Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $120K *

Lead the charge in quality engineering for critical assessment platforms, driving testing excellence and automation maturity. Collaborate with cross-functional teams to ensure reliability and scalabil...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$108K - $130K *

Elevate strategic analytics by leading a high-performing team to deliver impactful insights, drive business growth, and foster cross-functional collaboration through advanced data modeling and executi...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $120K *

Join a team that's dedicated to delivering exceptional primary eye care while fostering a positive, patient-first culture. Enjoy the freedom to practice your way and grow your expertise in a supportiv...

6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Engineer transformative HR strategies as a trusted advisor, partnering with executives to tackle complex workforce challenges and align people initiatives with business goals in a fast-paced environme...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$107K - $139K *

Help us lead complex quality improvement projects across multiple sites, integrating quality management systems and enhancing manufacturing processes. Collaborate with cross-functional teams to ensure...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Healthcare

$72K - $116K *

Join us in leading our team to achieve excellence in pet care, drive operational success, and enhance customer experiences while fostering a positive culture and community growth in a dynamic retail e...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Join a team that's dedicated to empowering franchise partners through expert consulting and support. You'll build trusted relationships, drive operational excellence, and help franchisees achieve thei...

6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$90K - $100K *

Drive new business opportunities and exceed sales targets by building strong customer relationships and executing tailored sales strategies in a dynamic market environment...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$146K - $269K *

Empower innovation by leading vendor AI integration standards, ensuring compliance and interoperability across the enterprise. Drive assessments, manage relationships, and oversee ongoing adherence to...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $100K *

Join a team that's driving financial insights and pricing strategies to enhance profitability. Collaborate with cross-functional teams to support client proposals and contract renewals while navigatin...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Transform the future of engineering by leading innovative mechanical designs for mission-critical facilities. Drive projects from concept to completion, ensuring reliability and efficiency in HVAC and...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$212K - $222K *

Champion client success as you lead Aera solution deployments, building trusted relationships with executives to drive value and Decision Intelligence roadmaps while managing project delivery and fost...

United StatesRemote

Reposted 6 days ago

  •   11 - 15 years exp.  •   Information Technology

$84K - $136K *

Transform workplace safety by leading initiatives, training, and compliance efforts. Drive a culture of safety, ensuring adherence to regulations while empowering employees to prioritize health and se...

6 days ago

  •   Less than 5 years exp.  •   Food & Beverages

$104K - $140K *

Help us drive innovation as a Principal Electrical Engineer, specializing in power systems. You will lead design teams, engage with customers, and develop cutting-edge power electronics to meet requir...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$96K - $144K *

Champion process automation and digital manufacturing as a Senior Process Control Engineer, driving efficiency and reliability while enhancing organizational capabilities and ensuring sustainable oper...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $170K *

Elevate employee experiences by leading the design and implementation of integrated HR Service Delivery solutions leveraging ServiceNow and Microsoft technologies...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$250K - $250K+*

Pioneer the future of developer AI by architecting scalable backend systems that enhance real-world product experiences through developer-centric cloud infrastructure...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Engage in advanced security operations as a Senior Security Analyst, leading incident response, enhancing detection capabilities, and driving process improvements to protect critical assets in a dynam...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$137K - $188K *

Drive innovation in data engineering by leading a dedicated team to develop robust data pipelines, ensuring high-quality data products that empower business decisions and enhance our digital capabilit...

6 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$88K - $105K *

Join a team that's dedicated to driving engineering excellence and innovation. Oversee a skilled group of engineers, manage budgets, and ensure timely project completion while fostering collaboration...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$95K - $115K *

Transform data governance by leveraging your technical expertise in Collibra and data quality tools. Drive accuracy and reliability of data assets through hands-on implementation and analysis, ensurin...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$115K - $138K *

Transform project delivery by leading complex, multi-phase initiatives. Oversee cross-functional teams, manage budgets, and ensure timely completion while aligning outcomes with client expectations an...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$83K *

Transform the lives of youth and families by providing comprehensive clinical assessments, therapy, and case management in a dynamic inpatient and residential treatment environment. Collaborate with a...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$185K - $344K *

Lead a dynamic team in developing cutting-edge machine learning infrastructure, driving AI initiatives that impact millions. Foster collaboration and continuous improvement while mentoring talent in a...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$130K - $155K *

Unlock potential by driving innovative AI solutions through hands-on engineering and client collaboration. Transform complex business challenges into reliable, production-ready software while enhancin...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.