Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $100K *

Join us to drive rapid sales cycles and new customer acquisition in a dynamic, metrics-driven environment. You'll manage a robust pipeline, engage key stakeholders, and leverage digital tools to achie...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $125K *

Take ownership of client relationships by guiding enterprise clients through technical integrations and offering strategic insights. Leverage your expertise in digital marketing to enhance client succ...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Media

$135K - $160K *

Champion provider partnerships by leading a dynamic team to drive referrals for interventional treatments across multiple states. Utilize data-driven strategies to enhance performance and build impact...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$108K - $130K *

Unlock the potential of facilities engineering by leading resilience programs, setting global standards, and providing technical support across a vast manufacturing network. Drive innovation and ensur...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$80K - $95K *

Lead full-cycle recruiting for diverse roles in logistics and freight. Optimize hiring strategies, build talent pipelines, and enhance candidate experiences while collaborating with hiring managers to...

1 week ago

  •   Less than 5 years exp.  •   Transportation

$94K - $157K *

Unlock your potential as a Senior Software Developer, designing and integrating critical applications for national security. Collaborate cross-functionally while leveraging your expertise in software...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $140K *

Engage with stakeholders to define and execute innovative marketing strategies for IoT solutions. Drive awareness and demand generation across diverse channels, ensuring alignment with global initiati...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$192K - $202K *

Lead the charge in architecting and integrating complex systems for a scalable retail platform. Drive multi-quarter projects, collaborate across teams, and mentor junior engineers while ensuring high...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$203K - $214K *

Empower your creativity by joining a mission-driven team that designs impactful customer experiences through innovative strategies and exceptional design. Drive growth initiatives and craft engaging j...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$158K - $199K *

Empower innovation in ad formats by leading cross-functional teams to create engaging user experiences. Drive growth for new advertisers while managing strategic partnerships and executing impactful p...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$170K - $179K *

Transform customer success by leading a high-performing team, driving satisfaction and retention in a fast-paced SaaS environment. Collaborate across functions to enhance customer strategies and deliv...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Consumer Technology

$128K - $135K *

Drive impactful insights by transforming data into strategic decisions that enhance retail partnerships. Collaborate with key stakeholders to deliver analytics that support growth and optimize perform...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$87K - $253K *

Lead the charge in enhancing SOC capabilities to combat AI-driven threats. Collaborate with senior stakeholders, develop modernization strategies, and mentor teams to deliver cutting-edge security sol...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$158K - $199K *

Lead the charge in driving the Carrot Ads platform, impacting strategic growth through collaboration across engineering, product, and external partnerships. Shape product direction while enhancing par...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$84K - $126K *

Transform the HR landscape by leading a dynamic team to enhance associate experiences, drive strategic initiatives, and ensure compliance while fostering a culture of belonging and development within...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Join a dynamic team as a Virtual Desktop Infrastructure Engineer, where you'll design and implement secure communication solutions for classified environments, ensuring compliance with DoD cybersecuri...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$90K - $130K *

Drive sales growth in the Midwest by managing customer relationships, developing strategies, and coordinating sales activities. Collaborate with teams to ensure customer satisfaction and achieve terri...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$151K - $309K *

Lead the charge in transforming care agent tools, enhancing system reliability and performance. Collaborate with cross-functional teams to design and implement solutions that streamline support proces...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$190K - $304K *

Drive operational excellence in managing merchant liens and levies compliance. Build a specialized team, establish governance frameworks, and ensure effective collaboration across departments to creat...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$114K - $145K *

Shape your career as a Data Engineer, transforming raw data into impactful systems. Collaborate with stakeholders, optimize data architecture, and drive efficiency through automation while managing co...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$193K - $309K *

Innovate by leading the development of scalable features for our Sports & Entertainment platform. Collaborate across teams to enhance customer experiences and drive Toast's success while mentoring fel...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$70K - $110K *

Champion the implementation and support of Windows Server environments, ensuring optimal performance and security across diverse customer infrastructures while collaborating with technical teams and s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$127K - $159K *

Drive statistical leadership in oncology clinical development, guiding study design, analysis, and regulatory submissions. Collaborate with cross-functional teams to ensure high-quality deliverables a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Drive innovative strategies in generative engine optimization, leading client accounts and teams to enhance visibility and authority in AI-driven search landscapes while ensuring measurable outcomes a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Advance healthcare solutions by developing scalable ML systems, collaborating with cross-functional teams, and driving innovative AI methodologies to enhance patient outcomes and optimize operational...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.