Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$130K - $171K *

Lead the charge in building and executing a comprehensive commissioning program for Modular Data Centers, ensuring optimal performance from factory testing to operational handover while collaborating...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$78K - $118K *

Join a team that's dedicated to enhancing Medicare Advantage products. You'll lead material reviews, ensure compliance, support operational readiness, and conduct competitor analysis to drive strategi...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Drive strategic initiatives and operational excellence by partnering with leadership to translate priorities into actionable plans, fostering alignment, and enhancing decision-making across U.S. & Can...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $140K *

Develop and execute strategic business initiatives, cultivating partnerships and driving revenue growth through market analysis and relationship management. Collaborate with cross-functional teams to...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$193K - $309K *

Lead the charge in delivering impactful GTM solutions by managing a skilled engineering team, overseeing technical operations, and fostering collaboration with stakeholders to drive innovation and qua...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$86K - $176K *

Unlock potential by leveraging data science to drive strategic insights and performance across sales and finance. Collaborate with teams to enhance decision-making through advanced analytics, machine...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $200K *

Pioneer capital relationships across M&A and investment vehicles. Drive fundraising efforts and educate investors on private markets. Build a wealth channel from the ground up while collaborating with...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$70K - $97K *

Elevate your career by driving sales and fostering customer relationships in a dynamic environment. Collaborate with cross-functional teams to introduce innovative products and achieve long-term growt...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$159K - $235K *

Optimize security infrastructure by designing and implementing robust access management and secrets storage solutions, ensuring seamless integration and operational excellence across engineering teams...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$122K - $169K *

Transform the future of home equity lending by driving partnerships with mortgage banks and brokers. Leverage your sales expertise to expand our TPO business, enhance brand presence, and collaborate w...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$88K - $105K *

Help us build lasting customer relationships by diagnosing needs and advocating for solutions. Leverage your expertise in a dynamic environment to drive product adoption and contribute to strategic re...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$84K - $124K *

Optimize advanced material planning activities across customer projects, ensuring procurement readiness and risk identification while facilitating seamless transitions from planning to purchasing exec...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$250K - $300K *

Advance your career by providing exceptional oral surgery care in a supportive, tech-driven practice. Collaborate with a skilled team and enjoy a strong referral base, modern facilities, and ample opp...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Shape product strategy and execution for startup products by leveraging user insights, market analysis, and cross-functional collaboration to drive impactful recommendations and clear roadmaps for fou...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$84K - $142K *

Join a dynamic team to lead project implementations, manage budgets, and drive customer success. Collaborate with cross-functional experts to deliver impactful solutions for federal clients, enhancing...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $160K *

Lead strategic banking initiatives by leveraging your enterprise sales expertise to build relationships and drive new business within Tier 1 global banks, shaping our go-to-market strategy and establi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$94K - $148K *

Join a team that's redefining technology sourcing strategies to drive savings and innovation. Lead cross-functional collaboration, manage supplier performance, and coach a talented team to optimize te...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Unlock potential by leading the SMB acquisition lifecycle, driving growth through innovative strategies and digital sales leadership. Collaborate with cross-functional teams to optimize customer engag...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Join a team that's dedicated to optimizing hospital technology systems, ensuring reliable operations and support for clinical and business functions while leading troubleshooting efforts and driving c...

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$90K - $105K *

Champion customer success by providing technical expertise and training in histology applications. Collaborate with sales and service teams to optimize workflows and enhance instrument utilization acr...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$320K - $405K *

Design and oversee the electrical architecture for cutting-edge data centers, ensuring robust power distribution and integration of advanced technologies. Collaborate with partners to enhance prefabri...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $190K *

Accelerate progress at senior living communities by leading a high-performing Customer Success team, ensuring measurable outcomes and fostering strong partnerships to enhance care delivery and custome...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Champion operational excellence in psychiatric care by leading a dynamic team focused on quality, compliance, and innovation. Drive improvements in provider operations and enhance mental healthcare de...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Elevate your career by engaging with clients to design and implement innovative technical solutions. Leverage your expertise in APIs and customer collaboration to drive impactful results in a fast-pac...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$129K - $210K *

Transform issue management by leading a team to develop AI-assisted solutions, ensuring quality and accountability in remediation processes across GRC. Drive engineering excellence while fostering ind...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.