Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$100K - $120K *
Lead the charge in developing client relationships and driving new business opportunities in the Life Sciences sector. Utilize a consultative sales approach to create bespoke marketing campaigns and m...
1 week ago
$90K - $115K *
Unlock potential by leveraging your pharmacy expertise to drive client growth and retention. Collaborate with teams to provide consultative support and insights in pharmacy and medical policy, enhanci...
1 week ago
Director, Franchise Operations - Total Portfolio, NorCal MU
$145K - $169K *
Transform the Coca-Cola business by managing bottler partnerships, driving strategic planning, and ensuring operational excellence. Lead initiatives that enhance franchise capabilities and foster sust...
1 week ago
Account Executive - In-Territory (San Diego, CA)
$91K - $110K *
The Account Executive in San Diego is responsible for managing the full sales cycle, including prospecting, building relationships, and closing deals. This role requires a proactive approach to expand...
Reposted 1 week ago
$100K - $120K *
Shape the future of our Bike category by driving merchandising strategy, managing vendor relationships, and mentoring a dynamic team. Own the budget and make impactful decisions to enhance financial p...
1 week ago
$56K - $125K *
Unlock potential by leading store operations, enhancing customer experiences, and driving sales growth. Oversee team performance, manage inventory, and ensure compliance while fostering a positive wor...
1 week ago
Group Director, Consumer Services
$150K - $180K *
Join a dynamic team as a senior leader, driving client relationships and revenue growth in lead-generation sectors. You'll manage a diverse portfolio, ensuring lead quality and speed while leveraging...
Reposted 1 week ago
$110K - $130K *
Champion the development of AI-driven products, leading strategic initiatives and execution. Drive product roadmaps, manage budgets, and ensure alignment with business goals while delivering impactful...
1 week ago
$105K - $245K *
Lead the charge in developing and empowering a high-performing sales team. Foster a strong team culture while driving improvement and accountability in a rapidly changing environment, leveraging data...
Reposted 1 week ago
Senior Director, Client Sales & Insights
$100K - $130K *
Drive commercial activation and revenue growth for a multi-million-dollar portfolio, leveraging strategic insights and AI to enhance client engagement and decision-making. Lead cross-functional teams...
1 week ago
Digital Manufacturing Consultant (MES, Digital Automation, Digital Twin) Senior Associate
$77K - $202K *
Empower clients by analyzing digital manufacturing needs and enhancing production performance through MES, automation, and digital twin solutions. Collaborate with teams to deliver actionable insights...
1 week ago
Digital Manufacturing Consultant (MES, Digital Automation, Digital Twin) Senior Associate
$77K - $202K *
Drive digital transformation in manufacturing by analyzing complex problems, managing workstreams, and enhancing client relationships. Collaborate on MES, automation, and digital twin initiatives to o...
1 week ago
Senior QA Automation Engineer - SDET
$100K - $120K *
Drive quality assurance as a Senior QA Automation Engineer, enhancing our distributed database platform through designing automated tests, validating features, and improving release processes while wo...
Reposted 1 week ago
Preconstruction Director - Power Generation
$125K - $150K *
Shape the future of preconstruction services by leading teams in cost analysis, estimate development, and project strategy for industrial power projects. Collaborate with stakeholders to ensure succes...
1 week ago
Data Architect [ Must Have EPIC Caboodle $ Population Health ]
$110K - $130K *
Engineer innovative data solutions to optimize population health, enhance quality care analytics and reporting, while ensuring data governance and compliance within the healthcare domain. Collaborate...
Reposted 1 week ago
$75K - $127K *
Transform software solutions by developing, analyzing, and optimizing applications. Collaborate with teams to enhance operational efficiency and deliver innovative technology for diverse industries in...
1 week ago
$62K - $103K *
Drive open-source research and analysis to support high-profile government clients. Conduct media monitoring, identify trends, and prepare concise reports to inform decision-making, all while working...
Reposted 1 week ago
$75K - $90K *
Engage with borrowers and partners to drive loan origination success. Build relationships, manage a robust pipeline, and consistently meet targets while navigating the lending landscape to deliver tai...
1 week ago
Senior Applied Scientist II, Ads Optimization
$240K - $253K *
Pioneer innovation in real-time bid optimization systems, driving advertising performance by turning complex mathematical insights into robust production code. Lead cross-functional initiatives to max...
Reposted 1 week ago
Director of Product, Logistics
$291K - $307K *
Innovate as you lead the Logistics product organization, shaping strategy and vision for sustainable growth while driving efficiencies that enhance the marketplace experience for customers, shoppers...
Reposted 1 week ago
$231K - $244K *
Champion privacy initiatives by integrating compliance across product, engineering, and advertising teams. Ensure data protection measures are practical and actionable, positioning the organization as...
Reposted 1 week ago
$149K - $157K *
Empower leaders by shaping talent strategies that connect business goals to people decisions. As a trusted advisor, drive organizational health and development while enhancing performance in a high-gr...
Reposted 1 week ago
Mid Market Account Executive, Toast Retail
$98K - $157K *
Join us to source and close multi-location retail deals, building a new sales strategy for complex accounts. You'll navigate buyer dynamics, drive value-based selling, and collaborate with cross-funct...
Reposted 1 week ago
Senior Director, Supply Chain Finance
$150K - $180K *
Transform our financial operations by leading supply chain finance initiatives, delivering actionable insights and fostering partnerships to enhance profitability and drive value creation across diver...
Reposted 1 week ago
$95K - $115K *
Manage injection molding processes and quality across multiple value streams in a 24/7 operation. Lead teams with data-driven insights, ensuring validated processes and high performance while fosterin...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.