Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$69K - $119K *

Transform the landscape of clinical documentation by educating and mentoring teams, ensuring compliance, and enhancing documentation accuracy to optimize patient care and coding outcomes...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$133K - $156K *

Accelerate progress at the forefront of AI security operations by engineering innovative, scalable solutions that integrate advanced technologies and enhance cybersecurity capabilities across multiple...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Drive new business generation in captive management solutions, focusing on multifamily risk and large P&C alternatives. Build relationships with brokers and multifamily owners while managing the full...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$82K - $132K *

Unlock potential in revenue cycle management by leading innovative solutions, optimizing processes, and collaborating across departments to enhance operational efficiency and maximize revenue impact...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$64K - $96K *

Lead the charge in delivering exceptional patient care by assessing needs, guiding treatment options, and collaborating with a multi-disciplinary team to ensure high-quality outcomes and continuity of...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Optimize security operations by leading a dynamic team, managing alerts, and enhancing incident response. Collaborate with cross-functional teams to ensure effective detection and operational readines...

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$60K - $120K *

Transform customer experiences through expert automotive sales and relationship building. Drive growth by understanding client needs and delivering tailored solutions, while collaborating with teams t...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$186K - $218K *

Innovate with a collaborative team as you build scalable blockchain infrastructure, design APIs, and streamline complex data processes. Your contributions will enhance system reliability and performan...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$106K - $167K *

Pioneer growth as a Senior Field Sales Executive, driving success in the Eastern US. Manage key accounts, develop strategies, and build relationships to enhance customer satisfaction and achieve sales...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Unlock potential by designing and deploying Power BI solutions that transform data into actionable insights. Collaborate with stakeholders to create scalable models and enhance reporting capabilities...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $185K *

Take ownership of our cloud and backend infrastructure, driving technical direction and improvements. Lead a team to ensure reliability and scalability of systems supporting our games and analytics, w...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$115K - $160K *

Drive your career forward by enabling the Groups team to excel in revenue generation through innovative training, AI-driven tools, and strategic partnerships, ensuring consistent performance and growt...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$200K - $250K *

Elevate the search experience by designing and evolving a robust backend system that powers millions of searches. Collaborate across teams to enhance scalability, reliability, and maintainability whil...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $180K *

Lead organizational capability by bridging strategy and execution across diverse hospitality operations. Drive scalable frameworks and change management to enhance performance and sustain innovation a...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$95K - $125K *

Unlock potential by joining a collaborative team focused on delivering comprehensive primary care. Engage with patients in an outpatient setting, emphasizing preventive care and wellness while working...

1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$302K - $483K *

Transform the future of secure platforms by leading engineering strategy and execution. Drive innovation, operational excellence, and team performance to empower autonomy and accountability across the...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$220K - $310K *

Empower businesses by architecting and deploying innovative AI solutions that leverage graph databases and LLMs. Collaborate with stakeholders to transform complex data challenges into impactful appli...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Unlock potential by designing and building robust data pipelines for healthcare transactions. Collaborate with partners to ensure seamless integration and reliability of data systems, enhancing operat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $140K *

Grow your career with us by leading public safety drone sales in small cities. Own your territory, drive full-cycle deals, and collaborate with cross-functional teams to deliver innovative solutions t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$150K - $180K *

Drive strategic planning and operational excellence for a dynamic Marketing & Communications team. Own budgeting, resource management, and cross-functional partnerships while leading initiatives that...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$78K - $108K *

Empower our growth by managing and negotiating sales contracts, collaborating with cross-functional teams to ensure compliance and efficiency. Your expertise will drive impactful solutions in a dynami...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$125K - $160K *

Join a dynamic team as a Sr. Health Benefit Plan Consulting Attorney, leveraging your expertise in healthcare law to navigate complex regulatory issues, support consulting services, and drive complian...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $90K *

Manage and analyze Lost-Time Workers Compensation claims, ensuring timely resolution and adherence to service expectations. Collaborate with clients and stakeholders to deliver innovative solutions in...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$66K - $102K *

Optimize client solutions by leveraging SAP FICO expertise to analyze, design, and implement financial processes. Collaborate with teams to enhance system functionality and ensure seamless integration...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Take ownership of key client relationships, driving growth in the renewable energy analytics sector while collaborating across teams to support long-term strategic goals and ensure client success with...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.