Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$144K - $184K *

Transform strategic accounts by driving sales and fostering executive relationships. Leverage deep industry knowledge to identify opportunities and enhance client satisfaction, ensuring growth and ret...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Business Services

$100K - $120K *

Shape the future of food solutions by managing product lines to drive growth, optimize profitability, and align market opportunities with operational capabilities through strategic initiatives and cro...

6 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$102K - $127K *

Engineer modernization projects with a customer-focused approach, ensuring efficient delivery and high-quality installations. Collaborate with superintendents and management to meet deadlines and enha...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Elevate project outcomes by overseeing mechanical engineering tasks, coordinating design efforts, and ensuring compliance with standards. Drive efficiency through detailed evaluations and mentorship w...

6 days ago

  •   Less than 5 years exp.  •   Technical Services

$100K - $130K *

Transform patient care by delivering comprehensive primary services in home settings. Collaborate with interdisciplinary teams to enhance health outcomes for seniors and individuals with complex needs...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$116K - $150K *

Champion innovative SAP FICA solutions, guiding clients through implementation and configuration while ensuring alignment with business needs and budgetary constraints. Drive value-added consulting to...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Transform the quality landscape of data center equipment by overseeing supplier audits, inspections, and continuous improvement initiatives. Collaborate with cross-functional teams to ensure complianc...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$114K - $124K *

Unlock potential by joining a collaborative dental team focused on patient care and professional growth. Enjoy flexible scheduling, competitive pay, and a supportive environment that welcomes both exp...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Transform sales operations by leading deal desk activities, guiding reps on deal structuring, and driving data analysis for revenue forecasting. Collaborate with finance and sales leadership to ensure...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $100K *

Join a team that's dedicated to delivering high-quality, patient-centered care in Interventional Radiology. Collaborate with healthcare professionals to evaluate patients, perform procedures, and supp...

6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$200K - $250K *

Champion the growth of Spine product sales across the Midwest and North Central regions. Lead training initiatives, manage agency performance, and drive strategic sales efforts to enhance market prese...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $80K *

Serve as a key resource in infection prevention, utilizing clinical expertise to enhance patient outcomes through data analysis, education, and performance improvement initiatives within the healthcar...

6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $150K *

Inspire excellence in healthcare project delivery by leading a dynamic team, ensuring compliance, and driving innovation. Oversee strategic initiatives, manage client relationships, and foster a cultu...

Reposted 6 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Unlock potential by leading bioanalytical projects, designing assays, managing teams, and ensuring quality compliance. You will drive drug development through scientific expertise in bioanalytical met...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$72K - $121K *

Shape the future of talent acquisition by managing full-cycle recruiting, collaborating with hiring managers, and enhancing candidate experiences while ensuring organized processes and timely communic...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$83K - $114K *

Champion safety and compliance by conducting thorough inspections of elevators and lifts, ensuring adherence to codes and standards while collaborating with service teams and property managers for opt...

6 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$180K - $200K *

Join us as a Principal Architect to drive technical innovation and unify systems across platforms. Collaborate with teams to design cloud-based solutions, mentor engineers, and enhance product deliver...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $100K *

Unlock potential by connecting communities with reliable telecommunication services. As a key player in outside sales, you'll engage directly with customers, driving growth and satisfaction through ta...

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Elevate enterprise AI initiatives by partnering with clients to drive strategic solutions. Leverage your expertise to engage senior leaders, design impactful demos, and accelerate deal cycles, ensurin...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$88K - $105K *

Drive the success of a 3D Environment production team by managing resources, monitoring performance, and ensuring quality delivery. Collaborate with stakeholders to optimize workflows and support empl...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$127K - $157K *

Champion medical affairs for Photofrin and PDT, engaging with healthcare professionals and leading initiatives. This role offers autonomy and visibility, ideal for experienced Medical Affairs professi...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock potential by building and deploying AI systems across diverse businesses. Collaborate with CEOs to identify needs, create prototypes, and drive growth through innovative solutions while managin...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$138K - $180K *

Lead the delivery of complex DevOps and cloud infrastructure projects, driving collaboration across engineering teams. Manage risks, dependencies, and execution plans to ensure successful project outc...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$222K - $288K *

Advance your career by leading global infrastructure strategy and operations. Drive modernization across cloud, networking, and security while ensuring compliance and scalability for 24/7 clinical and...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Healthcare

$90K - $180K *

Drive market expansion and adoption of innovative medical devices by developing strategic relationships and sales initiatives to increase market share within healthcare systems, focusing on cardiologi...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.