Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$120K - $145K *

Join a dynamic team to drive the development of a cutting-edge marketplace, enhancing provider products and economic incentives while collaborating closely with engineering and operations to transform...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Lead the design and governance of clinical ontologies and terminology services, ensuring data quality and alignment with product needs. Collaborate cross-functionally to enhance data normalization and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $145K *

Unlock potential by bridging business needs with technical solutions. Collaborate with stakeholders to define requirements, manage product backlogs, and ensure successful delivery of ServiceNow capabi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Lead and inspire a team managing SQL Server databases in cloud and on-prem environments. Oversee project deliverables, budget tracking, and cross-team collaboration to enhance database services for st...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Transform the renewable energy landscape by managing data portfolios, analyzing project performance, and enhancing financial reporting. Collaborate with cross-functional teams to drive strategic energ...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Join a team that's dedicated to providing exceptional clinical care and therapeutic services. You'll treat patients, uphold professional standards, and contribute to a mission-driven environment focus...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$201K - $309K *

Elevate security standards by leading the development of innovative software solutions. Collaborate with cross-functional teams to integrate robust security measures, ensuring the integrity of applica...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Join us to drive strategic relationships with enterprise customers, optimizing IGEL technology solutions. This hands-on role balances technical expertise with customer management, focusing on the Fina...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $200K *

Elevate the People function as a strategic partner, driving talent strategy, organizational design, and culture in a dynamic, global environment. Shape leadership effectiveness and enhance employee ex...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$94K - $157K *

Unlock potential by joining our team as a Data Analyst, where you'll leverage your expertise in data manipulation and visualization to support key Federal clients, driving impactful solutions through...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $185K *

Innovate the future of energy by leading the commissioning of electrical substations. Oversee testing, validation, and project management while collaborating with diverse teams across the nation to en...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $170K *

Shape the future of cloud solutions by architecting and optimizing advanced contact centers. Collaborate with cross-functional teams to leverage AI and AWS technologies, enhancing customer experiences...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Staffing

$73K - $95K *

Advance security measures by monitoring, analyzing, and remediating risks across the enterprise. Collaborate with IT teams to enhance security posture, focusing on threat detection, vulnerability mana...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $140K *

Lead PBM compliance audits, ensuring adherence to state regulations and industry standards. Supervise examiners, manage client relationships, and adapt to a fast-paced environment while driving progra...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Champion operational excellence by leading multi-departmental teams in healthcare services. Drive strategic initiatives, optimize performance, and ensure compliance while enhancing patient satisfactio...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Lead and develop a high-performing team of enterprise account executives, driving revenue growth and shaping sales strategies in the finance sector. Engage with senior decision-makers and manage compl...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock potential by leading tax engagements, mentoring teams, and delivering exceptional client service. Thrive in a collaborative environment while managing multiple projects and driving growth for p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$176K - $220K *

Lead the charge in driving sustainable revenue growth by managing a high-performing team of Account Executives focused on acquiring new clients in the financial sector, ensuring effective sales execut...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Join a team that's shaping the future of DevOps by designing and implementing CI/CD pipelines with cutting-edge technologies. Collaborate with customers and cross-functional teams to enhance their Dev...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Shape your career by leading integrated marketing campaigns that drive customer engagement and new business growth. Collaborate with cross-functional teams to enhance customer adoption and pipeline de...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$88K - $105K *

Champion regional marketing initiatives by aligning with sales to create impactful programs that drive pipeline growth and enhance community engagement. Manage budgets, logistics, and reporting to ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Lead construction project engineering efforts, ensuring compliance with regulations and quality standards. Collaborate with government personnel to oversee project delivery, manage contract administra...

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$68K - $97K *

Lead operational stability and process standardization for transportation across multiple facilities. Collaborate with planners and logistics partners to enhance delivery performance and resolve disru...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Join a dynamic team to design, install, and improve manufacturing equipment and processes, focusing on metal-forming operations. This hands-on role combines engineering expertise with fieldwork to enh...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Join a team that's dedicated to enhancing enterprise IAM governance. You'll oversee access reviews, ensure compliance, and collaborate with cross-functional teams to strengthen security controls and d...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.