Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$125K - $295K *

Lead the charge in optimizing global delivery operations, ensuring seamless hub economics and resource allocation. Collaborate with finance and commercial teams to drive data-driven decisions and main...

Reposted today

  •   Less than 5 years exp.  •   Media

$115K - $140K *

Join a team that's dedicated to transforming patient engagement through innovative marketing strategies. You'll develop and execute multichannel campaigns, crafting compelling content that drives enro...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Support the oncology care journey by delivering high-quality virtual patient care, coordinating services, and providing clinical support while building strong relationships with patients and clinical...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Transform your career by leading the design and implementation of Pega applications. Collaborate with dynamic teams to deliver innovative BPM/BRE solutions, leveraging your expertise in system archite...

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$95K - $143K *

Champion compassionate care by assessing patient needs and managing symptoms in a collaborative hospice team. Engage with families to enhance quality of life during end-of-life care, ensuring dignity...

Today

  •   Less than 5 years exp.  •   Healthcare

$295K - $312K *

Join a team that's shaping the future of drug safety! Provide operational leadership across pharmacovigilance functions, oversee compliance and vendor relationships, and ensure high-quality safety rep...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $198K *

Join us in overseeing end-to-end clinical supply management for global studies, focusing on demand planning, global distribution, and cross-functional leadership to ensure compliant and cost-effective...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform application deployment by collaborating with teams to streamline processes, enhance automation, and ensure high-quality releases across environments while mentoring junior members and drivin...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Partner with us to drive financial success in construction projects by managing budgets, forecasts, and reporting. Collaborate with teams to ensure timely completion and profitability while identifyin...

Today

  •   Less than 5 years exp.  •   Real Estate & Construction

$84K - $155K *

Elevate your career by supporting strategic contract administration for government services. Collaborate with cross-functional teams to ensure compliance and manage complex contractual obligations whi...

Reposted today

  •   5 - 7 years exp.  •   Business Services

$156K - $275K *

Lead the charge in shaping the technical strategy for reliability and infrastructure. Drive initiatives across teams, design scalable systems, and enhance operational excellence while mentoring engine...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$84K - $155K *

Lead impactful contract administration activities, ensuring compliance and collaboration in the execution of government contracts to support strategic objectives and maintain operational efficiency wi...

Reposted today

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Unlock potential by leading strategic initiatives for a portfolio of Department of War customers. Drive growth, foster executive relationships, and ensure impactful operational outcomes while guiding...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Transform initiatives through expert project management, elevating communication and cross-team coordination to ensure operational excellence and drive strategic goals...

Reposted today

  •   Less than 5 years exp.  •   Business Services

$90K - $120K *

Transform customer experiences by leading a dynamic Policy Operations team, driving process innovation, and collaborating with cross-functional partners to enhance service delivery and operational eff...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Drive impactful projects forward, align stakeholders, and enhance operational efficiency. Collaborate across teams to manage priorities and deliver precise communications in a fast-paced environment...

Reposted today

  •   Less than 5 years exp.  •   Business Services

$255K - $295K *

Lead the technical direction for foundational services, guiding architecture and execution across teams to enhance platform capabilities for customer and partner experiences. Mentor engineers and infl...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Explore new business opportunities and build lasting client relationships. Drive the full sales cycle, from prospecting to closing, while collaborating with cross-functional teams to deliver tailored...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$95K - $115K *

Champion women's health by providing comprehensive prenatal and gynecologic care in a supportive, collaborative environment. Enjoy a four-day work week with no hospital responsibilities, fostering pro...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$73K - $115K *

Launch your engineering career by tackling real manufacturing challenges. Engage in a three-year rotational program that fosters growth through mentorship, diverse experiences, and exposure to industr...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Business Services

$90K - $110K *

Lead the charge in resolving complex technical issues, enhancing support processes, and collaborating with engineering teams to improve product functionality and customer satisfaction in a dynamic B2B...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Unlock potential by leading clinical excellence in a supportive environment, leveraging advanced technology and a dedicated team to provide exceptional patient care while maintaining clinical autonomy...

Reposted today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$235K - $270K *

Unlock potential by leading actuarial strategy and health economic analyses. Collaborate with cross-functional teams to enhance value propositions and drive commercial growth while translating complex...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$200K - $225K *

Transform healthcare data into actionable insights by leading actuarial strategy and health economic analyses. Collaborate with cross-functional teams to enhance value propositions and drive commercia...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$162K - $203K *

Drive impactful market research initiatives by collaborating with cross-functional teams to translate business needs into actionable insights, ensuring high-quality execution and strategic decision-ma...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.