Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$108K - $130K *
Empower enterprise infrastructures by designing automated workflows for secure, scalable network management. Utilize advanced scripting and automation to optimize systems while leveraging your experti...
Reposted 1 week ago
Nurse Practitioner / Physician Assistant - Texas
$140K - $150K *
Join a team that's dedicated to transforming addiction treatment through telehealth. Collaborate with physicians to provide comprehensive care for patients with substance use disorders, ensuring a sup...
1 week ago
$160K - $180K *
Transform digital healthcare services by designing and deploying scalable machine learning models. Collaborate with cross-functional teams to enhance predictive capabilities and ensure compliance with...
1 week ago
$160K - $190K *
Champion innovative solutions as a Technical Architect, leading customer engagements to integrate Salesforce and AI technologies. Drive adoption and optimize implementations while mentoring teams and...
1 week ago
$108K - $130K *
Drive successful battery energy storage projects by managing installations, ensuring quality, and maintaining customer satisfaction. Collaborate with cross-functional teams to deliver projects on time...
1 week ago
$184K - $200K *
Unlock potential by driving the vision and strategy for innovative products that empower independent candidates and enhance user engagement. Collaborate with cross-functional teams to create scalable...
Reposted 1 week ago
Junior Salesforce Developer | Public Health
$81K - $98K *
Advance your career by leveraging your public health expertise and Salesforce skills to develop impactful solutions. Collaborate with a dedicated team to enhance public health technology, ensuring it...
Reposted 1 week ago
Client Partner - Consumer Products & Retail (remote)
$210K - $250K *
Transform client relationships and drive AI-led growth in the Consumer Products, Manufacturing & Retail sectors. Lead strategic accounts, mentor teams, and shape innovative solutions to enhance busine...
1 week ago
Senior Vice President, Consumer Panel & Behavior Products| Level 22| US: Remote
$325K - $343K *
Lead the charge in shaping the product vision and strategy for consumer panel and behavioral measurement solutions, driving growth through innovative AI-native practices and client collaboration...
1 week ago
Sr. Manager, Software Engineering - Computer Backup
$205K - $255K *
Join a team that's shaping the future of data protection by leading the Computer Backup engineering team. Drive technical direction, manage budgets, and enhance collaboration across desktop and backen...
1 week ago
$85K - $100K *
Elevate your career by providing essential physical therapy services in home settings. Collaborate with healthcare teams to enhance patient mobility and well-being while enjoying a supportive work-lif...
1 week ago
$105K - $130K *
Elevate patient care by managing clinical support for monitoring systems. Lead diverse teams to enhance customer relationships and ensure effective product utilization post-implementation, driving cli...
Reposted 1 week ago
Director HR Business Partner - Remote
$155K - $259K *
Champion organizational success by leading HR strategies, guiding senior leaders, and fostering an inclusive workplace. Leverage HR expertise to enhance talent management and drive business performanc...
1 week ago
Remote PMO Senior Quality Analyst (VA ESOM)
$100K - $115K *
Optimize quality analytics and reporting for program deliverables, ensuring compliance with standards and client expectations. Collaborate with senior leaders to provide actionable insights and drive...
1 week ago
$150K - $200K *
Champion technical evaluations by partnering with sales to showcase AI solutions, architect tailored implementations, and drive successful customer engagements, ensuring prospects experience the full...
1 week ago
$75K - $90K *
Transform client objectives into impactful paid social strategies. Oversee campaign execution, optimize performance, and mentor junior team members while driving cross-functional collaboration to achi...
1 week ago
Systems and Integration Architect
$108K - $130K *
Lead the charge in designing and implementing innovative software solutions that enhance network operations. Collaborate with cross-functional teams to automate processes, improve efficiency, and ensu...
1 week ago
$130K - $160K *
Lead all HR functions in a dynamic biotech environment, enhancing employee experience and compliance while driving scalable processes and supporting leadership. Engage with teams to foster growth and...
1 week ago
Lifecycle Marketing Specialist, Customer Journey
$72K - $90K *
Optimize customer journeys by owning lifecycle initiatives, translating strategy into actionable requirements, and driving performance improvements. Collaborate with cross-functional teams to enhance...
1 week ago
$125K - $150K *
Unlock growth by leading RevOps initiatives that enhance acquisition, strengthen pipelines, and optimize seller performance through data-driven strategies and robust analytics, ensuring alignment with...
Reposted 1 week ago
$89K - $165K *
Engage in complex engineering design and analysis, tackling technical challenges and enhancing product development. Collaborate across teams to drive innovation and ensure quality in high voltage syst...
1 week ago
Manager, Distribution Readiness & Field Excellence (Remote, US)
$100K - $120K *
Contribute to the development of our sales team by implementing systems for skill enhancement, performance tracking, and strategic field execution, aiming for excellence in agency collaborations and m...
Reposted 1 week ago
Clinical Trial Liaison (Oncology)
$100K - $120K *
Accelerate progress at clinical sites by enhancing patient recruitment strategies and supporting Oncology studies. Collaborate with teams to optimize enrollment processes and ensure effective communic...
1 week ago
$210K - $250K *
Transform patient care by providing specialized gastroenterology services, including diagnosis and treatment of GI disorders. Collaborate with a multidisciplinary team to enhance patient outcomes in b...
1 week ago
AWS FS Ecosystem Business Development Senior Manager
$132K - $302K *
Join a team that's driving cloud innovation by developing strategic partnerships and executing go-to-market strategies for AWS offerings. Leverage your expertise to enhance client engagement and grow...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.