Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$232K - $320K *

Unlock potential by leading a dynamic Solutions Consulting team to deliver innovative cybersecurity solutions. Collaborate with sales and customers to ensure value realization and drive success in pre...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$77K - $176K *

Innovate IT operations by leveraging AI to enhance national security. As a key contributor, you'll automate workflows, develop AI agents, and streamline processes, ensuring efficient delivery of criti...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Empower your career by leading the Information Assurance program for critical Army systems. Oversee compliance, manage security processes, and collaborate with stakeholders to ensure robust cybersecur...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$69K - $104K *

Unlock your potential by collaborating with leaders to enhance payor performance, streamline revenue cycle operations, and drive innovation in healthcare. Your expertise will ensure impactful engageme...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$99K - $232K *

Unlock operational excellence by optimizing efficiency and effectiveness across product development lifecycles. Collaborate with clients to reduce costs, improve quality, and implement lean manufactur...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$99K - $232K *

Lead the charge in optimizing operational efficiency by utilizing lean principles and digital innovation, while coaching teams to enhance product development cycles and achieve client satisfaction at...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$125K - $150K *

Drive technical solutions as a client-facing architect, leveraging deep expertise in JavaScript, TypeScript, and Python to guide enterprise-level projects across multiple cloud environments and enhanc...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$88K - $105K *

Champion project success by leading controls activities for facility projects, aligning schedules, and ensuring compliance with scope and standards to optimize capital project execution across the org...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$80K - $100K *

Engage with prospective customers by providing tailored telecommunication solutions. Drive sales growth through face-to-face interactions, conducting needs analyses, and presenting compelling proposal...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock your potential by leading project procurement efforts, optimizing processes, and managing supplier relationships to enhance operational efficiency and profitability across diverse project categ...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$120K - $160K *

Join a team that's redefining integrated marketing strategies, leading cross-channel campaigns that drive product narratives and customer engagement. Shape the future of marketing through collaboratio...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Champion integrated psychological services for transplant patients, conducting evaluations and delivering therapy across inpatient and outpatient settings. Collaborate with multidisciplinary teams to...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $123K *

Grow your career with a dynamic role focused on building client relationships, identifying business opportunities, and driving sales growth through innovative technology solutions in a collaborative e...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in enhancing branch performance through innovative learning strategies. Collaborate with stakeholders to identify gaps, develop solutions, and drive adoption of new skills, ensuring te...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$124K - $224K *

Unlock potential by leading revenue operations, bridging sales, finance, and analytics. Drive forecasting, pipeline management, and team development to enhance business performance and ensure data int...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$151K - $248K *

Unlock your potential by driving product innovation and cross-functional alignment in a dynamic environment. Lead initiatives that shape lending solutions, enhance decision-making, and deliver impactf...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$75K - $105K *

Champion project success by collaborating with teams to develop technical strategies, manage client communications, and ensure profitable project execution across diverse industrial applications...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$119K - $180K *

Optimize SAP environments by administering, monitoring, and supporting SAP S/4HANA and related technologies. Collaborate with cross-functional teams to ensure a secure, high-performing system that mee...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Champion your career by leading security engagements, assessing architectures, and enhancing compliance. Collaborate with top professionals to identify risks and implement best practices, ensuring rob...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$139K - $235K *

Transform compensation strategies by leading program design and execution. Collaborate with cross-functional teams to ensure compliance, enhance processes, and deliver accurate outcomes that attract a...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$300K - $350K *

Join a team that's driving sales growth in the cybersecurity sector. This role focuses on acquiring new accounts, building customer relationships, and ensuring satisfaction while exceeding sales quota...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Join a team that's dedicated to enhancing information security through proactive assessments and innovative solutions. Contribute to compliance and risk management while implementing best practices in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$276K - $380K *

Drive the information security strategy for System IT Ops and Policy, ensuring effective collaboration across teams to protect assets and enhance cybersecurity practices while achieving measurable bus...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$276K - $380K *

Empower your career by leading the information security strategy for District IT & Corporate Services. Collaborate with stakeholders to ensure secure, resilient technology solutions while driving meas...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$276K - $380K *

Optimize information security across System IT Ops and Policy portfolios. Collaborate with stakeholders to develop strategies that enhance cybersecurity resilience and ensure secure, reliable technolo...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.