Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$135K - $160K *

Lead the strategic design and management of comprehensive benefits programs, ensuring alignment with employee needs and company objectives. Drive innovation and compliance while enhancing employee eng...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Grow your career by driving revenue growth in the acute care market through new customer acquisition and account expansion. Manage the full sales lifecycle while collaborating with internal teams to d...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$97K - $132K *

Unlock the potential of cloud infrastructure by managing application migrations, bridging gaps between systems, and optimizing processes. Work collaboratively to enhance performance and ensure complia...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$105K - $120K *

Engage with public health labs to enhance customer satisfaction and drive sales. Collaborate with cross-functional teams to execute market strategies and foster relationships with key opinion leaders...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Unlock potential by leading EHS initiatives across multiple sites, ensuring compliance and safety. Collaborate with operational leaders to mitigate risks, coach teams, and drive continuous improvement...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$126K - $252K *

Lead the charge in advancing risk management and investment strategies through innovative modeling, comprehensive analysis, and collaboration with top investment teams to drive informed decision-makin...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Drive quality assurance for innovative conversational AI solutions, ensuring reliability and accuracy across voice applications and customer engagement platforms. Collaborate with cross-functional tea...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Elevate your career by designing and optimizing EpicCare Ambulatory workflows. Collaborate with clinicians to enhance EHR functionality, troubleshoot issues, and ensure seamless operations across heal...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$97K - $174K *

Empower patient care by providing specialized nursing services in diverse settings. Collaborate with healthcare teams to assess, treat, and educate patients, ensuring high-quality, evidence-based care...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$99K - $120K *

Join a team that's redefining innovation in software engineering for critical facilities. You'll design and deliver cutting-edge applications and data solutions, driving projects from concept to deplo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$113K - $125K *

Drive product strategy and outcomes in a senior role, focusing on educational equity and data-driven impact. Collaborate with cross-functional teams to shape product direction, prioritize initiatives...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Lead the charge in optimizing operational activities within the DHMS program, ensuring compliance and driving continuous improvement. Collaborate with stakeholders to implement effective strategies an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $140K *

Join a dynamic team as you drive sales in the public safety sector, managing a diverse territory. Leverage AI tools to identify opportunities, close deals, and build lasting relationships with agencie...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$95K - $115K *

Optimize implementation processes by leading projects, managing teams, and ensuring client satisfaction. Collaborate cross-functionally to deliver solutions on time and within budget while enhancing o...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Accelerate client success by owning the onboarding and rollout for enterprise clients, ensuring smooth transitions from purchase to sustained usage. Collaborate with cross-functional teams to drive ad...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$135K - $160K *

Lead the strategy for the Commitments product, enhancing customer compliance tracking through AI. Collaborate with cross-functional teams to drive adoption and deliver impactful solutions that address...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Lead the charge in managing complex construction projects, overseeing field operations, ensuring safety and quality, and mentoring junior staff while driving project performance from mobilization to c...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$135K - $160K *

Transform healthcare technology by owning core products, driving architectural decisions, and ensuring high-quality code. Collaborate across teams to deliver impactful solutions that enhance patient c...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Elevate your career by supporting US indirect tax compliance and analysis. Collaborate with cross-functional teams to streamline processes and ensure accurate reporting on multistate tax matters while...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$63K - $111K *

Transform your career by joining a dynamic team as a Security Technician, where you'll travel to install, troubleshoot, and maintain advanced electronic systems, ensuring operational excellence across...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$88K - $115K *

Unlock potential by leading the renewals process, collaborating with cross-functional teams to enhance customer relationships and drive strategic growth opportunities for long-term success...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$62K - $104K *

Unlock potential by designing and implementing behavior intervention plans. Collaborate with IEP teams and staff to foster skill-building and independence for students with behavioral challenges acros...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Drive procurement excellence by managing supplier relationships and optimizing processes. Take ownership of sourcing strategies, ensuring compliance and cost savings while mentoring team members in a...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$125K - $150K *

Empower healthcare practices by serving as a strategic advisor, enhancing financial performance and operational strategies. Lead client relationships and support growth initiatives in a dynamic, entre...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$230K - $290K *

Drive the architecture and strategy for a high-volume telemetry platform, mentoring a team while collaborating across functions to enhance observability practices and ensure system reliability at scal...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.