Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $145K *

Partner with us to drive sales growth and elevate client relationships. Utilize tailored product demos and consultative techniques to enhance customer satisfaction and revenue, while leveraging your e...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$88K - $105K *

Transform your career by leading strategic marketing initiatives that enhance brand visibility and drive revenue growth. Collaborate with cross-functional teams to create compelling content and optimi...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Lead strategic planning and execution of investigative programs, ensuring alignment with organizational goals. Oversee multiple units, manage resources, and provide guidance to enhance operational eff...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Drive strategic initiatives and oversee program execution within the Criminal Investigation division, ensuring alignment with IRS goals. Lead teams, manage resources, and enhance investigative effecti...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Join a team that's building the Keycard Agent SDK to empower developers by enhancing trust, governance, and telemetry for AI agents. Collaborate on innovative solutions across multiple languages and f...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$139K - $235K *

Lead the charge in transforming investor relations processes, enhancing communication of strategy and performance to the market. Collaborate with executives to manage investor relationships and delive...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$222K - $278K *

Join a dynamic team to drive enterprise sales, transforming industries through innovative technology. Engage with C-level executives, manage complex deals, and foster lasting relationships to enhance...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Drive the revenue cycle for a multi-state hospice organization, ensuring accurate and timely payments. Lead a team, manage vendor relationships, and implement best practices to optimize operations and...

1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$160K - $180K *

Elevate your career by driving sales in the U.S. healthcare market, engaging diverse stakeholders, and managing complex sales cycles to expand our national brain-network footprint through strategic pa...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's dedicated to enhancing third-party risk management. Oversee compliance assessments, drive risk mitigation strategies, and collaborate with cross-functional teams to ensure adherence...

Missouri, USRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$190K - $220K *

Champion innovation and execution as you lead product management across diverse e-commerce channels. Drive strategic roadmaps, manage global teams, and deliver cutting-edge solutions that enhance cust...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$120K - $145K *

Engage as a key security authority within the engineering team, guiding security best practices across Azure and Kubernetes. Own compliance posture and support engineers in making informed security de...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$115K - $150K *

Innovate at the forefront of database management, ensuring performance, reliability, and security in a high-volume SQL Server environment. Lead incident response and engineering solutions to enhance o...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $160K *

Unlock potential by leading complex cyber investigations, mentoring junior analysts, and analyzing sophisticated threats to safeguard AI systems from misuse. Drive impactful decisions and enhance safe...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$120K - $160K *

Engineer the future of critical facility commissioning by leading project teams, managing schedules, and ensuring compliance with design and safety standards. Drive successful project execution throug...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$160K - $229K *

Lead the design and development of AI-driven solutions within SAP S/4HANA, integrating advanced AI technologies to drive business transformation and innovation across enterprise environments. Mentor t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$123K - $135K *

Engage with existing customer accounts to drive renewal retention and expansion revenue. This growth-focused role emphasizes consultative upselling and cross-selling, ensuring customer satisfaction wh...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $141K *

Join a team that's dedicated to providing expert bioinformatics support, bridging customer needs with innovative NGS solutions. You'll play a key role in pre- and post-sales activities, ensuring custo...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $175K *

Advance veterinary care by joining a supportive team dedicated to high-quality pet health. Enjoy flexible scheduling, competitive compensation, and opportunities for professional growth in a collabora...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$180K - $200K *

Lead water infrastructure strategies, ensuring efficient design and compliance across data center projects. Collaborate with teams to secure agreements and manage risks, enhancing sustainability and c...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Empower our engineering teams by leading technical recruitment efforts. Dive deep into candidate sourcing, build strong pipelines, and enhance the hiring process while ensuring a positive candidate ex...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $145K *

Lead campaign strategy and execution for oncology pharma marketing, driving performance optimization and cross-functional collaboration. Own end-to-end campaign management, ensuring alignment with bus...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$69K - $98K *

Take ownership of laboratory data management as a LIMS Administrator, ensuring accurate master data, enhancing system functionality, and supporting users. Collaborate across teams to drive improvement...

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$170K - $220K *

Lead the charge in providing comprehensive legal support for the CHVAC segment, collaborating with global teams to ensure compliance and address complex legal matters while driving strategic initiativ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Lead the charge in quality and validation readiness for complex programs, uniting Engineering, Product, and Customer Success teams. Utilize AI and automation to streamline processes, enhance delivery...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.