Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$108K - $130K *

Empower enterprise infrastructures by designing automated workflows for secure, scalable network management. Utilize advanced scripting and automation to optimize systems while leveraging your experti...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $150K *

Join a team that's dedicated to transforming addiction treatment through telehealth. Collaborate with physicians to provide comprehensive care for patients with substance use disorders, ensuring a sup...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $180K *

Transform digital healthcare services by designing and deploying scalable machine learning models. Collaborate with cross-functional teams to enhance predictive capabilities and ensure compliance with...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $190K *

Champion innovative solutions as a Technical Architect, leading customer engagements to integrate Salesforce and AI technologies. Drive adoption and optimize implementations while mentoring teams and...

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$108K - $130K *

Drive successful battery energy storage projects by managing installations, ensuring quality, and maintaining customer satisfaction. Collaborate with cross-functional teams to deliver projects on time...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$184K - $200K *

Unlock potential by driving the vision and strategy for innovative products that empower independent candidates and enhance user engagement. Collaborate with cross-functional teams to create scalable...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Business Services

$81K - $98K *

Advance your career by leveraging your public health expertise and Salesforce skills to develop impactful solutions. Collaborate with a dedicated team to enhance public health technology, ensuring it...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$210K - $250K *

Transform client relationships and drive AI-led growth in the Consumer Products, Manufacturing & Retail sectors. Lead strategic accounts, mentor teams, and shape innovative solutions to enhance busine...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$325K - $343K *

Lead the charge in shaping the product vision and strategy for consumer panel and behavioral measurement solutions, driving growth through innovative AI-native practices and client collaboration...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$205K - $255K *

Join a team that's shaping the future of data protection by leading the Computer Backup engineering team. Drive technical direction, manage budgets, and enhance collaboration across desktop and backen...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $100K *

Elevate your career by providing essential physical therapy services in home settings. Collaborate with healthcare teams to enhance patient mobility and well-being while enjoying a supportive work-lif...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$105K - $130K *

Elevate patient care by managing clinical support for monitoring systems. Lead diverse teams to enhance customer relationships and ensure effective product utilization post-implementation, driving cli...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$155K - $259K *

Champion organizational success by leading HR strategies, guiding senior leaders, and fostering an inclusive workplace. Leverage HR expertise to enhance talent management and drive business performanc...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$100K - $115K *

Optimize quality analytics and reporting for program deliverables, ensuring compliance with standards and client expectations. Collaborate with senior leaders to provide actionable insights and drive...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $200K *

Champion technical evaluations by partnering with sales to showcase AI solutions, architect tailored implementations, and drive successful customer engagements, ensuring prospects experience the full...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $90K *

Transform client objectives into impactful paid social strategies. Oversee campaign execution, optimize performance, and mentor junior team members while driving cross-functional collaboration to achi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$108K - $130K *

Lead the charge in designing and implementing innovative software solutions that enhance network operations. Collaborate with cross-functional teams to automate processes, improve efficiency, and ensu...

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$130K - $160K *

Lead all HR functions in a dynamic biotech environment, enhancing employee experience and compliance while driving scalable processes and supporting leadership. Engage with teams to foster growth and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$72K - $90K *

Optimize customer journeys by owning lifecycle initiatives, translating strategy into actionable requirements, and driving performance improvements. Collaborate with cross-functional teams to enhance...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Unlock growth by leading RevOps initiatives that enhance acquisition, strengthen pipelines, and optimize seller performance through data-driven strategies and robust analytics, ensuring alignment with...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$89K - $165K *

Engage in complex engineering design and analysis, tackling technical challenges and enhancing product development. Collaborate across teams to drive innovation and ensure quality in high voltage syst...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Contribute to the development of our sales team by implementing systems for skill enhancement, performance tracking, and strategic field execution, aiming for excellence in agency collaborations and m...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Accelerate progress at clinical sites by enhancing patient recruitment strategies and supporting Oncology studies. Collaborate with teams to optimize enrollment processes and ensure effective communic...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Transform patient care by providing specialized gastroenterology services, including diagnosis and treatment of GI disorders. Collaborate with a multidisciplinary team to enhance patient outcomes in b...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$132K - $302K *

Join a team that's driving cloud innovation by developing strategic partnerships and executing go-to-market strategies for AWS offerings. Leverage your expertise to enhance client engagement and grow...

1 week ago

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.