Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$82K - $113K *

Join a team that's dedicated to innovative product design and development. Collaborate with cross-functional teams, lead projects, and ensure compliance with industry standards while utilizing your en...

Reposted today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$157K - $192K *

Develop and enhance a cloud-native agent harness, ensuring secure, reliable, and efficient operations. Collaborate with a dynamic team to deliver features, fix bugs, and innovate using AI throughout t...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$94K - $117K *

Unlock your potential as a key underwriter, evaluating complex insurance applications and guiding risk assessment. Collaborate with a dynamic team to enhance underwriting practices while fostering rel...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$111K - $197K *

Champion integration solutions by leading projects, conducting discovery sessions, and implementing complex integrations for clients in Higher Education and Nonprofit sectors. Drive results and ensure...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Consumer Technology

$125K - $150K *

Accelerate growth by leading commercial strategy and sales for Mid-Market & SMB segments. Drive revenue, manage KPIs, and collaborate cross-functionally to enhance client satisfaction and market prese...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$130K - $160K *

Deliver high-quality telemedicine care to complex patients, focusing on symptom management and improving outcomes. Collaborate with a multidisciplinary team to enhance patient experiences and facilita...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Champion innovation in AI engineering by building intelligent systems that enhance productivity and streamline workflows, enabling teams to deliver exceptional user experiences and drive the future of...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Consumer Technology

$140K - $160K *

Design and enhance intelligent AI systems for K-12 assessment, collaborating across disciplines to create reliable, evaluative solutions that integrate seamlessly into educational frameworks and suppo...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Transform the BCP business by leading product strategies, optimizing sales performance, and enhancing customer engagement. Drive growth through analytics, competitive insights, and effective program m...

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$123K - $155K *

Lead the charge in enhancing incident management practices across global data centers. Collaborate with teams to develop standards, improve processes, and drive operational excellence, ensuring effect...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$270K - $340K *

Unlock potential by driving sales for innovative healthcare compliance solutions. Own the full sales cycle with health plans, transforming initial conversations into lasting partnerships while shaping...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Manage the full sales cycle for mid-sized jurisdictions, focusing on pipeline growth and relationship building. Drive revenue through prospecting, closing deals, and collaborating with cross-functiona...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Consumer Technology

$229K - $330K *

Join us to redefine revenue operations by leading a dynamic team that transforms GTM strategies into actionable insights, ensuring scalable success across diverse market segments and driving AI-enhanc...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$100K - $115K *

Engineer innovative Salesforce solutions and integrations, enhancing business applications and operational efficiency. Collaborate with cross-functional teams to deliver secure, scalable technology th...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Accelerate progress at customer deployments and adoption, driving value realization across a portfolio of accounts. Leverage technical fluency and business acumen to ensure successful outcomes and dee...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$157K - $183K *

Unlock innovative Finance and Accounting outsourcing solutions by leading design and development efforts. Collaborate with cross-functional teams to optimize service delivery and drive strategic clien...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Business Services

$110K - $130K *

Drive team success as you lead a dynamic paid advertising group, fostering growth and innovation. Oversee client accounts, ensuring high-quality execution and strategic insights while mentoring team m...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Drive the design and delivery of impactful IT training programs, collaborating with cross-functional teams to enhance employee skills and support technology initiatives across various learning levels...

Today

  •   Less than 5 years exp.  •   Real Estate & Construction

$150K - $200K *

Join us in a pivotal leadership role to enhance customer success initiatives, drive operational excellence, and build a high-performing team focused on customer engagement and retention strategies in...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Innovate your career by leading the strategy and creation of impactful B2B content across various formats. Collaborate with teams to enhance engagement and drive demand through high-quality, optimized...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Energy & Utilities

$165K - $195K *

Accelerate the recruitment process for early-career talent, leading strategy and execution for cohort hiring. Collaborate across teams to ensure alignment and quality, while leveraging data and AI to...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $144K *

Transform client relationships and elevate service delivery by managing Building Automation System programs. Combine hands-on technical expertise with leadership to ensure high-quality support in crit...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Technical Services

$135K - $160K *

Empower your career by leading a dynamic team in strategic account management, driving product adoption, and maximizing growth for top-tier clients in the media and technology sectors. Shape the futur...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Shape the future of hotel technology by owning the end-to-end booking experience, bridging guest interactions and hotel-focused workflows to drive measurable business value through innovative solution...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Hospitality & Recreation

$108K - $149K *

Inspire growth by leading a regional sales team to achieve goals, enhancing customer experiences, and developing effective training programs while driving profitable revenue through strategic leadersh...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.