Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $96K *

Innovate with us to lead complex, multi-phase projects, ensuring timely delivery and quality standards. Collaborate with cross-functional teams and external partners to drive project success while man...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$146K - $293K *

Drive enterprise sales in Aerospace & Defense, creating strategic opportunities and engaging C-suite executives. Own the full sales cycle, leveraging Siemens' technology to deliver measurable business...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$91K - $121K *

Elevate the commercialization process across the product portfolio, enhancing efficiency and data integrity. Lead cross-functional collaboration, implement automation innovations, and drive strategic...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $95K *

Join a team that's shaping the future of AI in international development. Lead market research initiatives to identify opportunities, analyze trends, and provide strategic insights that drive business...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$207K - $244K *

Shape the financial data landscape by leading analytics initiatives, ensuring accurate, timely reporting and compliance. Collaborate with cross-functional teams to build scalable data pipelines and ma...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$171K - $236K *

Drive customer success by managing relationships, identifying upsell opportunities, and collaborating with teams to ensure long-term growth and satisfaction for existing clients, focusing on measurabl...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$135K - $200K *

Join us as a Senior Product Manager to shape the strategy and roadmap for a key product area, leveraging AI to drive innovation and enhance client value while collaborating with cross-functional teams...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's driving growth through strategic advisor practice acquisitions. Lead complex transactions from evaluation to closing, collaborating with key stakeholders to ensure alignment and del...

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Pioneer the delivery of impactful product features by guiding Agile teams, prioritizing stakeholder needs, and translating complex requirements into actionable user stories. Drive collaboration and co...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Drive financial strategy and execution for new business and client retention in the Higher Education Sector, optimizing revenue and profitability while collaborating with cross-functional teams to ens...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$151K - $201K *

Partner with us to drive profitable growth in E&S Casualty underwriting by managing complex accounts, building broker relationships, and executing strategic initiatives that enhance business performan...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$200K - $250K *

Champion security leadership by bridging complex challenges with business outcomes, driving revenue growth, and fostering trust with executive stakeholders in a customer-facing role focused on strateg...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$280K - $330K *

Lead the charge in enterprise sales by executing strategic plans to drive revenue growth and new customer acquisition. Collaborate with cross-functional teams to ensure customer satisfaction and achie...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Drive technology strategy by aligning investments with business goals, modernizing applications, and managing risk. Serve as a trusted advisor to leadership, establishing roadmaps and governance for a...

6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $188K *

Drive the development of innovative cloud-native applications and AI features as a full-stack developer. Collaborate with senior engineers to enhance your skills while delivering impactful solutions i...

6 days ago

  •   Less than 5 years exp.  •   Business Services

$95K - $188K *

Unlock your potential as a full-stack developer, contributing to cloud-native applications and AI features. Collaborate with senior engineers, enhance your skills, and deliver impactful software solut...

6 days ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Empower healthcare delivery by integrating clinical science with technology. Collaborate with teams to enhance workflows, resolve issues, and support the adoption of electronic health records for impr...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$166K - $200K *

Unlock potential by leading operations across multiple plants in the Missouri Area. Drive sales, production, and customer service while fostering a culture of engagement and safety. Collaborate with t...

Missouri, USRemote

6 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$90K - $110K *

Lead the charge in driving revenue growth by managing the full sales cycle for innovative event marketing solutions. Utilize your entrepreneurial spirit and consultative approach to transform client o...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$90K - $110K *

Champion client success by managing enterprise accounts, driving growth, and enhancing internal processes. Collaborate with cross-functional teams to deliver exceptional service and support, ensuring...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Join a team that's dedicated to maximizing client success through effective software implementations. Collaborate with customers and partners to ensure timely project delivery while continuously impro...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $128K *

Drive impactful internal communications strategies that engage employees, enhance collaboration, and support organizational growth. Partner with diverse teams to optimize messaging and foster a strong...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Unlock potential by leading sales strategy and team development to drive revenue growth. This senior role requires strategic vision and strong leadership to enhance market presence and foster talent w...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$79K - $107K *

Drive innovative structural designs for solar infrastructure projects, collaborating with multi-disciplinary teams to ensure compliance with building codes and project specifications while providing e...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $130K *

Transform your career by designing and delivering complex full-stack solutions using Java, Spring Boot, and Angular. Collaborate with teams to enhance engineering quality and lead technical initiative...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.