Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $210K *

Advance your career by designing innovative Anaplan solutions that address client needs while leading Agile projects and training teams. Shape the technical vision and enhance processes for impactful...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$87K - $157K *

Transform your career by joining a dynamic team to design and deploy next-generation air traffic control systems, ensuring safety and efficiency across the National Airspace System through innovative...

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$92K - $166K *

Champion enterprise compensation programs by managing operations, analytics, and job architecture. Collaborate with HR and business leaders to ensure compliance and drive strategic initiatives in a dy...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$73K - $132K *

Join a team that's dedicated to innovation and excellence in various roles, from engineering to intelligence. Contribute your skills to impactful projects that enhance national security and technologi...

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$107K - $195K *

Drive mission-critical operations and cybersecurity for a federal health data exchange. Lead 24x7 platform management, incident response, and vulnerability remediation to ensure seamless service for m...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$92K - $166K *

Elevate team performance by facilitating agile processes, removing impediments, and ensuring alignment between stakeholders and development teams. Drive continuous improvement and deliver value throug...

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$73K - $132K *

Shape the future of national security by leveraging advanced data analysis and imagery expertise. Collaborate with a dynamic team to support critical missions and drive innovation in intelligence oper...

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$69K - $125K *

Optimize site deployment for FAA NextGen programs by leading coordination, communication, and technical support. Ensure successful installation, maintenance, and certification of systems while managin...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$59K - $106K *

Join a team that's dedicated to delivering high-quality photogrammetry support. Collaborate with senior specialists to produce remote reconnaissance packages for geodetic surveys, utilizing advanced d...

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$123K - $137K *

Lead site management activities by overseeing installation teams, ensuring project success through effective communication, risk mitigation, and adherence to quality standards across all on-site opera...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$134K - $201K *

Design and engineer identity governance solutions to ensure secure access across diverse environments. Collaborate with cross-functional teams to implement standards, automate workflows, and maintain...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$204K - $327K *

Drive innovative legal solutions as a key partner for AI and product teams, providing comprehensive guidance on regulatory challenges and product development. Collaborate cross-functionally to ensure...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$263K - $395K *

Transform the technical landscape by defining and delivering innovative solutions, mentoring engineers, and shaping strategic initiatives to enhance system architecture and performance across the orga...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$92K - $139K *

Drive customer success by managing a portfolio of enterprise accounts, ensuring optimal software utilization, and fostering strong relationships to enhance client satisfaction and revenue growth...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Evaluate and analyze the creditworthiness of commercial borrowers, preparing detailed credit analyses and recommendations to support lending decisions while collaborating with banking professionals to...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$137K - $155K *

Lead digital transformation initiatives to enhance vegetable seed processing operations. Drive change management, develop data solutions, and optimize digital tools for global integration, ensuring su...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $131K *

Transform complex data into actionable insights, partnering with leaders to enhance strategic decision-making and drive organizational performance through advanced analytics and reporting frameworks...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$91K - $163K *

Transform patient care by leveraging your clinical expertise to ensure safe, effective medication management. Collaborate with healthcare teams to optimize drug therapy and enhance patient outcomes in...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$200K - $240K *

Lead the charge in enterprise sales by acquiring new logos and building strategic relationships. Drive growth in a competitive market, leveraging your expertise to navigate complex sales cycles and de...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K *

Champion operational excellence by leading production across multiple markets, enhancing customer satisfaction, and driving efficiency in a dynamic residential remodeling environment...

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$108K - $129K *

Champion innovative manufacturing solutions by leading design feedback, quoting, and DFM initiatives. Collaborate cross-functionally to enhance product manufacturability and mentor engineers, driving...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Drive innovation by enhancing Finance systems through design, implementation, and analytics. Collaborate with cross-functional teams to ensure data integrity and optimize processes, while mentoring an...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Lead the charge in driving sales for hazardous products across Oregon and Western Washington. Cultivate strong relationships with distributors and contractors to achieve sales targets and enhance prod...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Drive website optimization and search strategy initiatives, enhancing digital visibility and engagement. Collaborate with cross-functional teams to implement SEO, GEO, and technical strategies that el...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$170K - $185K *

Drive impactful IT program initiatives for Federal and SLED Governments, overseeing planning, execution, and financial management while fostering client relationships and identifying growth opportunit...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.