Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
PHARMACY/PHARMACIST (HR) (118)
$100K - $120K *
Shape the future of pharmacy by delivering exceptional patient care, ensuring compliance with regulations, and fostering a positive environment. Drive sales and operational excellence while inspiring...
1 week ago
$100K - $145K *
Shape the future of technical delivery by leading client engagements, setting standards, and mentoring teams in AI-driven Salesforce solutions, ensuring quality and integration across Marketing Cloud...
1 week ago
Microsoft Power Platform Tech Lead / Architect
$113K - $147K *
Pioneer innovative solutions as a Microsoft Power Platform Architect, leading enterprise-grade design and implementation. Collaborate with stakeholders to enhance efficiency, automate processes, and d...
1 week ago
Manager, Data Protection Analysts (Americas)
$120K - $145K *
Shape the future of data protection by leading a high-performing team of analysts. Drive incident response, enhance security strategies, and collaborate with clients to mitigate risks in a fast-paced...
1 week ago
$88K - $105K *
Unlock potential by joining a dynamic team focused on developing innovative software solutions. Collaborate across departments to enhance processes and deliver impactful results for internal teams and...
1 week ago
Talent Acquisition and Employee Engagement Manager
$100K - $120K *
Partner with us to shape the future of talent acquisition and employee engagement. Lead strategies that attract, retain, and support exceptional talent while enhancing the employee experience across a...
1 week ago
Sr. Manager, Global Channel Partner Marketing
$135K - $160K *
Shape the future of partner marketing by building and executing joint plans with key resellers and distributors, driving engagement and pipeline growth through innovative campaigns and strategic commu...
1 week ago
$150K - $180K *
Unlock your potential as a Senior Applied AI Engineer, leading teams to design and deliver impactful AI solutions. Drive technical excellence and mentor engineers while shaping the future of AI system...
1 week ago
Senior Product Manager (Healthcare Data Products)
$120K - $145K *
Transform healthcare data products by leading strategy, execution, and cross-functional collaboration. Drive product-market fit and commercialization for API-based solutions, ensuring alignment with c...
1 week ago
Sales Manager - Australia/New Zealand Market
$100K - $120K *
Accelerate sales growth by leading strategies and initiatives across the ANZ market. Collaborate with a multidisciplinary team to drive customer engagement, develop market strategies, and achieve reve...
Reposted 1 week ago
$95K - $115K *
Transform procurement operations by leading strategy and team management in a regulated manufacturing environment. Drive supplier performance, cost efficiency, and material availability to support pro...
1 week ago
Provider Network Contract Manager III
$78K - $118K *
Develop and optimize a competitive provider network while managing contracts and relationships. Collaborate with stakeholders to ensure alignment with business goals and regulatory standards, driving...
1 week ago
Software Engineer 4/5 - Model Serving Systems, AI Platform
$466K - $500K+*
Unlock potential by developing scalable AI/ML model serving infrastructure. Collaborate cross-functionally to enhance performance and availability of high-traffic systems, driving innovation in a dyna...
1 week ago
Senior Manager of Major Gifts & Planned Giving
$80K - $95K *
Lead the charge in major gifts and planned giving, driving philanthropic revenue through strategic oversight of donor portfolios and team management. Collaborate with stakeholders to enhance fundraisi...
1 week ago
Director Strategy for Advanced Networking and Enterprise
$156K - $215K *
Empower innovation in advanced networking and enterprise solutions by defining strategic roadmaps and driving product lifecycle planning across high-speed networking, optical technologies, and AI plat...
1 week ago
Strategic Solution Sales Executive
$140K - $185K *
Drive strategic growth by identifying and developing solution-specific opportunities within key accounts, leveraging industry expertise to influence client transformation initiatives and enhance sales...
1 week ago
$150K - $180K *
Transform the Federal landscape by leading enterprise sales efforts, engaging with SES leaders, and driving digital transformation across major accounts. Collaborate with cross-functional teams to ach...
1 week ago
Diagnosis-Related Group (DRG) Auditor III
$73K - $98K *
Join a team that's dedicated to excellence in DRG auditing. Leverage your expertise in MS-DRG and APR-DRG coding to ensure accuracy and compliance while working remotely. Enjoy a collaborative environ...
1 week ago
$113K - $198K *
Drive innovation in advanced building systems design, leading projects from concept to completion while mentoring teams and enhancing client relationships. Engage in business development and ensure qu...
1 week ago
IT Subject Matter Expert (SME)
$100K - $175K *
Transform operations by leveraging your expertise in IT and cybersecurity. Collaborate with leaders to enhance processes, drive efficiency, and ensure compliance while mentoring teams and aligning str...
Reposted 1 week ago
Staff Machine Learning Engineer, Ads Forecasting & Scenarios
$230K - $322K *
Lead the development of machine learning models to enhance advertiser insights, optimizing campaign performance through advanced forecasting and scenario analysis. Collaborate across teams to drive im...
1 week ago
Vice President Operations - Neurosurgery
$130K - $160K *
Elevate operational excellence in neurosurgery by leading strategic initiatives, driving performance, and fostering a culture of accountability. Collaborate with executive leaders to enhance patient c...
1 week ago
Senior Software Engineer, Compute Platform
$165K - $225K *
Champion the development of a GPU-accelerated compute platform, enhancing AI training and research capabilities. Collaborate with cross-functional teams to design orchestration systems that optimize r...
1 week ago
Senior Strategic Marketing Manager | East Coast | Remote
$160K - $195K *
Join a team that's redefining account marketing for major clients. Collaborate with cross-functional partners to drive growth, enhance customer engagement, and create tailored marketing strategies tha...
1 week ago
Regional Vice President, Central | Remote |
$450K - $475K *
Drive revenue growth by leading a team of Regional Directors, fostering collaboration, and ensuring alignment with company goals. Your leadership will shape the region's success and culture while enha...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.