Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Senior Cost Manager / Quantity Surveyor - Data Center Construction
$110K - $130K *
Empower project success by leading cost management for a large-scale data center program. Collaborate with clients and teams to ensure accurate cost planning, procurement strategies, and change manage...
1 week ago
Director - Population Health & Well Being
$150K - $160K *
Lead the charge in executing population health strategies, ensuring high-quality consulting delivery and team performance across regions. Collaborate with leadership to drive impactful solutions and f...
1 week ago
$110K - $140K *
Transform infrastructure and deployment modernization efforts, serving as a technical cornerstone for multiple programs. Drive DevSecOps maturity and cloud adoption while ensuring secure, rapid delive...
1 week ago
$101K - $165K *
Transform co-marketing initiatives by executing strategic campaigns across diverse channels. Collaborate with partners and cross-functional teams to drive revenue growth, enhance brand awareness, and...
1 week ago
Associate / Analyst, Strategic Initiatives
$90K - $120K *
Advance strategic initiatives by collaborating across teams to launch innovative data tools and insurance programs. Drive project management efforts and contribute to executive presentations that shap...
1 week ago
$125K - $165K *
Join a dynamic team to oversee complex life application underwriting, ensuring risk selection aligns with financial goals. Drive process improvements and collaborate with stakeholders to enhance servi...
1 week ago
$85K - $100K *
Drive clinical excellence by partnering with agency leaders to assess, develop, and deliver tailored education programs for nursing staff, ensuring compliance and enhancing patient care across a netwo...
1 week ago
Behavioral Health Medical Director
$223K - $313K *
Shape the future of behavioral health care strategy and operations. Leverage your medical expertise to enhance quality, operational efficiency, and patient outcomes while navigating complex regulatory...
Reposted 1 week ago
Senior Applications Analyst - Billing
$123K - $207K *
Elevate enterprise systems by leading design and enhancements, ensuring reliability and usability. Collaborate with cross-functional teams to translate requirements into scalable solutions while drivi...
1 week ago
Senior Manager, AI Advisory and Open Source Program Office
$200K - $250K *
Unlock the potential of Open Source and AI governance by leading a multidisciplinary team to ensure compliance, drive best practices, and foster innovation across the enterprise, while collaborating w...
1 week ago
Project Manager - Enterprise Project Management Office
$96K - $125K *
Deliver cross-functional project management and business analysis for complex initiatives, ensuring timely and compliant project execution while collaborating with stakeholders to drive measurable val...
1 week ago
Senior Software Developer (Remote)
$108K - $130K *
Contribute to the development of innovative web applications using .Net, Angular, and SQL. Collaborate with a dynamic team to enhance existing systems and design new solutions, ensuring high-quality s...
1 week ago
$100K - $125K *
Champion data engineering excellence by designing and maintaining robust data pipelines and analytics solutions. Collaborate with stakeholders to enhance data quality and support enterprise-level data...
1 week ago
Senior Manager, People Operations
$120K - $130K *
Optimize the employee experience through innovative engagement strategies and precise HR operations. Be a key player in fostering a vibrant culture while ensuring operational excellence in onboarding...
Reposted 1 week ago
Director, Operational Excellence & Advanced Engineering (RE925)
$125K - $150K *
Optimize enterprise-wide manufacturing through Lean strategies and advanced engineering solutions. Lead initiatives to enhance safety, quality, and productivity while fostering a culture of operationa...
1 week ago
Director, Operational Excellence & Advanced Engineering (RE925)
$125K - $150K *
Join a team that's driving operational excellence and advanced engineering across multiple sites. Lead initiatives in Lean, automation, and process improvement to enhance productivity, safety, and qua...
1 week ago
Territory Sales Manager, Commercial Trucking - IL
$104K - $161K *
Accelerate progress at driving agency relationships and revenue growth in the commercial trucking sector. Manage a diverse portfolio of accounts while implementing best practices to enhance sales perf...
1 week ago
Territory Sales Manager (Nebraska/Kansas)
$91K - $141K *
Empower agency growth by managing relationships and driving performance in Nebraska and Kansas. Lead strategic initiatives, deliver training, and ensure accountability to achieve sales goals while fos...
1 week ago
Solutions Architect, CTO Office - US
$150K - $180K *
Join us to tackle complex challenges as a strategic technical leader, influencing product direction and driving customer success. Your expertise will shape innovative solutions while engaging directly...
1 week ago
Senior Strategy & Decision Analyst
$120K - $145K *
Help us ensure high-quality decision-making by collaborating with leaders to frame strategies and analyze options, driving impactful decisions that align with organizational goals and values while fos...
1 week ago
$110K - $130K *
Join a team that's dedicated to enhancing patient care through safe, effective medication therapy. Collaborate with healthcare professionals to optimize treatment plans and serve as a trusted resource...
1 week ago
Manager, Claims Operations - Property Claims
$103K - $186K *
Manage claims operations to enhance member service and drive process improvements. Lead and develop a team through coaching, compliance management, and operational risk mitigation to achieve optimal p...
Reposted 1 week ago
Asset Manager, Global Realty Portfolio Management
$77K - $135K *
Join us to manage a diverse portfolio of 90-120 real estate assets, ensuring lease compliance and fostering strong landlord relationships while solving complex challenges across North America...
1 week ago
Deputy Director, Partnerships & Technical Integration
$196K - $210K *
Partner with us to shape the future of semiconductor workforce development by aligning industry needs with educational strategies, fostering partnerships, and leading initiatives that ensure technical...
Reposted 1 week ago
$98K - $134K *
Champion user-centered design as a Senior Product Designer, leading onboarding experiences that empower educators and learners. Collaborate across teams to create intuitive, impactful solutions that s...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.