Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$104K - $194K *

Transform your career by spearheading agency relationships and driving profitable Inland Marine solutions while managing a territory remotely, influencing business growth through strategic underwritin...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$155K - $197K *

Innovate as a Tech Lead, driving architectural evolution and engineering execution for a global web platform. Collaborate with cross-functional teams to enhance digital experiences through advanced AI...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $190K *

Unlock your potential as a key player in software development, leading projects from design to deployment. Collaborate with cross-functional teams to enhance applications, optimize performance, and dr...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$80K - $95K *

Join a team that's dedicated to expanding healthcare partnerships by identifying and nurturing relationships with hospitals. Drive innovative consignment solutions while collaborating with internal te...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$138K - $187K *

Lead cross-functional quality initiatives to enhance product health and compliance. Collaborate with diverse teams on regulatory submissions, quality assessments, and process improvements for late-sta...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $155K *

Join a team that's redefining product marketing by crafting compelling narratives and lifecycle campaigns that drive customer engagement and platform adoption across diverse segments. Collaborate with...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$88K - $105K *

Join a team that's dedicated to managing and growing medical device testing portfolios. This role bridges Business Development and Operations, ensuring client objectives are met through high-quality p...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$175K *

Champion enrollment growth by leading a high-performing team, optimizing processes, and enhancing the student experience. Collaborate cross-functionally to drive strategic initiatives and achieve meas...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Lead client interactions and drive technology solutions by leveraging AI and best practices. Collaborate with teams to enhance efficiency, mentor developers, and ensure alignment with business goals w...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$40K - $120K *

Join a dynamic automotive sales team to drive customer engagement and sales success. Manage the sales process from initial contact to delivery, ensuring a consultative experience that fosters relation...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$125K - $150K *

Join a dynamic team to enhance application security across web apps, APIs, and cloud services. Collaborate with development squads to prioritize vulnerabilities and implement proactive remediation str...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $181K *

Manage and grow a diverse portfolio of health plan customers, driving satisfaction and retention. Build strategic relationships, navigate complex payor landscapes, and champion clinical outcomes to de...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$168K - $281K *

Lead the charge in Proactive Defense Operations, transforming threat data into automated defenses. Drive strategy, team performance, and operational excellence while collaborating across functions to...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock potential by leading compliance audits, ensuring accurate coding and documentation in anesthesia. Collaborate with teams to mitigate risks, deliver training, and maintain regulatory standards w...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Advance sales performance by leading a dynamic team, driving revenue growth, and optimizing strategies through collaboration with operations and marketing to achieve business objectives...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$125K - $150K *

Pioneer data-driven growth strategies to enhance subscription revenue through analytics, experimentation, and automation. Collaborate cross-functionally to implement impactful changes across acquisiti...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$93K - $104K *

Join a dynamic team to deliver high-quality audiologic evaluations remotely. Leverage your expertise in a supportive environment, enhancing patient care while minimizing administrative burdens and max...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$113K - $142K *

Elevate your career by joining our dynamic team to design, develop, and optimize bioinformatics software tools and systems, ensuring robust functionality and compliance in a fast-paced, innovative env...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$87K - $126K *

Drive ingredient innovation and quality improvement projects, collaborating with cross-functional teams to qualify new raw materials and suppliers, ensuring alignment with product specifications and b...

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$100K - $140K *

Help us drive growth by identifying and securing new clients through tailored software solutions, while collaborating with internal teams to enhance customer experience and achieve sales targets in a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$204K - $216K *

Unlock potential by designing robust data models that empower AI systems. You will ensure data coherence and quality, bridging knowledge representation and machine learning across diverse communities...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Transform patient care by delivering exceptional pharmacy services across multiple locations. Collaborate with teams, counsel patients, and ensure compliance while taking ownership in the absence of m...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $155K *

Join a team that's dedicated to global security by providing advanced threat hunting and intelligence analysis. Collaborate with top organizations to deliver actionable insights and safeguard environm...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $300K *

Unlock your potential by leading a patient-focused dental team, ensuring top-quality care, mentoring professionals, and driving operational success while staying updated on industry advancements...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$119K - $186K *

Manage legal services for indirect sourcing, delivering strategic counsel and project management. Negotiate vendor agreements and ensure compliance while collaborating with stakeholders to support bus...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.