Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$83K - $104K *

Lead safety initiatives on job sites, ensuring compliance and employee well-being. Collaborate with teams to implement protocols, conduct audits, and provide training, fostering a culture of safety ac...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $140K *

Drive impactful financial due diligence for M&A activities, collaborating with clients and executives to assess enterprise value and risks. Join a high-performing team dedicated to excellence in deal...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$82K - $100K *

Drive customer success by managing a portfolio of self-serve clients, ensuring effective onboarding, retention, and growth through strategic guidance and product expertise to achieve optimal business...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Shape the future of sales leadership by driving growth and profitability through effective team management, strategic execution, and customer engagement. Collaborate with stakeholders to enhance perfo...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$90K - $115K *

Lead the charge in managing high-exposure General Liability claims, developing strategies for resolution, and collaborating with clients and legal teams to deliver exceptional service in a dynamic, su...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock potential by joining a dynamic team of actuaries to support financial examinations and regulatory projects, with opportunities to engage in diverse consulting tasks across various insurance sec...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$94K - $224K *

Champion strategic internal communications to enhance engagement and alignment across global teams. Collaborate with leaders to translate business priorities into impactful messaging and drive transfo...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$80K - $200K *

Drive membership growth by engaging small business owners through face-to-face sales. Utilize your skills in prospecting, relationship building, and closing to achieve sales goals in a dynamic, indepe...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$145K - $185K *

Champion partner growth by developing and executing multi-tiered GTM strategies, driving revenue expansion across the MSSP and MSP ecosystem while collaborating with sales to enhance market awareness...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$88K - $105K *

Engage in complex EHR application analysis and configuration, collaborating with clinical teams to enhance system usage. Drive issue resolution and maintain application integrity in a remote setting...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join us to drive sales and enhance customer relationships by effectively promoting our product line, executing in-services, and analyzing market needs to achieve sales objectives in your designated ar...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$215K - $408K *

Drive medical leadership in quality improvement and utilization management, ensuring effective care delivery and cost containment. Collaborate with clinical teams to enhance patient outcomes and suppo...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join our team to drive innovation in eye care by presenting scientific insights, fostering relationships with medical experts, and influencing strategies to enhance patient outcomes through evidence-b...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$145K - $175K *

Champion EPAM's growth by leading Advisor Relations strategy across North America. Build trusted relationships with sourcing advisors to drive commercial opportunities and enhance market perception, a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$175K - $219K *

Help us elevate Field Medical operations by optimizing processes, enhancing communication, and driving strategic initiatives to ensure effective engagement and alignment across teams in a dynamic heal...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Support the design and maintenance of Electrical SCADA Systems, ensuring efficient monitoring and control of electrical power across various sites. Collaborate with engineers and stakeholders to enhan...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$106K - $146K *

Elevate community impact by coaching and mentoring Chapter Executive Directors, enhancing their leadership skills and strategic influence while overseeing a portfolio of five to six Chapters to ensure...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$250K - $300K *

Help us provide compassionate, patient-centered care to homebound seniors, managing chronic and acute conditions while collaborating with interdisciplinary teams to enhance health outcomes and ensure...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $90K *

Lead the charge in enhancing professional development for infant and early childhood mental health. Collaborate nationally to deliver high-quality training, support certification, and implement innova...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Shape the future of financial content by crafting engaging, SEO-driven copy that informs and converts. Collaborate with SEO experts and compliance teams to produce clear, compliant content that resona...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $160K *

Lead the charge in driving strategic sales growth within higher education, transforming complex challenges into solutions. Collaborate cross-functionally to enhance market share and establish lasting...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Drive impactful education for healthcare providers on patient support programs, ensuring effective communication and collaboration across teams. Leverage expertise in payer policies to enhance access...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$149K - $198K *

Champion the investigation and diagnosis of complex AV behaviors, driving solutions autonomously across simulation and on-road environments. Utilize Python and custom tools to enhance diagnostic capab...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$100K - $104K *

Manage daily property operations, lead a dedicated team, and drive leasing success while ensuring resident satisfaction and financial performance in a dynamic environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$70K - $102K *

Join a dynamic team driving innovation in pet nutrition by qualifying raw materials and suppliers. Collaborate across functions to enhance product quality and support new ingredient development in a f...

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.