Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$87K - $126K *

Drive ingredient innovation and quality improvement projects, collaborating with cross-functional teams to qualify new raw materials and suppliers, ensuring alignment with product specifications and b...

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$100K - $140K *

Help us drive growth by identifying and securing new clients through tailored software solutions, while collaborating with internal teams to enhance customer experience and achieve sales targets in a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$204K - $216K *

Unlock potential by designing robust data models that empower AI systems. You will ensure data coherence and quality, bridging knowledge representation and machine learning across diverse communities...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Transform patient care by delivering exceptional pharmacy services across multiple locations. Collaborate with teams, counsel patients, and ensure compliance while taking ownership in the absence of m...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $155K *

Join a team that's dedicated to global security by providing advanced threat hunting and intelligence analysis. Collaborate with top organizations to deliver actionable insights and safeguard environm...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $300K *

Unlock your potential by leading a patient-focused dental team, ensuring top-quality care, mentoring professionals, and driving operational success while staying updated on industry advancements...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$119K - $186K *

Manage legal services for indirect sourcing, delivering strategic counsel and project management. Negotiate vendor agreements and ensure compliance while collaborating with stakeholders to support bus...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$155K - $175K *

Engage and expand channel partnerships to drive revenue growth. Lead strategic initiatives, manage partner programs, and collaborate across teams to achieve business objectives in a fast-paced environ...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Unlock potential by developing innovative deep learning models to enhance financial decision-making. Collaborate with a skilled team to translate complex data science concepts into impactful solutions...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$97K - $145K *

Join a dynamic team to lead physician coding integration initiatives, ensuring operational readiness and compliance. Collaborate across departments to enhance coding practices and drive revenue cycle...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Transform project execution by leading design and construction initiatives. Manage budgets, timelines, and client expectations while fostering collaboration and ensuring project excellence from start...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Join us to drive regional sales growth by developing strategies, building a motivated team, and fostering strong customer relationships. Your leadership will be key in achieving financial targets and...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$92K - $125K *

Drive operational excellence in patient access by leading teams, enhancing processes, and fostering collaboration across healthcare facilities. Your leadership will ensure compliance, improve patient...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$108K - $130K *

Transform financial strategies by owning revenue forecasting, demand planning, and analytics. Collaborate across functions to drive growth and optimize performance, ensuring data integrity and actiona...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$131K *

Optimize patient care by compounding and dispensing medications, supervising pharmacy operations, and ensuring compliance with health regulations while providing exceptional customer service and suppo...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$95K - $115K *

Manage technical standards for topographic survey and data collection, ensuring quality and accuracy in methodologies. Collaborate with project teams to deliver reliable geospatial information for eng...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead a dynamic team to enhance customer success, drive retention, and maximize revenue growth. Shape strategies and workflows while collaborating cross-functionally to deliver exceptional value and ou...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$144K - $192K *

Champion innovative AI workflows and systems design, collaborating across teams to redefine complex processes. Drive strategic initiatives, enhance operational efficiency, and create AI-ready systems...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$83K - $104K *

Lead safety initiatives on job sites, ensuring compliance and employee well-being. Collaborate with teams to implement protocols, conduct audits, and provide training, fostering a culture of safety ac...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $140K *

Drive impactful financial due diligence for M&A activities, collaborating with clients and executives to assess enterprise value and risks. Join a high-performing team dedicated to excellence in deal...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$82K - $100K *

Drive customer success by managing a portfolio of self-serve clients, ensuring effective onboarding, retention, and growth through strategic guidance and product expertise to achieve optimal business...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Shape the future of sales leadership by driving growth and profitability through effective team management, strategic execution, and customer engagement. Collaborate with stakeholders to enhance perfo...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$90K - $115K *

Lead the charge in managing high-exposure General Liability claims, developing strategies for resolution, and collaborating with clients and legal teams to deliver exceptional service in a dynamic, su...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock potential by joining a dynamic team of actuaries to support financial examinations and regulatory projects, with opportunities to engage in diverse consulting tasks across various insurance sec...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$94K - $224K *

Champion strategic internal communications to enhance engagement and alignment across global teams. Collaborate with leaders to translate business priorities into impactful messaging and drive transfo...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.