Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Product Manager, Property Intelligence
$95K - $158K *
Transform the Property Intelligence platform by connecting customer needs with product insights. Collaborate across teams to enhance product adoption and engagement through analytics and feedback, dri...
1 week ago
Sr. Site Reliability Engineer (SRE)
$165K - $225K *
Unlock your potential by designing and operating robust Kubernetes infrastructure. Collaborate with cross-functional teams to ensure high-performance, reliable systems that support enterprise-scale AI...
1 week ago
SAP Basis Administrator - Onsite in St. Louis, MO
$91K - $246K *
Drive the administration and optimization of SAP Basis and HANA systems. Collaborate with teams to troubleshoot issues, manage backups, and support deployments while mentoring junior staff and ensurin...
1 week ago
Growth Marketing Manager, AI & Paid Programs
$110K - $130K *
Innovate demand generation strategies by managing paid media, automating workflows, and leveraging AI tools. Collaborate with teams to enhance pipeline efficiency and drive measurable results through...
1 week ago
Sr Director of Customer Operations & Delivery
$200K - $230K *
Lead customer success initiatives by managing federal program delivery, ensuring seamless deployment, support, and renewal processes. Drive team performance and build strategic partnerships to enhance...
1 week ago
AI Infrastructure Engineer [Tooling]
$130K - $160K *
Empower AI innovation by designing and building robust tooling for deploying AI agents in production. Collaborate with cross-functional teams to enhance infrastructure reliability and developer experi...
1 week ago
$132K - $170K *
Shape the future of client relationships by driving retention and growth through strategic account management and consultative sales, engaging with C-level executives to maximize value and expand serv...
1 week ago
$150K - $180K *
Shape and execute a comprehensive partnership strategy to drive growth, enhance market presence, and foster high-value alliances across the healthcare ecosystem, collaborating with executive leadershi...
1 week ago
$80K - $100K *
Engage with communities by driving customer acquisition through door-to-door sales in multi-dwelling units. Utilize a consultative approach to meet sales targets while enhancing customer experiences a...
1 week ago
$110K - $130K *
Champion transformative initiatives by translating priorities into actionable plans, coordinating cross-functional teams, and driving organizational change to enhance operational effectiveness and ado...
1 week ago
Key Account Leader, Mid Cities East
$110K - $140K *
Lead the charge in driving sales for mid-sized public safety agencies, managing full-cycle deals from opportunity identification to closing. Collaborate with cross-functional teams to ensure successfu...
1 week ago
$106K - $167K *
Join us to analyze and optimize complex business processes, design ERP solutions, and lead integration efforts. Collaborate with teams to enhance performance and ensure compliance while delivering hig...
Reposted 1 week ago
$160K - $190K *
Pioneer innovative AI solutions to transform biomedical discovery, collaborating with top scientists and engineers to bridge virtual and real-world data, enhancing drug discovery and clinical care pro...
1 week ago
Clinical Applications Specialist
$80K - $95K *
Help us deliver exceptional training and support for medical imaging equipment, enhancing customer experiences through expertise and mentorship while traveling frequently to engage with healthcare pro...
1 week ago
$73K - $102K *
Join a team that's transforming ERP solutions by customizing and integrating systems to meet business needs. Collaborate with stakeholders to enhance performance and ensure compliance while delivering...
1 week ago
$110K - $130K *
Drive AI-powered marketing initiatives to optimize campaigns, enhance pipeline generation, and leverage automation. Collaborate cross-functionally while experimenting with emerging technologies to red...
1 week ago
$110K - $130K *
Elevate security operations by leading a dynamic team in monitoring, incident response, and continuous improvement. Drive strategic initiatives and enhance organizational resilience against emerging t...
1 week ago
$95K - $115K *
Drive strategic transformation by leading a team of Business Analysts, fostering strong partnerships with stakeholders, and evolving the BA function into an embedded model that enhances organizational...
1 week ago
Mission Integration Lead - Survivable Airborne Operations
$130K - $150K *
Unlock potential by leading the design and integration of secure, resilient network architectures for mission-critical systems, ensuring operational performance and recovery objectives are met through...
1 week ago
Territory Sales Manager (IOWA)
$97K - $151K *
Lead the growth of agency relationships to enhance profitability in your territory. Oversee the execution of strategic initiatives, manage agent performance, and deliver training to drive success in G...
1 week ago
Entry-Level Geotechnical Engineer (EIT)
$79K - $86K *
Contribute to innovative geotechnical projects by performing analyses, designing foundations, and collaborating with multidisciplinary teams to ensure successful project execution and community impact...
1 week ago
$92K - $153K *
Join a team that's dedicated to enhancing patient access by managing reimbursement challenges and providing education to healthcare providers. This role requires strong relationship-building skills an...
1 week ago
Senior Frontend Engineer, Ads Formats
$190K - $267K *
Drive impactful ad experiences by leveraging your frontend expertise in JavaScript and TypeScript. Collaborate with cross-functional teams to enhance user engagement and optimize ad performance across...
1 week ago
Manager, Corporate Communications - Software
$81K - $128K *
Unlock potential by shaping integrated corporate communications strategies that connect software innovation with community impact, bridging B2B and B2C narratives to advance fraud prevention and eleva...
Reposted 1 week ago
Senior Director of Engineering
$261K - $308K *
Transform Women's Health engineering by leading a high-impact team to deliver innovative software solutions. Collaborate across functions to shape strategy and drive organizational excellence while en...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.