Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Director, Health Economics & Reimbursement (HE&R), Field - Cardiac Rhythm Management (US-Remote)
$149K - $298K *
Unlock potential by leading the U.S. CRM Field Health Economics & Reimbursement team to enhance patient access and drive therapy adoption through strategic reimbursement initiatives and stakeholder co...
6 days ago
Claims Team Manager - Casualty
$92K - $123K *
Elevate your career by leading a dynamic claims team, ensuring compliance and excellence in customer service. Drive performance through coaching, strategic oversight, and effective communication while...
6 days ago
$98K - $144K *
Pioneer innovative commercial lending solutions by developing strategies that enhance growth, profitability, and customer experience. Collaborate with cross-functional teams to optimize product perfor...
6 days ago
$125K - $150K *
Lead the charge in comprehensive pharmacy oversight, ensuring optimal patient care and operational efficiency. Collaborate with healthcare teams to enhance pharmacy services and mentor staff while man...
6 days ago
Strategic Clients Manager, Geisinger Health Plan (Pennsylvania resident)
$88K - $105K *
Grow your career with a pivotal role in client relationship management, enhancing membership retention and expanding strategic partnerships through exceptional service and sales expertise in a dynamic...
6 days ago
Senior Manager, Trust Services & Operations
$83K - $141K *
Oversee trust and wealth operations, ensuring compliance and efficiency in fiduciary services. Lead a team to enhance service delivery, manage performance metrics, and implement operational improvemen...
6 days ago
$107K - $182K *
Contribute to the financial well-being of ultra-high net worth clients by developing comprehensive financial plans, delivering tailored recommendations, and ensuring exceptional service through collab...
6 days ago
Infrastructure Optimization & AI Technical Lead
$96K - $181K *
Lead the transformation of enterprise technology by architecting scalable GCP solutions and guiding cross-functional teams in developing robust AI-driven applications. Drive innovation through hands-o...
6 days ago
$69K - $115K *
Champion data-driven insights by collaborating with teams to standardize datasets, develop self-service dashboards, and translate business needs into actionable data requirements, enhancing transparen...
6 days ago
Large Loss Property Field Claims Adjuster (Oregon)
$88K - $145K *
Join a dynamic team to investigate and manage complex property claims, ensuring thorough evaluations and customer satisfaction while working independently in the field. Leverage your expertise to ment...
6 days ago
Chief Operations Officer - Industrial Solutions
$210K - $250K *
Lead global operations for a diverse specialty materials portfolio, driving excellence in safety, quality, and supply chain. Foster innovation and optimize production to ensure timely delivery and cos...
6 days ago
$80K - $95K *
Unlock your potential by leading a dynamic sales team to drive growth and profitability. Foster relationships, implement strategies, and achieve sales targets while ensuring alignment with company val...
6 days ago
$83K - $107K *
Empower the future of organ transplantation by screening donor offers, coordinating clinical evaluations, and collaborating with diverse teams to enhance organ utilization and patient outcomes in a dy...
6 days ago
$83K - $107K *
Transform donor assessment processes by screening organ offers, coordinating with transplant teams, and ensuring compliance with OPTN policies to enhance organ utilization and patient outcomes...
6 days ago
Associate Director, Field Medical Affairs, Cutaneous Oncology (IN, KY, MI, OH and WV)
$176K - $287K *
Develop and maintain strategic relationships with key opinion leaders while serving as a clinical resource for healthcare professionals. Drive evidence generation and support educational initiatives i...
6 days ago
$153K - $207K *
Lead impactful initiatives in healthcare fraud analysis, driving data-driven solutions and collaborating with cross-functional teams to enhance Medicaid and Medicare outcomes while presenting findings...
6 days ago
Detection Engineer, Falcon Complete (Remote)
$100K - $150K *
Join a team that's redefining threat detection by developing high-fidelity SIEM rules and leveraging AI tools. Collaborate across the detection pipeline to enhance response capabilities and drive inno...
6 days ago
Detection Engineer, Falcon Complete (Remote)
$100K - $150K *
Drive high-fidelity detection development by leveraging threat intelligence and AI tools. Collaborate across the detection pipeline to enhance triage efficiency and accelerate threat disruption in a d...
6 days ago
Manager Population Health Care Management - Registered Nurse
$80K - $95K *
Manage and enhance care management operations, ensuring effective implementation of evidence-based practices while fostering team collaboration and patient satisfaction across diverse healthcare setti...
6 days ago
$87K - $92K *
Drive impactful flatbed operations by ensuring efficient load securement and timely deliveries. Leverage your experience to maintain high standards of safety and productivity while enjoying regular ho...
6 days ago
Nurse Practitioner or Physician Assistant - Critical Care, Mercy Hospital St. Louis
$100K - $120K *
Engage with our Critical Care team to enhance patient outcomes through expert care, rounding in the ICU, performing procedures, and responding to rapid calls. Collaborate with physicians and support s...
Reposted 6 days ago
$80K - $88K *
Empower your creativity as you design impactful brand assets across various channels, ensuring visual consistency and engaging storytelling. Collaborate with marketing to elevate brand identity and dr...
Reposted 6 days ago
National Accounts Lead Director, Clinical Program Consultant (CPC)
$100K - $231K *
Transform healthcare outcomes by leading a team of Clinical Program Consultants to analyze data, optimize clinical programs, and drive strategic initiatives that enhance customer health and reduce cos...
Reposted 6 days ago
Medical Director, Medical Affairs
$174K - $374K *
Lead the charge in clinical oversight and mentorship, providing strategic support across various departments. Collaborate with teams to ensure evidence-based decision-making and enhance patient care t...
6 days ago
$80K - $95K *
Engage with a dynamic team to deliver on-site training for HCUS Modality products, ensuring optimal image quality and customer satisfaction through effective communication and support across various d...
6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.