Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$100K - $120K *

Shape the future of pharmacy by delivering exceptional patient care, ensuring compliance with regulations, and fostering a positive environment. Drive sales and operational excellence while inspiring...

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$100K - $145K *

Shape the future of technical delivery by leading client engagements, setting standards, and mentoring teams in AI-driven Salesforce solutions, ensuring quality and integration across Marketing Cloud...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$113K - $147K *

Pioneer innovative solutions as a Microsoft Power Platform Architect, leading enterprise-grade design and implementation. Collaborate with stakeholders to enhance efficiency, automate processes, and d...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Shape the future of data protection by leading a high-performing team of analysts. Drive incident response, enhance security strategies, and collaborate with clients to mitigate risks in a fast-paced...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$88K - $105K *

Unlock potential by joining a dynamic team focused on developing innovative software solutions. Collaborate across departments to enhance processes and deliver impactful results for internal teams and...

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$100K - $120K *

Partner with us to shape the future of talent acquisition and employee engagement. Lead strategies that attract, retain, and support exceptional talent while enhancing the employee experience across a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$135K - $160K *

Shape the future of partner marketing by building and executing joint plans with key resellers and distributors, driving engagement and pipeline growth through innovative campaigns and strategic commu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Unlock your potential as a Senior Applied AI Engineer, leading teams to design and deliver impactful AI solutions. Drive technical excellence and mentor engineers while shaping the future of AI system...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Transform healthcare data products by leading strategy, execution, and cross-functional collaboration. Drive product-market fit and commercialization for API-based solutions, ensuring alignment with c...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Accelerate sales growth by leading strategies and initiatives across the ANZ market. Collaborate with a multidisciplinary team to drive customer engagement, develop market strategies, and achieve reve...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Transform procurement operations by leading strategy and team management in a regulated manufacturing environment. Drive supplier performance, cost efficiency, and material availability to support pro...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$78K - $118K *

Develop and optimize a competitive provider network while managing contracts and relationships. Collaborate with stakeholders to ensure alignment with business goals and regulatory standards, driving...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$466K - $500K+*

Unlock potential by developing scalable AI/ML model serving infrastructure. Collaborate cross-functionally to enhance performance and availability of high-traffic systems, driving innovation in a dyna...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$80K - $95K *

Lead the charge in major gifts and planned giving, driving philanthropic revenue through strategic oversight of donor portfolios and team management. Collaborate with stakeholders to enhance fundraisi...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$156K - $215K *

Empower innovation in advanced networking and enterprise solutions by defining strategic roadmaps and driving product lifecycle planning across high-speed networking, optical technologies, and AI plat...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$140K - $185K *

Drive strategic growth by identifying and developing solution-specific opportunities within key accounts, leveraging industry expertise to influence client transformation initiatives and enhance sales...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Transform the Federal landscape by leading enterprise sales efforts, engaging with SES leaders, and driving digital transformation across major accounts. Collaborate with cross-functional teams to ach...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$73K - $98K *

Join a team that's dedicated to excellence in DRG auditing. Leverage your expertise in MS-DRG and APR-DRG coding to ensure accuracy and compliance while working remotely. Enjoy a collaborative environ...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$113K - $198K *

Drive innovation in advanced building systems design, leading projects from concept to completion while mentoring teams and enhancing client relationships. Engage in business development and ensure qu...

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $175K *

Transform operations by leveraging your expertise in IT and cybersecurity. Collaborate with leaders to enhance processes, drive efficiency, and ensure compliance while mentoring teams and aligning str...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$230K - $322K *

Lead the development of machine learning models to enhance advertiser insights, optimizing campaign performance through advanced forecasting and scenario analysis. Collaborate across teams to drive im...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$130K - $160K *

Elevate operational excellence in neurosurgery by leading strategic initiatives, driving performance, and fostering a culture of accountability. Collaborate with executive leaders to enhance patient c...

1 week ago

  •   5 - 7 years exp.  •   Staffing

$165K - $225K *

Champion the development of a GPU-accelerated compute platform, enhancing AI training and research capabilities. Collaborate with cross-functional teams to design orchestration systems that optimize r...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $195K *

Join a team that's redefining account marketing for major clients. Collaborate with cross-functional partners to drive growth, enhance customer engagement, and create tailored marketing strategies tha...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$450K - $475K *

Drive revenue growth by leading a team of Regional Directors, fostering collaboration, and ensuring alignment with company goals. Your leadership will shape the region's success and culture while enha...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.