Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$100K - $120K *

Lead the charge in developing client relationships and driving new business opportunities in the Life Sciences sector. Utilize a consultative sales approach to create bespoke marketing campaigns and m...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $115K *

Unlock potential by leveraging your pharmacy expertise to drive client growth and retention. Collaborate with teams to provide consultative support and insights in pharmacy and medical policy, enhanci...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$145K - $169K *

Transform the Coca-Cola business by managing bottler partnerships, driving strategic planning, and ensuring operational excellence. Lead initiatives that enhance franchise capabilities and foster sust...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$91K - $110K *

The Account Executive in San Diego is responsible for managing the full sales cycle, including prospecting, building relationships, and closing deals. This role requires a proactive approach to expand...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Shape the future of our Bike category by driving merchandising strategy, managing vendor relationships, and mentoring a dynamic team. Own the budget and make impactful decisions to enhance financial p...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$56K - $125K *

Unlock potential by leading store operations, enhancing customer experiences, and driving sales growth. Oversee team performance, manage inventory, and ensure compliance while fostering a positive wor...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Join a dynamic team as a senior leader, driving client relationships and revenue growth in lead-generation sectors. You'll manage a diverse portfolio, ensuring lead quality and speed while leveraging...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Champion the development of AI-driven products, leading strategic initiatives and execution. Drive product roadmaps, manage budgets, and ensure alignment with business goals while delivering impactful...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $245K *

Lead the charge in developing and empowering a high-performing sales team. Foster a strong team culture while driving improvement and accountability in a rapidly changing environment, leveraging data...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$100K - $130K *

Drive commercial activation and revenue growth for a multi-million-dollar portfolio, leveraging strategic insights and AI to enhance client engagement and decision-making. Lead cross-functional teams...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$77K - $202K *

Empower clients by analyzing digital manufacturing needs and enhancing production performance through MES, automation, and digital twin solutions. Collaborate with teams to deliver actionable insights...

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$77K - $202K *

Drive digital transformation in manufacturing by analyzing complex problems, managing workstreams, and enhancing client relationships. Collaborate on MES, automation, and digital twin initiatives to o...

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$100K - $120K *

Drive quality assurance as a Senior QA Automation Engineer, enhancing our distributed database platform through designing automated tests, validating features, and improving release processes while wo...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Shape the future of preconstruction services by leading teams in cost analysis, estimate development, and project strategy for industrial power projects. Collaborate with stakeholders to ensure succes...

1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$110K - $130K *

Engineer innovative data solutions to optimize population health, enhance quality care analytics and reporting, while ensuring data governance and compliance within the healthcare domain. Collaborate...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$75K - $127K *

Transform software solutions by developing, analyzing, and optimizing applications. Collaborate with teams to enhance operational efficiency and deliver innovative technology for diverse industries in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$62K - $103K *

Drive open-source research and analysis to support high-profile government clients. Conduct media monitoring, identify trends, and prepare concise reports to inform decision-making, all while working...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $90K *

Engage with borrowers and partners to drive loan origination success. Build relationships, manage a robust pipeline, and consistently meet targets while navigating the lending landscape to deliver tai...

Springfield, MORemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$240K - $253K *

Pioneer innovation in real-time bid optimization systems, driving advertising performance by turning complex mathematical insights into robust production code. Lead cross-functional initiatives to max...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$291K - $307K *

Innovate as you lead the Logistics product organization, shaping strategy and vision for sustainable growth while driving efficiencies that enhance the marketplace experience for customers, shoppers...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$231K - $244K *

Champion privacy initiatives by integrating compliance across product, engineering, and advertising teams. Ensure data protection measures are practical and actionable, positioning the organization as...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$149K - $157K *

Empower leaders by shaping talent strategies that connect business goals to people decisions. As a trusted advisor, drive organizational health and development while enhancing performance in a high-gr...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$98K - $157K *

Join us to source and close multi-location retail deals, building a new sales strategy for complex accounts. You'll navigate buyer dynamics, drive value-based selling, and collaborate with cross-funct...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Transform our financial operations by leading supply chain finance initiatives, delivering actionable insights and fostering partnerships to enhance profitability and drive value creation across diver...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$95K - $115K *

Manage injection molding processes and quality across multiple value streams in a 24/7 operation. Lead teams with data-driven insights, ensuring validated processes and high performance while fosterin...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.