, and advise on legal matters to enhance operation...
1 week ago
Senior Financial Analyst, Corporate FP&A
$115K - $151K *
Advance your career by leading financial reporting and forecasting efforts. Collaborate across departments to analyze data, streamline processes, and support strategic planning in a dynamic, high-grow...
1 week ago
Senior Product Manager, Secret Detection and Vulnerability Research
$138K - $165K *
Drive GitLab's Secret Detection and Vulnerability Research efforts to shape security product outcomes. Own the detection lifecycle, ensure content quality, and leverage AI to enhance operational effic...
Reposted 1 week ago
$150K - $180K *
Drive innovation in power systems architecture by collaborating with hyperscalers and partners to develop cutting-edge connector and cable solutions. Lead technical programs, influence strategic objec...
1 week ago
Physician (Diagnostic Radiologist)
$210K - $250K *
Empower patient care through expert image interpretation and guidance in diagnostic radiology. Collaborate on quality assurance, oversee technical standards, and educate staff while ensuring optimal p...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.